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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HIVEP2

Summary for HIVEP2

Gene information	Gene symbol	HIVEP2
	Ensembl ID	ENSG00000010818
	Entrez ID	3097
	Gene name	HIVEP zinc finger 2
	Synonyms	HIV-EP2\|MBP-2\|MIBP1\|Schnurri-2\|ZAS2\|ZNF40B
	Gene type	protein_coding
	UniProtAcc	P31629

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Dataset with differentially expressed gene: HIVEP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.281682	1.31e-15

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Expression of HIVEP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HIVEP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HIVEP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HIVEP2	hsa-miR-493-5p	99.054	NM_006734
HIVEP2	hsa-miR-5011-5p	97.8083	NM_006734
HIVEP2	hsa-let-7c-3p	97.2309	NM_006734
HIVEP2	hsa-miR-3613-3p	96.4251	NM_006734
HIVEP2	hsa-miR-4753-3p	96.1159	NM_006734
HIVEP2	hsa-miR-383-3p	95.7585	NM_006734
HIVEP2	hsa-miR-3973	95.6301	NM_006734
HIVEP2	hsa-miR-585-5p	95.0932	NM_006734
HIVEP2	hsa-miR-381-3p	95.03	NM_006734
HIVEP2	hsa-miR-300	95.03	NM_006734
HIVEP2	hsa-miR-548l	94.2023	NM_006734
HIVEP2	hsa-miR-130a-5p	93.6123	NM_006734
HIVEP2	hsa-miR-3658	93.5035	NM_006734
HIVEP2	hsa-miR-548n	93.3742	NM_006734
HIVEP2	hsa-miR-155-5p	93.3441	NM_006734
HIVEP2	hsa-miR-4718	93.2841	NM_006734
HIVEP2	hsa-miR-6809-3p	92.4516	NM_006734
HIVEP2	hsa-miR-5684	92.2726	NM_006734
HIVEP2	hsa-miR-4491	92.0042	NM_006734
HIVEP2	hsa-miR-4657	92.0042	NM_006734
HIVEP2	hsa-miR-6833-5p	91.0514	NM_006734
HIVEP2	hsa-miR-124-3p	90.9658	NM_006734
HIVEP2	hsa-miR-506-3p	90.9658	NM_006734
HIVEP2	hsa-miR-4511	90.5977	NM_006734
HIVEP2	hsa-miR-29b-2-5p	90.1973	NM_006734
HIVEP2	hsa-miR-4307	89.7842	NM_006734
HIVEP2	hsa-miR-3133	89.7283	NM_006734
HIVEP2	hsa-miR-607	89.6759	NM_006734
HIVEP2	hsa-miR-5093	89.153	NM_006734
HIVEP2	hsa-miR-10527-5p	87.996	NM_006734
HIVEP2	hsa-miR-496	87.783	NM_006734
HIVEP2	hsa-miR-524-5p	87.7429	NM_006734
HIVEP2	hsa-miR-520d-5p	87.7429	NM_006734
HIVEP2	hsa-miR-6504-3p	87.2942	NM_006734
HIVEP2	hsa-miR-10399-5p	87.2942	NM_006734
HIVEP2	hsa-miR-3977	86.993	NM_006734
HIVEP2	hsa-miR-4775	86.4498	NM_006734
HIVEP2	hsa-miR-484	86.4109	NM_006734
HIVEP2	hsa-miR-3163	85.9067	NM_006734
HIVEP2	hsa-miR-454-3p	85.5654	NM_006734
HIVEP2	hsa-miR-4666a-3p	85.3964	NM_006734
HIVEP2	hsa-miR-5688	85.2456	NM_006734
HIVEP2	hsa-miR-5586-5p	85.2325	NM_006734
HIVEP2	hsa-miR-6508-5p	84.3213	NM_006734
HIVEP2	hsa-miR-3155a	84.2041	NM_006734
HIVEP2	hsa-miR-3155b	84.2041	NM_006734
HIVEP2	hsa-miR-5582-5p	83.9619	NM_006734
HIVEP2	hsa-miR-301a-3p	83.4681	NM_006734
HIVEP2	hsa-miR-301b-3p	83.4681	NM_006734
HIVEP2	hsa-miR-3666	83.4681	NM_006734

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Motifs and transcription factors (TFs) regulating HIVEP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HIVEP2	metacluster_135.11	NR2C2 (directAnnotation).
HIVEP2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
HIVEP2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
HIVEP2	metacluster_7.13	ZFX (directAnnotation).
HIVEP2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
HIVEP2	cisbp__M00968	MTF2 (directAnnotation).
HIVEP2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
HIVEP2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
HIVEP2	cisbp__M00341	PAX6 (directAnnotation).
HIVEP2	metacluster_198.3	ZFP64 (directAnnotation).
HIVEP2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
HIVEP2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
HIVEP2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
HIVEP2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
HIVEP2	cisbp__M00788	ZFY (inferredBy_Orthology).
HIVEP2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
HIVEP2	metacluster_175.1	ZNF283 (directAnnotation).
HIVEP2	hdpi__ZNF304	ZNF304 (directAnnotation).
HIVEP2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
HIVEP2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
HIVEP2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
HIVEP2	transfac_pro__M01199	TRIM28 (directAnnotation).
HIVEP2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
HIVEP2	metacluster_151.2	ZNF23 (directAnnotation).
HIVEP2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
HIVEP2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
HIVEP2	transfac_pro__M03806	ZBTB7C (directAnnotation).
HIVEP2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."