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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HGF

Summary for HGF

Gene information	Gene symbol	HGF
	Ensembl ID	ENSG00000019991
	Entrez ID	3082
	Gene name	hepatocyte growth factor
	Synonyms	DFNB39\|F-TCF\|HGFB\|HPTA\|SF
	Gene type	protein_coding
	UniProtAcc	P14210

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Dataset with differentially expressed gene: HGF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.54256	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.375811	3.30e-15
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.753338	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.930635	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.790707	0.00e+00

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Expression of HGF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HGF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HGF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HGF	hsa-miR-4714-3p	96.53	NM_001010934
HGF	hsa-miR-4768-3p	95.2294	NM_000601
HGF	hsa-miR-4716-3p	94.458	NM_001010934
HGF	hsa-miR-6794-5p	94.458	NM_001010934
HGF	hsa-miR-95-5p	93.0692	NM_000601
HGF	hsa-miR-3163	92.6199	NM_000601
HGF	hsa-miR-7159-5p	92.2031	NM_000601
HGF	hsa-miR-3662	91.8959	NM_001010932
HGF	hsa-miR-26b-5p	91.842	NM_000601
HGF	hsa-miR-1297	91.842	NM_000601
HGF	hsa-miR-26a-5p	91.842	NM_000601
HGF	hsa-miR-6760-3p	91.5832	NM_000601
HGF	hsa-miR-655-5p	91.4932	NM_000601
HGF	hsa-miR-3924	91.4017	NM_001010932
HGF	hsa-miR-324-3p	91.3066	NM_001010934
HGF	hsa-miR-3613-3p	91.1801	NM_001010932
HGF	hsa-miR-520e-5p	90.442	NM_000601
HGF	hsa-miR-1288-3p	90.353	NM_001010933
HGF	hsa-miR-513a-5p	90.0316	NM_001010932
HGF	hsa-miR-4328	90.0011	NM_001010934
HGF	hsa-miR-4282	89.91	NM_001010932
HGF	hsa-miR-676-5p	89.6744	NM_001010932
HGF	hsa-miR-135a-3p	89.2485	NM_001010934
HGF	hsa-miR-543	88.6967	NM_000601
HGF	hsa-miR-4465	88.1755	NM_000601
HGF	hsa-miR-766-5p	87.5528	NM_001010934
HGF	hsa-miR-570-3p	86.8359	NM_001010934
HGF	hsa-miR-204-5p	86.2325	NM_001010932
HGF	hsa-miR-211-5p	86.2325	NM_001010932
HGF	hsa-miR-5189-3p	86.0706	NM_001010932
HGF	hsa-miR-374a-5p	86.0647	NM_001010932
HGF	hsa-miR-376b-3p	85.8291	NM_001010934
HGF	hsa-miR-376a-3p	85.8291	NM_001010934
HGF	hsa-miR-4710	85.5004	NM_001010932
HGF	hsa-miR-568	85.1258	NM_001010934
HGF	hsa-miR-6832-3p	84.6007	NM_001010932
HGF	hsa-miR-3646	84.0413	NM_001010932
HGF	hsa-miR-3925-3p	84.0101	NM_000601
HGF	hsa-miR-487b-5p	83.4323	NM_001010932
HGF	hsa-miR-487a-5p	83.4323	NM_001010932
HGF	hsa-miR-6882-5p	83.3324	NM_001010932
HGF	hsa-miR-4802-5p	83.1028	NM_001010934
HGF	hsa-miR-1843	83.1028	NM_001010934
HGF	hsa-miR-425-5p	82.9637	NM_001010932
HGF	hsa-miR-5688	82.8442	NM_001010934
HGF	hsa-miR-141-3p	82.5981	NM_001010932
HGF	hsa-miR-200a-3p	82.5981	NM_001010932
HGF	hsa-miR-544a	82.0871	NM_000601
HGF	hsa-miR-374b-5p	81.789	NM_001010932
HGF	hsa-miR-10523-5p	81.7341	NM_001010934

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Motifs and transcription factors (TFs) regulating HGF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HGF	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
HGF	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
HGF	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
HGF	metacluster_141.4	GLIS2 (directAnnotation).
HGF	taipale_cyt_meth__ELF3_NTGTGCGGATGCN_FL_repr	ELF3 (directAnnotation).
HGF	jaspar__MA1483.2	ELF2 (directAnnotation).
HGF	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
HGF	jaspar__MA1708.1	ETV7 (directAnnotation).
HGF	swissregulon__hs__ETV6	ETV6 (directAnnotation).
HGF	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
HGF	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
HGF	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
HGF	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
HGF	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNNTTRCGYAAN_CAP	CEBPB; GCM1 (directAnnotation).
HGF	hocomoco__HSFY1_HUMAN.H11MO.0.D	HSFY1; HSFY2 (directAnnotation).
HGF	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
HGF	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
HGF	jaspar__MA1957.1	ELK1 (directAnnotation).
HGF	transfac_pro__M06085	ZNF26 (directAnnotation).
HGF	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
HGF	tfdimers__MD00138	IRF1; IRF2; IRF3; IRF4; IRF5; IRF7; IRF8; IRF9; MYB (directAnnotation).
HGF	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
HGF	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
HGF	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
HGF	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
HGF	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
HGF	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
HGF	cisbp__M08198	ELF1 (directAnnotation).
HGF	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
HGF	transfac_pro__M06237	ZNF846 (directAnnotation).
HGF	kznf__ZNF33A_Schmitges2016_RCADE	ZNF33A (directAnnotation).
HGF	transfac_pro__M06766	ZNF835 (directAnnotation).
HGF	tfdimers__MD00269	CRX; PBX1 (directAnnotation).
HGF	metacluster_29.4	BCL6; BCL6; BCL6; BCL6; BCL6B; BCL6B; BCL6B; BCL6B; BCL6B (directAnnotation). BCL6; BCL6; BCL6 (inferredBy_Orthology).
HGF	transfac_pro__M01425	HNF1B (directAnnotation).
HGF	transfac_pro__M06280	ZFP69 (directAnnotation).
HGF	transfac_pro__M06226	ZNF460 (directAnnotation).
HGF	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
HGF	transfac_pro__M01969	FOXO1 (directAnnotation).
HGF	swissregulon__hs__CLOCK	CLOCK (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HGF	"ABT-510"	DB05434	small molecule
HGF	"Foretinib"	DB12307	small molecule
HGF	"Heparin"	DB01109	small molecule
HGF	"N,O6-Disulfo-Glucosamine"	DB03959	small molecule
HGF	"O2-Sulfo-Glucuronic Acid"	DB02264	small molecule
HGF	"Valproic acid"	DB00313	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."