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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target

Gene: HDAC2

Summary for HDAC2

Gene information	Gene symbol	HDAC2
	Ensembl ID	ENSG00000196591
	Entrez ID	3066
	Gene name	histone deacetylase 2
	Synonyms	KDAC2\|RPD3\|YAF1
	Gene type	protein_coding
	UniProtAcc	Q92769

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Dataset with differentially expressed gene: HDAC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.884649	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.44833	2.29e-29
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.912194	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.425424	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.264358	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.51777	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.257057	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.661136	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.622237	3.58e-27
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.67807	1.42e-42
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.538659	1.16e-19
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.924145	0.00e+00

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Expression of HDAC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HDAC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HDAC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HDAC2	hsa-miR-6872-3p	97.0458	NM_001527
HDAC2	hsa-miR-3646	96.3812	NM_001527
HDAC2	hsa-miR-6750-3p	96.1967	NM_001527
HDAC2	hsa-miR-3165	96.1751	NM_001527
HDAC2	hsa-miR-6880-5p	95.7429	NM_001527
HDAC2	hsa-miR-3148	94.6449	NM_001527
HDAC2	hsa-miR-3613-3p	94.4223	NM_001527
HDAC2	hsa-miR-7-2-3p	94.3701	NM_001527
HDAC2	hsa-miR-7-1-3p	94.3701	NM_001527
HDAC2	hsa-miR-8071	93.924	NM_001527
HDAC2	hsa-miR-527	93.8384	NM_001527
HDAC2	hsa-miR-518a-5p	93.8384	NM_001527
HDAC2	hsa-miR-3977	93.6935	NM_001527
HDAC2	hsa-miR-3682-5p	92.3502	NM_001527
HDAC2	hsa-miR-3168	92.0769	NM_001527
HDAC2	hsa-miR-524-5p	90.8962	NM_001527
HDAC2	hsa-miR-520d-5p	90.8962	NM_001527
HDAC2	hsa-miR-4786-3p	90.8719	NM_001527
HDAC2	hsa-miR-7843-3p	90.8346	NM_001527
HDAC2	hsa-miR-3163	90.1385	NM_001527
HDAC2	hsa-miR-3662	89.875	NM_001527
HDAC2	hsa-miR-4426	89.8183	NM_001527
HDAC2	hsa-miR-4328	87.7818	NM_001527
HDAC2	hsa-miR-4422	87.6734	NM_001527
HDAC2	hsa-miR-373-5p	87.1417	NM_001527
HDAC2	hsa-miR-371b-5p	87.1417	NM_001527
HDAC2	hsa-miR-616-5p	87.1417	NM_001527
HDAC2	hsa-miR-3658	86.84	NM_001527
HDAC2	hsa-miR-10397-3p	86.4954	NM_001527
HDAC2	hsa-miR-7855-5p	86.2305	NM_001527
HDAC2	hsa-miR-4274	85.7421	NM_001527
HDAC2	hsa-miR-34a-3p	85.1738	NM_001527
HDAC2	hsa-miR-4647	84.1563	NM_001527
HDAC2	hsa-miR-4662b	84.1563	NM_001527
HDAC2	hsa-miR-6785-5p	84.0173	NM_001527
HDAC2	hsa-miR-4728-5p	84.0173	NM_001527
HDAC2	hsa-miR-6817-5p	83.8441	NM_001527
HDAC2	hsa-miR-4769-3p	83.8441	NM_001527
HDAC2	hsa-miR-3661	83.715	NM_001527
HDAC2	hsa-miR-362-5p	83.041	NM_001527
HDAC2	hsa-miR-500b-5p	83.041	NM_001527
HDAC2	hsa-miR-519d-5p	82.591	NM_001527
HDAC2	hsa-miR-526b-5p	82.2989	NM_001527
HDAC2	hsa-miR-4742-3p	81.8668	NM_001527
HDAC2	hsa-miR-631	81.4012	NM_001527
HDAC2	hsa-miR-153-5p	80.867	NM_001527
HDAC2	hsa-miR-377-3p	80.8177	NM_001527
HDAC2	hsa-miR-5582-3p	80.4783	NM_001527
HDAC2	hsa-miR-6768-3p	80.2636	NM_001527
HDAC2	hsa-miR-548c-3p	80.1234	NM_001527

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Motifs and transcription factors (TFs) regulating HDAC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HDAC2	transfac_pro__M06035	ZNF749 (directAnnotation).
HDAC2	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
HDAC2	jaspar__MA1596.1	ZNF460 (directAnnotation).
HDAC2	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
HDAC2	metacluster_98.1	ZNF524 (directAnnotation).
HDAC2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
HDAC2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
HDAC2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
HDAC2	hdpi__TP73	TP73 (directAnnotation).
HDAC2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
HDAC2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
HDAC2	transfac_public__M00024	E2F1 (directAnnotation).
HDAC2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
HDAC2	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
HDAC2	transfac_pro__M04826	EP300 (directAnnotation).
HDAC2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
HDAC2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
HDAC2	transfac_pro__M04950	EGR1 (directAnnotation).
HDAC2	hdpi__FLI1	FLI1 (directAnnotation).
HDAC2	transfac_pro__M00652	NRF1 (directAnnotation).
HDAC2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
HDAC2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
HDAC2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
HDAC2	transfac_pro__M05817	ZNF546 (directAnnotation).
HDAC2	hdpi__ETV4	ETV4 (directAnnotation).
HDAC2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
HDAC2	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
HDAC2	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
HDAC2	transfac_pro__M00492	STAT1 (directAnnotation).
HDAC2	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
HDAC2	transfac_pro__M01298	MECP2 (directAnnotation).
HDAC2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
HDAC2	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
HDAC2	transfac_pro__M04918	EGR1 (directAnnotation).
HDAC2	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
HDAC2	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
HDAC2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
HDAC2	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
HDAC2	jaspar__MA0748.2	YY2 (directAnnotation).
HDAC2	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
HDAC2	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
HDAC2	metacluster_182.10	ZFX (directAnnotation).
HDAC2	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
HDAC2	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
HDAC2	transfac_pro__M02913	SP140 (inferredBy_Orthology).
HDAC2	transfac_pro__M07483	CXXC1 (directAnnotation).
HDAC2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
HDAC2	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
HDAC2	cisbp__M08198	ELF1 (directAnnotation).
HDAC2	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
HDAC2	transfac_pro__M04866	up	Malignant cells	GSE139386	NA
HDAC2	transfac_pro__M04870	down	Malignant cells	GSE199333	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HDAC2	"Aminophylline"	DB01223	small molecule
HDAC2	"Atorvastatin"	DB01076	small molecule
HDAC2	"Fluvastatin"	DB01095	small molecule
HDAC2	"Lovastatin"	DB00227	small molecule
HDAC2	"Mocetinostat"	DB11830	small molecule
HDAC2	"Oxtriphylline"	DB01303	small molecule
HDAC2	"Pracinostat"	DB05223	small molecule
HDAC2	"Pravastatin"	DB00175	small molecule
HDAC2	"Romidepsin"	DB06176	small molecule
HDAC2	"Simvastatin"	DB00641	small molecule
HDAC2	"Theophylline"	DB00277	small molecule
HDAC2	"Tixocortol"	DB09091	small molecule
HDAC2	"Valproic acid"	DB00313	small molecule
HDAC2	"Vorinostat"	DB02546	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."