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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPATCH8

Summary for GPATCH8

Gene information	Gene symbol	GPATCH8
	Ensembl ID	ENSG00000186566
	Entrez ID	23131
	Gene name	G-patch domain containing 8
	Synonyms	GPATC8\|KIAA0553
	Gene type	protein_coding
	UniProtAcc	Q9UKJ3

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Dataset with differentially expressed gene: GPATCH8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.293142	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.250538	1.65e-28
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.253049	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.298059	3.71e-32
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.392736	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.332506	3.75e-32

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Expression of GPATCH8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPATCH8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPATCH8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPATCH8	hsa-miR-619-5p	98.0936	NM_001304941
GPATCH8	hsa-miR-6506-5p	98.0936	NM_001304941
GPATCH8	hsa-miR-2467-3p	97.538	NM_001304941
GPATCH8	hsa-miR-605-3p	97.0596	NM_001002909
GPATCH8	hsa-miR-6876-5p	96.3263	NM_001002909
GPATCH8	hsa-miR-424-5p	95.7706	NM_001002909
GPATCH8	hsa-miR-4314	95.1866	NM_001304941
GPATCH8	hsa-miR-6733-3p	95.1616	NM_001304941
GPATCH8	hsa-miR-4476	94.8538	NM_001002909
GPATCH8	hsa-miR-16-5p	94.6976	NM_001002909
GPATCH8	hsa-miR-15b-5p	94.6976	NM_001002909
GPATCH8	hsa-miR-195-5p	94.6976	NM_001002909
GPATCH8	hsa-miR-15a-5p	94.6976	NM_001002909
GPATCH8	hsa-miR-497-5p	94.6976	NM_001002909
GPATCH8	hsa-miR-6838-5p	94.6976	NM_001002909
GPATCH8	hsa-miR-34b-3p	94.5258	NM_001002909
GPATCH8	hsa-miR-670-5p	94.4668	NM_001002909
GPATCH8	hsa-miR-6130	93.9461	NM_001002909
GPATCH8	hsa-miR-124-3p	93.8183	NM_001002909
GPATCH8	hsa-miR-506-3p	93.8183	NM_001002909
GPATCH8	hsa-miR-6133	92.4004	NM_001002909
GPATCH8	hsa-miR-4510	92.4004	NM_001002909
GPATCH8	hsa-miR-6127	92.4004	NM_001002909
GPATCH8	hsa-miR-6129	92.4004	NM_001002909
GPATCH8	hsa-miR-10527-5p	92.2825	NM_001002909
GPATCH8	hsa-miR-3613-3p	92.0967	NM_001002909
GPATCH8	hsa-miR-1283	92.0135	NM_001002909
GPATCH8	hsa-miR-3120-3p	91.9011	NM_001002909
GPATCH8	hsa-miR-34c-3p	91.4074	NM_001002909
GPATCH8	hsa-miR-4487	91.3804	NM_001304941
GPATCH8	hsa-miR-556-5p	91.2998	NM_001304941
GPATCH8	hsa-miR-4668-3p	91.2799	NM_001002909
GPATCH8	hsa-miR-5582-5p	90.9146	NM_001002909
GPATCH8	hsa-miR-545-3p	90.3099	NM_001002909
GPATCH8	hsa-miR-153-5p	89.567	NM_001304941
GPATCH8	hsa-miR-148a-3p	89.2375	NM_001002909
GPATCH8	hsa-miR-148b-3p	89.2375	NM_001002909
GPATCH8	hsa-miR-152-3p	89.2375	NM_001002909
GPATCH8	hsa-miR-4319	88.4585	NM_001002909
GPATCH8	hsa-miR-337-3p	88.3408	NM_001304941
GPATCH8	hsa-miR-3689a-5p	87.68	NM_001304941
GPATCH8	hsa-miR-3689f	87.68	NM_001304941
GPATCH8	hsa-miR-3689b-5p	87.68	NM_001304941
GPATCH8	hsa-miR-3689e	87.68	NM_001304941
GPATCH8	hsa-miR-133a-5p	87.4994	NM_001304941
GPATCH8	hsa-miR-1299	87.3742	NM_001304941
GPATCH8	hsa-miR-299-5p	86.9948	NM_001002909
GPATCH8	hsa-miR-1287-3p	85.5579	NM_001304941
GPATCH8	hsa-miR-125a-5p	85.3045	NM_001002909
GPATCH8	hsa-miR-125b-5p	85.3045	NM_001002909

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Motifs and transcription factors (TFs) regulating GPATCH8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPATCH8	cisbp__M01863	ZNF711 (inferredBy_Orthology).
GPATCH8	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
GPATCH8	jaspar__MA1483.2	ELF2 (directAnnotation).
GPATCH8	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GPATCH8	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
GPATCH8	metacluster_182.10	ZFX (directAnnotation).
GPATCH8	hdpi__ETV4	ETV4 (directAnnotation).
GPATCH8	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
GPATCH8	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
GPATCH8	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
GPATCH8	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
GPATCH8	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
GPATCH8	transfac_pro__M02090	E2F4 (directAnnotation).
GPATCH8	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
GPATCH8	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
GPATCH8	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
GPATCH8	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
GPATCH8	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
GPATCH8	metacluster_135.11	NR2C2 (directAnnotation).
GPATCH8	metacluster_160.20	JUND; PRDM15 (directAnnotation).
GPATCH8	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
GPATCH8	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
GPATCH8	cisbp__M00788	ZFY (inferredBy_Orthology).
GPATCH8	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
GPATCH8	metacluster_175.1	ZNF283 (directAnnotation).
GPATCH8	hdpi__ZNF304	ZNF304 (directAnnotation).
GPATCH8	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
GPATCH8	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
GPATCH8	transfac_pro__M02913	SP140 (inferredBy_Orthology).
GPATCH8	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
GPATCH8	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
GPATCH8	transfac_pro__M00430	E2F1 (directAnnotation).
GPATCH8	transfac_pro__M04893	TAF1 (directAnnotation).
GPATCH8	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
GPATCH8	hdpi__TP73	TP73 (directAnnotation).
GPATCH8	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
GPATCH8	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
GPATCH8	hdpi__HIP2	UBE2K (directAnnotation).
GPATCH8	hdpi__TIMELESS	TIMELESS (directAnnotation).
GPATCH8	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
GPATCH8	metacluster_191.5	SPDEF (inferredBy_Orthology).
GPATCH8	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
GPATCH8	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
GPATCH8	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
GPATCH8	hdpi__RARA	RARA (directAnnotation).
GPATCH8	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
GPATCH8	hdpi__ELF2	ELF2 (directAnnotation).
GPATCH8	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
GPATCH8	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
GPATCH8	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."