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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPATCH2

Summary for GPATCH2

Gene information	Gene symbol	GPATCH2
	Ensembl ID	ENSG00000092978
	Entrez ID	55105
	Gene name	G-patch domain containing 2
	Synonyms	CT110\|FLJ10252\|GPATC2\|Pfa1\|PPP1R30
	Gene type	protein_coding
	UniProtAcc	Q9NW75

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Dataset with differentially expressed gene: GPATCH2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.289061	1.35e-18
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.260661	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.273492	2.91e-19

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Expression of GPATCH2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPATCH2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPATCH2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPATCH2	hsa-miR-4282	98.7652	NM_018040
GPATCH2	hsa-miR-3163	98.0438	NM_018040
GPATCH2	hsa-miR-1304-5p	95.6284	NM_018040
GPATCH2	hsa-miR-16-2-3p	94.7787	NM_018040
GPATCH2	hsa-miR-195-3p	94.7787	NM_018040
GPATCH2	hsa-miR-887-5p	94.507	NM_018040
GPATCH2	hsa-miR-5682	94.3499	NM_018040
GPATCH2	hsa-miR-6757-5p	94.1422	NM_018040
GPATCH2	hsa-miR-20a-3p	94.0835	NM_018040
GPATCH2	hsa-miR-30c-1-3p	93.7747	NM_018040
GPATCH2	hsa-miR-30c-2-3p	93.7747	NM_018040
GPATCH2	hsa-miR-6788-5p	93.7747	NM_018040
GPATCH2	hsa-miR-3977	93.6694	NM_018040
GPATCH2	hsa-miR-4495	93.3327	NM_001297754
GPATCH2	hsa-miR-548e-5p	93.1676	NM_018040
GPATCH2	hsa-miR-561-5p	93.1584	NM_018040
GPATCH2	hsa-miR-302a-5p	91.1156	NM_018040
GPATCH2	hsa-miR-3672	90.2435	NM_018040
GPATCH2	hsa-miR-6864-3p	90.2435	NM_018040
GPATCH2	hsa-miR-766-3p	90.1666	NM_001297754
GPATCH2	hsa-miR-548z	89.9332	NM_001297754
GPATCH2	hsa-miR-548ac	89.9332	NM_001297754
GPATCH2	hsa-miR-548d-3p	89.9332	NM_001297754
GPATCH2	hsa-miR-548bb-3p	89.9332	NM_001297754
GPATCH2	hsa-miR-548h-3p	89.9332	NM_001297754
GPATCH2	hsa-miR-4500	89.9291	NM_018040
GPATCH2	hsa-miR-20a-5p	89.7725	NM_018040
GPATCH2	hsa-miR-106b-5p	89.7725	NM_018040
GPATCH2	hsa-miR-29a-3p	89.586	NM_018040
GPATCH2	hsa-miR-29c-3p	89.586	NM_018040
GPATCH2	hsa-miR-29b-3p	89.586	NM_018040
GPATCH2	hsa-miR-101-3p	89.2632	NM_001297754
GPATCH2	hsa-miR-5571-5p	88.1783	NM_018040
GPATCH2	hsa-miR-6731-3p	87.648	NM_018040
GPATCH2	hsa-miR-767-3p	87.2869	NM_018040
GPATCH2	hsa-miR-892c-5p	86.6263	NM_001297754
GPATCH2	hsa-miR-194-5p	86.2018	NM_018040
GPATCH2	hsa-miR-450a-1-3p	85.9899	NM_018040
GPATCH2	hsa-miR-7-2-3p	85.8462	NM_018040
GPATCH2	hsa-miR-7-1-3p	85.8462	NM_018040
GPATCH2	hsa-miR-20b-5p	85.8024	NM_018040
GPATCH2	hsa-miR-526b-3p	85.8024	NM_018040
GPATCH2	hsa-miR-17-5p	85.8024	NM_018040
GPATCH2	hsa-miR-519d-3p	85.8024	NM_018040
GPATCH2	hsa-miR-106a-5p	85.8024	NM_018040
GPATCH2	hsa-miR-93-5p	85.8024	NM_018040
GPATCH2	hsa-miR-548c-3p	85.798	NM_001297754
GPATCH2	hsa-miR-513c-5p	85.7759	NM_018040
GPATCH2	hsa-miR-514b-5p	85.7759	NM_018040
GPATCH2	hsa-miR-548aj-3p	85.7385	NM_001297754

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Motifs and transcription factors (TFs) regulating GPATCH2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPATCH2	tfdimers__MD00038	TFAP2C (directAnnotation).
GPATCH2	metacluster_175.1	ZNF283 (directAnnotation).
GPATCH2	metacluster_151.2	ZNF23 (directAnnotation).
GPATCH2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
GPATCH2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
GPATCH2	hdpi__TP73	TP73 (directAnnotation).
GPATCH2	jaspar__MA0748.2	YY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."