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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GATM

Summary for GATM

Gene information	Gene symbol	GATM
	Ensembl ID	ENSG00000171766
	Entrez ID	2628
	Gene name	glycine amidinotransferase
	Synonyms	AGAT
	Gene type	protein_coding
	UniProtAcc	P50440

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Dataset with differentially expressed gene: GATM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.4366	4.07e-19

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Expression of GATM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GATM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GATM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GATM	hsa-miR-3978	99.2386	NM_001321015
GATM	hsa-let-7c-5p	98.6306	NM_001321015
GATM	hsa-miR-98-5p	98.6306	NM_001321015
GATM	hsa-let-7e-5p	98.6306	NM_001321015
GATM	hsa-let-7a-5p	98.6306	NM_001321015
GATM	hsa-let-7f-5p	98.6306	NM_001321015
GATM	hsa-let-7g-5p	98.4526	NM_001321015
GATM	hsa-let-7b-5p	98.4526	NM_001321015
GATM	hsa-let-7i-5p	98.4526	NM_001321015
GATM	hsa-miR-4500	98.4422	NM_001321015
GATM	hsa-miR-4458	98.4003	NM_001321015
GATM	hsa-let-7d-5p	98.4003	NM_001321015
GATM	hsa-miR-4786-3p	97.0212	NM_001321015
GATM	hsa-miR-4257	96.4783	NM_001321015
GATM	hsa-miR-4768-5p	96.4661	NM_001321015
GATM	hsa-miR-19a-5p	96.3535	NM_001321015
GATM	hsa-miR-19b-1-5p	96.3535	NM_001321015
GATM	hsa-miR-19b-2-5p	96.3535	NM_001321015
GATM	hsa-miR-6833-3p	95.8289	NM_001321015
GATM	hsa-miR-6835-3p	95.0318	NM_001321015
GATM	hsa-miR-548n	94.7657	NM_001321015
GATM	hsa-miR-7843-3p	94.4782	NM_001321015
GATM	hsa-miR-5692a	94.3278	NM_001321015
GATM	hsa-miR-6882-3p	94.0991	NM_001321015
GATM	hsa-miR-22-3p	94.0181	NM_001321015
GATM	hsa-miR-30d-5p	92.5994	NM_001321015
GATM	hsa-miR-30e-5p	92.5994	NM_001321015
GATM	hsa-miR-30b-5p	92.5994	NM_001321015
GATM	hsa-miR-30c-5p	92.5994	NM_001321015
GATM	hsa-miR-30a-5p	92.5994	NM_001321015
GATM	hsa-miR-561-3p	91.4628	NM_001321015
GATM	hsa-miR-6845-3p	91.0149	NM_001321015
GATM	hsa-miR-507	90.6211	NM_001321015
GATM	hsa-miR-8069	90.5009	NM_001321015
GATM	hsa-miR-3148	89.9801	NM_001321015
GATM	hsa-miR-154-5p	89.8436	NM_001321015
GATM	hsa-miR-557	89.5891	NM_001321015
GATM	hsa-miR-153-3p	89.3428	NM_001321015
GATM	hsa-miR-1323	88.6584	NM_001321015
GATM	hsa-miR-4445-5p	88.4124	NM_001321015
GATM	hsa-miR-127-5p	88.0206	NM_001321015
GATM	hsa-miR-543	87.3953	NM_001321015
GATM	hsa-miR-548o-3p	85.2333	NM_001321015
GATM	hsa-miR-651-5p	85.1817	NM_001321015
GATM	hsa-miR-3927-3p	85.0679	NM_001321015
GATM	hsa-miR-6831-5p	85.0679	NM_001321015
GATM	hsa-miR-6499-3p	84.7565	NM_001321015
GATM	hsa-miR-4266	84.5284	NM_001321015
GATM	hsa-miR-203a-3p	84.4685	NM_001321015
GATM	hsa-miR-498-5p	84.1666	NM_001321015

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Motifs and transcription factors (TFs) regulating GATM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GATM	metacluster_135.11	NR2C2 (directAnnotation).
GATM	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
GATM	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
GATM	metacluster_7.13	ZFX (directAnnotation).
GATM	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
GATM	cisbp__M00968	MTF2 (directAnnotation).
GATM	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GATM	metacluster_160.20	JUND; PRDM15 (directAnnotation).
GATM	metacluster_198.3	ZFP64 (directAnnotation).
GATM	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
GATM	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GATM	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
GATM	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
GATM	cisbp__M00788	ZFY (inferredBy_Orthology).
GATM	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
GATM	metacluster_175.1	ZNF283 (directAnnotation).
GATM	hdpi__ZNF304	ZNF304 (directAnnotation).
GATM	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
GATM	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GATM	transfac_pro__M01199	TRIM28 (directAnnotation).
GATM	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
GATM	metacluster_151.2	ZNF23 (directAnnotation).
GATM	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GATM	transfac_pro__M03806	ZBTB7C (directAnnotation).
GATM	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GATM	"Alpha-Aminobutyric Acid"	DB04454	small molecule
GATM	"Delta-Amino Valeric Acid"	DB02068	small molecule
GATM	"gamma-Aminobutyric acid"	DB02530	small molecule
GATM	"Glycine"	DB00145	small molecule
GATM	"Norvaline"	DB04185	small molecule
GATM	"Ornithine"	DB00129	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."