Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FRS2

Summary for FRS2

Gene information	Gene symbol	FRS2
	Ensembl ID	ENSG00000166225
	Entrez ID	10818
	Gene name	fibroblast growth factor receptor substrate 2
	Synonyms	FRS2A\|FRS2alpha\|SNT-1\|SNT1
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: FRS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.43575	0.00e+00

Top

Expression of FRS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to FRS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating FRS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FRS2	hsa-miR-182-5p	99.8722	NM_001042555
FRS2	hsa-miR-96-5p	99.682	NM_001042555
FRS2	hsa-miR-1271-5p	99.6078	NM_001042555
FRS2	hsa-miR-12133	99.5123	NM_001042555
FRS2	hsa-miR-98-3p	99.4792	NM_001042555
FRS2	hsa-let-7f-1-3p	99.426	NM_001042555
FRS2	hsa-let-7b-3p	99.426	NM_001042555
FRS2	hsa-let-7a-3p	99.426	NM_001042555
FRS2	hsa-miR-4666a-3p	98.8953	NM_001042555
FRS2	hsa-miR-33a-3p	98.4156	NM_001042555
FRS2	hsa-miR-3163	97.9898	NM_001042555
FRS2	hsa-miR-204-5p	97.6234	NM_001042555
FRS2	hsa-miR-211-5p	97.6234	NM_001042555
FRS2	hsa-miR-4796-5p	97.3095	NM_001042555
FRS2	hsa-miR-106b-5p	96.7147	NM_001042555
FRS2	hsa-miR-20a-5p	96.7147	NM_001042555
FRS2	hsa-miR-2355-3p	96.5977	NM_001042555
FRS2	hsa-miR-153-5p	96.2545	NM_001278354
FRS2	hsa-miR-4255	96.0823	NM_001278354
FRS2	hsa-miR-17-5p	96.0271	NM_001042555
FRS2	hsa-miR-526b-3p	96.0271	NM_001042555
FRS2	hsa-miR-93-5p	96.0271	NM_001042555
FRS2	hsa-miR-106a-5p	96.0271	NM_001042555
FRS2	hsa-miR-519d-3p	96.0271	NM_001042555
FRS2	hsa-miR-20b-5p	96.0271	NM_001042555
FRS2	hsa-miR-1303	95.66	NM_001042555
FRS2	hsa-miR-3609	95.4414	NM_001042555
FRS2	hsa-miR-548ah-5p	95.4414	NM_001042555
FRS2	hsa-miR-196a-3p	95.4056	NM_001278354
FRS2	hsa-miR-3646	95.1522	NM_001278354
FRS2	hsa-miR-6508-5p	95.015	NM_001278354
FRS2	hsa-miR-5589-3p	94.9728	NM_001042555
FRS2	hsa-miR-192-3p	94.9167	NM_001278354
FRS2	hsa-miR-548x-3p	94.5666	NM_001278354
FRS2	hsa-miR-548aj-3p	94.5666	NM_001278354
FRS2	hsa-miR-5006-3p	94.5576	NM_001042555
FRS2	hsa-miR-4755-5p	94.5576	NM_001042555
FRS2	hsa-miR-3925-5p	94.1982	NM_001278354
FRS2	hsa-miR-623	94.1386	NM_001042555
FRS2	hsa-miR-3938	94.0544	NM_001042555
FRS2	hsa-miR-206	93.1471	NM_001042555
FRS2	hsa-miR-1-3p	93.1471	NM_001042555
FRS2	hsa-miR-187-5p	93.1253	NM_001278354
FRS2	hsa-miR-613	93.1137	NM_001042555
FRS2	hsa-miR-381-3p	93.0712	NM_001042555
FRS2	hsa-miR-300	93.0712	NM_001042555
FRS2	hsa-miR-8067	92.9739	NM_001278354
FRS2	hsa-miR-4770	92.7648	NM_001042555
FRS2	hsa-miR-143-3p	92.7648	NM_001042555
FRS2	hsa-miR-5680	92.3798	NM_001278354

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating FRS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FRS2	metacluster_135.11	NR2C2 (directAnnotation).
FRS2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FRS2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FRS2	metacluster_7.13	ZFX (directAnnotation).
FRS2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FRS2	cisbp__M00968	MTF2 (directAnnotation).
FRS2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FRS2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FRS2	cisbp__M00341	PAX6 (directAnnotation).
FRS2	metacluster_198.3	ZFP64 (directAnnotation).
FRS2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FRS2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FRS2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FRS2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FRS2	cisbp__M00788	ZFY (inferredBy_Orthology).
FRS2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FRS2	metacluster_175.1	ZNF283 (directAnnotation).
FRS2	hdpi__ZNF304	ZNF304 (directAnnotation).
FRS2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FRS2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FRS2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FRS2	transfac_pro__M01199	TRIM28 (directAnnotation).
FRS2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FRS2	metacluster_151.2	ZNF23 (directAnnotation).
FRS2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FRS2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FRS2	transfac_pro__M03806	ZBTB7C (directAnnotation).
FRS2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."