Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM168B

Summary for FAM168B

Gene information	Gene symbol	FAM168B
	Ensembl ID	ENSG00000152102
	Entrez ID	130074
	Gene name	family with sequence similarity 168 member B
	Synonyms	KIAA0280L\|MANI
	Gene type	protein_coding
	UniProtAcc	A1KXE4

Top

Dataset with differentially expressed gene: FAM168B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.439974	1.86e-28
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.315858	2.82e-26

Top

Expression of FAM168B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to FAM168B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating FAM168B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM168B	hsa-miR-448	98.6255	NM_001009993
FAM168B	hsa-miR-153-3p	98.4451	NM_001009993
FAM168B	hsa-miR-3680-3p	98.3328	NM_001009993
FAM168B	hsa-miR-141-3p	97.4484	NM_001009993
FAM168B	hsa-miR-200a-3p	97.4484	NM_001009993
FAM168B	hsa-miR-3148	96.5731	NM_001009993
FAM168B	hsa-miR-2467-3p	96.1263	NM_001009993
FAM168B	hsa-miR-17-3p	95.8272	NM_001009993
FAM168B	hsa-miR-24-3p	95.5831	NM_001009993
FAM168B	hsa-miR-152-3p	94.7996	NM_001009993
FAM168B	hsa-miR-148b-3p	94.7996	NM_001009993
FAM168B	hsa-miR-148a-3p	94.7996	NM_001009993
FAM168B	hsa-miR-1207-3p	94.6695	NM_001009993
FAM168B	hsa-miR-3163	94.6111	NM_001009993
FAM168B	hsa-miR-4659b-3p	94.3494	NM_001009993
FAM168B	hsa-miR-4659a-3p	94.3494	NM_001009993
FAM168B	hsa-miR-548av-5p	93.3775	NM_001009993
FAM168B	hsa-miR-8054	93.3775	NM_001009993
FAM168B	hsa-miR-548k	93.3775	NM_001009993
FAM168B	hsa-miR-3671	92.8307	NM_001009993
FAM168B	hsa-miR-4443	92.3809	NM_001009993
FAM168B	hsa-miR-553	92.2857	NM_001009993
FAM168B	hsa-miR-3934-3p	91.7536	NM_001009993
FAM168B	hsa-miR-3121-5p	91.2934	NM_001009993
FAM168B	hsa-miR-5689	91.1998	NM_001009993
FAM168B	hsa-miR-4426	91.0809	NM_001009993
FAM168B	hsa-miR-6832-3p	90.9683	NM_001009993
FAM168B	hsa-miR-302e	90.4385	NM_001009993
FAM168B	hsa-miR-4647	90.1461	NM_001009993
FAM168B	hsa-miR-212-5p	90.1407	NM_001009993
FAM168B	hsa-miR-29b-3p	89.9363	NM_001009993
FAM168B	hsa-miR-29c-3p	89.9363	NM_001009993
FAM168B	hsa-miR-29a-3p	89.9363	NM_001009993
FAM168B	hsa-miR-150-5p	89.0488	NM_001009993
FAM168B	hsa-miR-548av-3p	88.8143	NM_001009993
FAM168B	hsa-miR-28-3p	88.5958	NM_001009993
FAM168B	hsa-miR-302b-3p	88.3556	NM_001009993
FAM168B	hsa-miR-302c-3p	88.3556	NM_001009993
FAM168B	hsa-miR-302a-3p	88.3556	NM_001009993
FAM168B	hsa-miR-302d-3p	88.3556	NM_001009993
FAM168B	hsa-miR-302b-5p	88.1773	NM_001009993
FAM168B	hsa-miR-8068	88.0554	NM_001009993
FAM168B	hsa-miR-149-5p	87.8733	NM_001009993
FAM168B	hsa-miR-10394-5p	87.7783	NM_001009993
FAM168B	hsa-miR-1205	87.7783	NM_001009993
FAM168B	hsa-miR-204-5p	87.6822	NM_001009993
FAM168B	hsa-miR-211-5p	87.6822	NM_001009993
FAM168B	hsa-miR-509-5p	87.0606	NM_001009993
FAM168B	hsa-miR-509-3-5p	87.0606	NM_001009993
FAM168B	hsa-miR-4418	87.06	NM_001009993

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating FAM168B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM168B	metacluster_135.11	NR2C2 (directAnnotation).
FAM168B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FAM168B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FAM168B	metacluster_7.13	ZFX (directAnnotation).
FAM168B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FAM168B	cisbp__M00968	MTF2 (directAnnotation).
FAM168B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FAM168B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FAM168B	cisbp__M00341	PAX6 (directAnnotation).
FAM168B	metacluster_198.3	ZFP64 (directAnnotation).
FAM168B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FAM168B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FAM168B	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FAM168B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FAM168B	cisbp__M00788	ZFY (inferredBy_Orthology).
FAM168B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FAM168B	metacluster_175.1	ZNF283 (directAnnotation).
FAM168B	hdpi__ZNF304	ZNF304 (directAnnotation).
FAM168B	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FAM168B	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FAM168B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FAM168B	transfac_pro__M01199	TRIM28 (directAnnotation).
FAM168B	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FAM168B	metacluster_151.2	ZNF23 (directAnnotation).
FAM168B	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FAM168B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FAM168B	transfac_pro__M03806	ZBTB7C (directAnnotation).
FAM168B	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FAM168B	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
FAM168B	transfac_pro__M01253	CNOT3 (directAnnotation).
FAM168B	metacluster_134.7	FOXD2; FOXG1; FOXI1; FOXJ2; FOXJ2; FOXJ3; FOXJ3; FOXK1; FOXK1; FOXK2; FOXO4; FOXO6; FOXP2 (directAnnotation). FOXC1; FOXO1; FOXO6 (inferredBy_Orthology).
FAM168B	transfac_pro__M04817	ZBTB33 (directAnnotation).
FAM168B	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
FAM168B	transfac_pro__M05712	ZNF134 (directAnnotation).
FAM168B	cisbp__M07938	E2F1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."