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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ETV1

Summary for ETV1

Gene information	Gene symbol	ETV1
	Ensembl ID	ENSG00000006468
	Entrez ID	2115
	Gene name	ETS variant transcription factor 1
	Synonyms	ER81
	Gene type	protein_coding
	UniProtAcc	P50549

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Dataset with differentially expressed gene: ETV1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-1.26515	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.35094	1.42e-19
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.264501	5.73e-06

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Expression of ETV1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ETV1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ETV1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ETV1	hsa-miR-10527-5p	99.5975	NM_001163147
ETV1	hsa-miR-4677-5p	99.4257	NM_001163149
ETV1	hsa-miR-4311	99.3122	NM_001163147
ETV1	hsa-miR-582-5p	97.7568	NM_001163147
ETV1	hsa-miR-5692a	97.6341	NM_001163147
ETV1	hsa-miR-122b-5p	97.4403	NM_001163149
ETV1	hsa-miR-7856-5p	96.9887	NM_001163147
ETV1	hsa-miR-3163	96.9578	NM_001163147
ETV1	hsa-miR-8055	96.7584	NM_001163149
ETV1	hsa-miR-4795-3p	96.4355	NM_001163149
ETV1	hsa-miR-9983-3p	96.1343	NM_001163149
ETV1	hsa-miR-522-3p	95.9657	NM_001163147
ETV1	hsa-miR-224-3p	95.9657	NM_001163147
ETV1	hsa-miR-298	94.9095	NM_001163147
ETV1	hsa-miR-2355-3p	94.7391	NM_001163149
ETV1	hsa-miR-5010-3p	94.5145	NM_001163149
ETV1	hsa-miR-3120-3p	94.4965	NM_001163149
ETV1	hsa-miR-126-5p	94.3263	NM_001163149
ETV1	hsa-miR-590-3p	94.0291	NM_001163149
ETV1	hsa-miR-3942-5p	93.8891	NM_001163147
ETV1	hsa-miR-4703-5p	93.8713	NM_001163147
ETV1	hsa-miR-587	93.7813	NM_001163149
ETV1	hsa-miR-129-5p	93.4646	NM_001163149
ETV1	hsa-miR-4672	92.1525	NM_001163149
ETV1	hsa-miR-106b-5p	91.761	NM_001163147
ETV1	hsa-miR-20a-5p	91.761	NM_001163147
ETV1	hsa-miR-302c-5p	91.7144	NM_001163147
ETV1	hsa-miR-223-5p	91.6421	NM_001163149
ETV1	hsa-miR-190a-3p	91.6248	NM_001163149
ETV1	hsa-miR-551b-5p	91.6217	NM_001163147
ETV1	hsa-miR-888-5p	91.5796	NM_001163147
ETV1	hsa-miR-7159-3p	91.4395	NM_001163149
ETV1	hsa-miR-12136	91.4343	NM_001163147
ETV1	hsa-miR-335-3p	91.3578	NM_001163147
ETV1	hsa-miR-4503	91.3557	NM_001163147
ETV1	hsa-miR-196a-1-3p	91.2253	NM_001163149
ETV1	hsa-miR-4775	90.87	NM_001163149
ETV1	hsa-miR-4279	90.584	NM_001163149
ETV1	hsa-miR-3201	90.4701	NM_001163147
ETV1	hsa-miR-3123	90.3401	NM_001163147
ETV1	hsa-miR-93-5p	89.7664	NM_001163147
ETV1	hsa-miR-519d-3p	89.7664	NM_001163147
ETV1	hsa-miR-17-5p	89.7664	NM_001163147
ETV1	hsa-miR-526b-3p	89.7664	NM_001163147
ETV1	hsa-miR-20b-5p	89.7664	NM_001163147
ETV1	hsa-miR-106a-5p	89.7664	NM_001163147
ETV1	hsa-miR-4294	89.7302	NM_001163149
ETV1	hsa-miR-548p	89.6747	NM_001163149
ETV1	hsa-miR-548av-3p	89.6126	NM_001163147
ETV1	hsa-miR-548g-3p	89.5596	NM_001163147

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Motifs and transcription factors (TFs) regulating ETV1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ETV1	jaspar__MA0079.5	SP1 (directAnnotation).
ETV1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
ETV1	transfac_pro__M05791	ZNF517 (directAnnotation).
ETV1	hdpi__NFIX	NFIX (directAnnotation).
ETV1	metacluster_26.7	MYNN; MYNN (directAnnotation).
ETV1	transfac_pro__M01835	KLF4 (directAnnotation).
ETV1	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
ETV1	swissregulon__hs__MTA3	MTA3 (directAnnotation).
ETV1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ETV1	metacluster_191.3	up	Malignant cells	GSE131984_JQ1Pal	NA
ETV1	metacluster_166.4	up	Malignant cells	GSE131984_JQ1Pal	NA
ETV1	metacluster_166.2	up	Malignant cells	GSE131984_JQ1Pal	NA
ETV1	metacluster_138.2	up	Malignant cells	GSE131984_JQ1Pal	NA
ETV1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	up	Malignant cells	GSE131984_JQ1Pal	NA
ETV1	metacluster_191.3	up	Malignant cells	GSE131984_Pal	NA
ETV1	metacluster_166.4	up	Malignant cells	GSE131984_Pal	NA
ETV1	metacluster_166.2	up	Malignant cells	GSE131984_Pal	NA
ETV1	metacluster_138.2	up	Malignant cells	GSE131984_Pal	NA
ETV1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	up	Malignant cells	GSE131984_Pal	NA
ETV1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	up	Malignant cells	GSE131984_Pal	NA
ETV1	metacluster_166.2	down	Malignant cells	GSE168668	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."