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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EREG

Summary for EREG

Gene information	Gene symbol	EREG
	Ensembl ID	ENSG00000124882
	Entrez ID	2069
	Gene name	epiregulin
	Synonyms	ER
	Gene type	protein_coding
	UniProtAcc	O14944

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Dataset with differentially expressed gene: EREG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-1.20259	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.872565	9.07e-10
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.996065	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Mono/Macro	0.860466	3.28e-40
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.280356	1.45e-05
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Mono/Macro	-0.36684	1.06e-26
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.20964	4.72e-07

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Expression of EREG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EREG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
EREG	Mono/Macro	CPI-SS004C23DCE	EREG_EGFR	EREG	EGFR	False	Mono/Macro	Endothelial cells	GSE207422_Tor	post	resistant
EREG	Mono/Macro	CPI-SS004C23DCE	EREG_EGFR	EREG	EGFR	False	Mono/Macro	Malignant cells	GSE207422_Tor	post	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
EREG	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating EREG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EREG	hsa-miR-4795-3p	99.2149	NM_001432
EREG	hsa-miR-126-5p	97.8853	NM_001432
EREG	hsa-miR-130a-3p	96.941	NM_001432
EREG	hsa-miR-1277-5p	96.3598	NM_001432
EREG	hsa-miR-4295	96.1214	NM_001432
EREG	hsa-miR-454-3p	96.1214	NM_001432
EREG	hsa-miR-301a-3p	96.1214	NM_001432
EREG	hsa-miR-130b-3p	96.1214	NM_001432
EREG	hsa-miR-301b-3p	96.1214	NM_001432
EREG	hsa-miR-3666	96.1214	NM_001432
EREG	hsa-miR-4803	95.3311	NM_001432
EREG	hsa-miR-656-3p	94.6364	NM_001432
EREG	hsa-miR-4666a-3p	94.025	NM_001432
EREG	hsa-miR-7856-5p	93.6004	NM_001432
EREG	hsa-miR-3928-3p	93.3951	NM_001432
EREG	hsa-miR-543	92.95	NM_001432
EREG	hsa-miR-5011-5p	91.816	NM_001432
EREG	hsa-miR-3646	91.2886	NM_001432
EREG	hsa-miR-548c-3p	91.2154	NM_001432
EREG	hsa-miR-12136	90.607	NM_001432
EREG	hsa-miR-568	90.2635	NM_001432
EREG	hsa-miR-643	90.2345	NM_001432
EREG	hsa-miR-2116-3p	90.0259	NM_001432
EREG	hsa-miR-548aj-3p	89.7585	NM_001432
EREG	hsa-miR-548x-3p	89.7585	NM_001432
EREG	hsa-miR-215-5p	89.5602	NM_001432
EREG	hsa-miR-192-5p	89.5602	NM_001432
EREG	hsa-miR-889-3p	88.9919	NM_001432
EREG	hsa-miR-1468-3p	88.8303	NM_001432
EREG	hsa-miR-215-3p	88.63	NM_001432
EREG	hsa-miR-3613-3p	87.6183	NM_001432
EREG	hsa-miR-335-3p	87.5857	NM_001432
EREG	hsa-miR-106a-5p	87.4034	NM_001432
EREG	hsa-miR-17-5p	87.4034	NM_001432
EREG	hsa-miR-586	86.5197	NM_001432
EREG	hsa-miR-19a-3p	86.4792	NM_001432
EREG	hsa-miR-19b-3p	86.4792	NM_001432
EREG	hsa-miR-6773-3p	86.3491	NM_001432
EREG	hsa-miR-4749-3p	85.6013	NM_001432
EREG	hsa-miR-548j-3p	84.9453	NM_001432
EREG	hsa-miR-548ae-3p	84.9453	NM_001432
EREG	hsa-miR-548aq-3p	84.9453	NM_001432
EREG	hsa-miR-548ah-3p	84.9453	NM_001432
EREG	hsa-miR-548am-3p	84.9453	NM_001432
EREG	hsa-miR-519b-3p	84.7491	NM_001432
EREG	hsa-miR-519a-3p	84.7491	NM_001432
EREG	hsa-miR-519c-3p	84.7491	NM_001432
EREG	hsa-miR-6715a-3p	84.6415	NM_001432
EREG	hsa-miR-4673	84.3736	NM_001432
EREG	hsa-miR-4645-5p	84.3736	NM_001432

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Motifs and transcription factors (TFs) regulating EREG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EREG	transfac_pro__M05667	ZNF35 (directAnnotation).
EREG	metacluster_53.2	ZNF8 (directAnnotation).
EREG	transfac_pro__M05744	ZXDC (directAnnotation).
EREG	transfac_pro__M04706	RELA (directAnnotation).
EREG	metacluster_92.3	ZNF354A (directAnnotation). ZNF354B (inferredBy_Orthology).
EREG	transfac_pro__M06577	ZNF594 (directAnnotation).
EREG	metacluster_14.11	MITF; TFE3 (inferredBy_Orthology).
EREG	transfac_pro__M05647	ZNF875 (directAnnotation).
EREG	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
EREG	metacluster_65.8	ZNF343 (directAnnotation).
EREG	transfac_pro__M05607	MYBL1 (directAnnotation).
EREG	metacluster_22.42	MAFG (directAnnotation).
EREG	metacluster_172.22	E4F1 (inferredBy_Orthology).
EREG	metacluster_76.1	ZNF345; ZNF345 (directAnnotation). MYB; MYBL1 (inferredBy_Orthology).
EREG	transfac_pro__M04955	ZBTB33 (directAnnotation).
EREG	transfac_pro__M05916	ZNF407 (directAnnotation).
EREG	transfac_pro__M06180	ZNF445 (directAnnotation).
EREG	tfdimers__MD00069	IKZF1; PDX1 (directAnnotation).
EREG	hdpi__ETS1	ETS1 (directAnnotation).
EREG	metacluster_79.31	ZNF708; ZNF708; ZNF708 (directAnnotation).
EREG	tfdimers__MD00449	REL; YY1 (directAnnotation).
EREG	metacluster_155.13	ZNF135 (directAnnotation).
EREG	transfac_pro__M06609	ZKSCAN4 (directAnnotation).
EREG	cisbp__M02385	MYRF (directAnnotation).
EREG	metacluster_172.5	FOXD4L1; FOXD4L6 (directAnnotation). FOXD1; FOXD2; FOXD4; FOXD4L1; FOXD4L3; FOXD4L4; FOXD4L5; FOXD4L6 (inferredBy_Orthology).
EREG	transfac_pro__M06764	ZNF112 (directAnnotation).
EREG	metacluster_47.1	E4F1; SPDEF; SPDEF (directAnnotation).
EREG	metacluster_22.39	NFE2L2 (directAnnotation).
EREG	metacluster_135.11	NR2C2 (directAnnotation).
EREG	cisbp__M00341	PAX6 (directAnnotation).
EREG	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
EREG	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
EREG	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
EREG	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
EREG	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
EREG	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
EREG	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
EREG	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
EREG	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
EREG	metacluster_168.4	ZNF652 (directAnnotation).
EREG	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
EREG	transfac_pro__M06550	ZNF519 (directAnnotation).
EREG	transfac_public__M00039	CREB1 (directAnnotation).
EREG	transfac_pro__M08803	CREM (directAnnotation).
EREG	transfac_pro__M06104	ZNF16 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."