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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ERBIN

Summary for ERBIN

Gene information	Gene symbol	ERBIN
	Ensembl ID	ENSG00000112851
	Entrez ID	55914
	Gene name	erbb2 interacting protein
	Synonyms	ERBB2IP\|LAP2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ERBIN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.271894	2.84e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.405739	4.03e-37

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Expression of ERBIN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ERBIN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ERBIN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ERBIN	hsa-miR-4282	99.8122	NM_001006600
ERBIN	hsa-miR-3163	99.7297	NM_001006600
ERBIN	hsa-miR-548c-3p	99.5704	NM_001006600
ERBIN	hsa-miR-1284	97.5833	NM_001006600
ERBIN	hsa-miR-4659a-3p	96.8923	NM_001006600
ERBIN	hsa-miR-4659b-3p	96.8923	NM_001006600
ERBIN	hsa-miR-101-3p	96.8186	NM_001006600
ERBIN	hsa-miR-548d-3p	96.5615	NM_001006600
ERBIN	hsa-miR-590-3p	96.268	NM_001006600
ERBIN	hsa-miR-519c-3p	95.9997	NM_001006600
ERBIN	hsa-miR-519b-3p	95.9997	NM_001006600
ERBIN	hsa-miR-519a-3p	95.9997	NM_001006600
ERBIN	hsa-miR-551b-5p	95.7396	NM_001006600
ERBIN	hsa-miR-548aj-3p	95.6621	NM_001006600
ERBIN	hsa-miR-548x-3p	95.6621	NM_001006600
ERBIN	hsa-miR-548bb-3p	95.5061	NM_001006600
ERBIN	hsa-miR-548z	95.5061	NM_001006600
ERBIN	hsa-miR-548h-3p	95.5061	NM_001006600
ERBIN	hsa-miR-548ac	95.5061	NM_001006600
ERBIN	hsa-miR-137-3p	95.4455	NM_001006600
ERBIN	hsa-miR-548n	95.3723	NM_001006600
ERBIN	hsa-miR-4424	95.2547	NM_001006600
ERBIN	hsa-miR-202-5p	95.0279	NM_001006600
ERBIN	hsa-let-7c-3p	94.9088	NM_001006600
ERBIN	hsa-miR-130b-3p	94.8118	NM_001006600
ERBIN	hsa-miR-301b-3p	94.8118	NM_001006600
ERBIN	hsa-miR-3666	94.8118	NM_001006600
ERBIN	hsa-miR-130a-3p	94.8118	NM_001006600
ERBIN	hsa-miR-301a-3p	94.8118	NM_001006600
ERBIN	hsa-miR-4295	94.8118	NM_001006600
ERBIN	hsa-miR-454-3p	94.8118	NM_001006600
ERBIN	hsa-miR-548p	94.0532	NM_001006600
ERBIN	hsa-miR-944	93.8605	NM_001006600
ERBIN	hsa-miR-548ar-3p	93.5661	NM_001006600
ERBIN	hsa-miR-23a-3p	93.5311	NM_001006600
ERBIN	hsa-miR-23c	93.5311	NM_001006600
ERBIN	hsa-miR-23b-3p	93.5311	NM_001006600
ERBIN	hsa-miR-1278	93.503	NM_001006600
ERBIN	hsa-miR-190a-3p	93.2178	NM_001006600
ERBIN	hsa-miR-548aq-3p	93.2007	NM_001006600
ERBIN	hsa-miR-548ah-3p	93.2007	NM_001006600
ERBIN	hsa-miR-548j-3p	93.2007	NM_001006600
ERBIN	hsa-miR-548am-3p	93.2007	NM_001006600
ERBIN	hsa-miR-548ae-3p	93.2007	NM_001006600
ERBIN	hsa-miR-3613-3p	92.6225	NM_001006600
ERBIN	hsa-miR-5011-5p	92.3352	NM_001006600
ERBIN	hsa-miR-139-5p	91.6064	NM_001006600
ERBIN	hsa-miR-548t-5p	91.3661	NM_001006600
ERBIN	hsa-miR-548az-5p	91.3661	NM_001006600
ERBIN	hsa-miR-3920	91.2769	NM_001006600

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Motifs and transcription factors (TFs) regulating ERBIN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ERBIN	metacluster_135.11	NR2C2 (directAnnotation).
ERBIN	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ERBIN	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ERBIN	metacluster_7.13	ZFX (directAnnotation).
ERBIN	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ERBIN	cisbp__M00968	MTF2 (directAnnotation).
ERBIN	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ERBIN	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ERBIN	cisbp__M00341	PAX6 (directAnnotation).
ERBIN	metacluster_198.3	ZFP64 (directAnnotation).
ERBIN	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ERBIN	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ERBIN	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ERBIN	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ERBIN	cisbp__M00788	ZFY (inferredBy_Orthology).
ERBIN	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ERBIN	metacluster_175.1	ZNF283 (directAnnotation).
ERBIN	hdpi__ZNF304	ZNF304 (directAnnotation).
ERBIN	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ERBIN	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ERBIN	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ERBIN	transfac_pro__M01199	TRIM28 (directAnnotation).
ERBIN	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ERBIN	metacluster_151.2	ZNF23 (directAnnotation).
ERBIN	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ERBIN	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ERBIN	transfac_pro__M03806	ZBTB7C (directAnnotation).
ERBIN	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ERBIN	transfac_pro__M05731	ZNF660 (directAnnotation).
ERBIN	transfac_pro__M06037	ZNF197 (directAnnotation).
ERBIN	taipale__ZNF524_full_ACCCTTGAACCC_repr	ZNF524 (directAnnotation).
ERBIN	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ERBIN	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
ERBIN	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ERBIN	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ERBIN	kznf__ZNF443_Imbeault2017_OM_RCADE	ZNF443 (directAnnotation).
ERBIN	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_1	ELK1; GCM1 (directAnnotation).
ERBIN	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
ERBIN	transfac_pro__M06811	ZNF528 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."