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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EDEM3

Summary for EDEM3

Gene information	Gene symbol	EDEM3
	Ensembl ID	ENSG00000116406
	Entrez ID	80267
	Gene name	ER degradation enhancing alpha-mannosidase like protein 3
	Synonyms	C1orf22
	Gene type	protein_coding
	UniProtAcc	Q9BZQ6

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Dataset with differentially expressed gene: EDEM3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.496158	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.400708	0.00e+00

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Expression of EDEM3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EDEM3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EDEM3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EDEM3	hsa-miR-5582-3p	98.4948	NM_025191
EDEM3	hsa-miR-4699-3p	97.8562	NM_001319960
EDEM3	hsa-miR-3646	96.4422	NM_025191
EDEM3	hsa-miR-3140-5p	96.3087	NM_001319960
EDEM3	hsa-miR-3163	96.2812	NM_001319960
EDEM3	hsa-miR-29b-2-5p	95.3464	NM_001319960
EDEM3	hsa-miR-224-5p	95.2743	NM_001319960
EDEM3	hsa-miR-27b-3p	95.2352	NM_001319960
EDEM3	hsa-miR-27a-3p	95.2352	NM_001319960
EDEM3	hsa-miR-9985	95.2352	NM_001319960
EDEM3	hsa-miR-3529-3p	94.6044	NM_025191
EDEM3	hsa-miR-370-5p	94.499	NM_025191
EDEM3	hsa-miR-5680	94.1807	NM_001319960
EDEM3	hsa-miR-3662	94.0569	NM_025191
EDEM3	hsa-miR-7851-3p	94.0023	NM_001319960
EDEM3	hsa-miR-4668-3p	93.701	NM_001319960
EDEM3	hsa-miR-3065-5p	93.2671	NM_025191
EDEM3	hsa-miR-4446-5p	92.9268	NM_025191
EDEM3	hsa-miR-499b-3p	92.8653	NM_025191
EDEM3	hsa-miR-499a-3p	92.8653	NM_025191
EDEM3	hsa-miR-335-3p	92.8637	NM_025191
EDEM3	hsa-miR-1252-5p	92.665	NM_025191
EDEM3	hsa-miR-3065-3p	92.5395	NM_001319960
EDEM3	hsa-miR-1183	91.3548	NM_025191
EDEM3	hsa-miR-6079	91.2876	NM_001319960
EDEM3	hsa-miR-8087	91.1981	NM_001319960
EDEM3	hsa-miR-190a-3p	91.117	NM_001319960
EDEM3	hsa-miR-659-3p	91.0779	NM_001319960
EDEM3	hsa-miR-183-3p	90.3945	NM_001319960
EDEM3	hsa-miR-145-3p	90.3235	NM_025191
EDEM3	hsa-miR-30c-5p	90.0992	NM_001319960
EDEM3	hsa-miR-30e-5p	90.0992	NM_001319960
EDEM3	hsa-miR-30b-5p	90.0992	NM_001319960
EDEM3	hsa-miR-30d-5p	90.0992	NM_001319960
EDEM3	hsa-miR-30a-5p	90.0992	NM_001319960
EDEM3	hsa-miR-6804-3p	89.5339	NM_001319960
EDEM3	hsa-miR-1297	89.3681	NM_025191
EDEM3	hsa-miR-6778-3p	88.5563	NM_025191
EDEM3	hsa-miR-587	88.2049	NM_001319960
EDEM3	hsa-miR-4500	88.1964	NM_001319960
EDEM3	hsa-miR-3678-3p	88.0839	NM_001319960
EDEM3	hsa-miR-3148	88.0638	NM_025191
EDEM3	hsa-miR-619-3p	87.5175	NM_001319960
EDEM3	hsa-miR-106a-3p	87.4995	NM_025191
EDEM3	hsa-miR-32-5p	86.846	NM_025191
EDEM3	hsa-miR-92b-3p	86.846	NM_025191
EDEM3	hsa-miR-92a-3p	86.846	NM_025191
EDEM3	hsa-miR-3658	86.2605	NM_025191
EDEM3	hsa-let-7e-5p	86.2301	NM_001319960
EDEM3	hsa-let-7f-5p	86.2301	NM_001319960

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Motifs and transcription factors (TFs) regulating EDEM3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EDEM3	metacluster_135.11	NR2C2 (directAnnotation).
EDEM3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
EDEM3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
EDEM3	cisbp__M00968	MTF2 (directAnnotation).
EDEM3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
EDEM3	cisbp__M00341	PAX6 (directAnnotation).
EDEM3	metacluster_198.3	ZFP64 (directAnnotation).
EDEM3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
EDEM3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
EDEM3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
EDEM3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
EDEM3	hdpi__ZNF304	ZNF304 (directAnnotation).
EDEM3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
EDEM3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
EDEM3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
EDEM3	transfac_pro__M01199	TRIM28 (directAnnotation).
EDEM3	metacluster_151.2	ZNF23 (directAnnotation).
EDEM3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
EDEM3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
EDEM3	transfac_pro__M03806	ZBTB7C (directAnnotation).
EDEM3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
EDEM3	swissregulon__hs__ETV6	ETV6 (directAnnotation).
EDEM3	jaspar__MA1483.2	ELF2 (directAnnotation).
EDEM3	hdpi__TP73	TP73 (directAnnotation).
EDEM3	swissregulon__hs__ELF2	ELF2 (directAnnotation).
EDEM3	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
EDEM3	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
EDEM3	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
EDEM3	cisbp__M02645	ETS1 (directAnnotation).
EDEM3	cisbp__M08198	ELF1 (directAnnotation).
EDEM3	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
EDEM3	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
EDEM3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
EDEM3	transfac_pro__M05697	ZNF235 (directAnnotation).
EDEM3	hdpi__ETV4	ETV4 (directAnnotation).
EDEM3	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
EDEM3	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
EDEM3	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
EDEM3	jaspar__MA1933.1	SREBF2 (directAnnotation).
EDEM3	metacluster_27.29	ZNF583 (directAnnotation). ZNF583 (inferredBy_Orthology).
EDEM3	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
EDEM3	metacluster_102.2	ZBED1 (directAnnotation).
EDEM3	transfac_pro__M05711	ZNF37A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."