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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DYRK2

Summary for DYRK2

Gene information	Gene symbol	DYRK2
	Ensembl ID	ENSG00000127334
	Entrez ID	8445
	Gene name	dual specificity tyrosine phosphorylation regulated kinase 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DYRK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	-0.272718	7.05e-08
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.670445	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.348409	0.00e+00

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Expression of DYRK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DYRK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DYRK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DYRK2	hsa-miR-548aj-3p	99.892	NM_003583
DYRK2	hsa-miR-548x-3p	99.892	NM_003583
DYRK2	hsa-miR-548am-3p	99.7611	NM_003583
DYRK2	hsa-miR-548ae-3p	99.7611	NM_003583
DYRK2	hsa-miR-548aq-3p	99.7611	NM_003583
DYRK2	hsa-miR-548ah-3p	99.7611	NM_003583
DYRK2	hsa-miR-548j-3p	99.7611	NM_003583
DYRK2	hsa-miR-548bb-3p	99.3564	NM_003583
DYRK2	hsa-miR-548z	99.3564	NM_003583
DYRK2	hsa-miR-548d-3p	99.3564	NM_003583
DYRK2	hsa-miR-548ac	99.3564	NM_003583
DYRK2	hsa-miR-548h-3p	99.3564	NM_003583
DYRK2	hsa-miR-3163	99.2872	NM_003583
DYRK2	hsa-miR-4795-3p	97.6137	NM_003583
DYRK2	hsa-miR-4672	95.2012	NM_003583
DYRK2	hsa-miR-6797-5p	94.3677	NM_003583
DYRK2	hsa-miR-1249-5p	94.3677	NM_003583
DYRK2	hsa-miR-24-3p	94.105	NM_003583
DYRK2	hsa-miR-4282	94.0826	NM_003583
DYRK2	hsa-miR-512-3p	93.3668	NM_003583
DYRK2	hsa-miR-32-5p	93.193	NM_003583
DYRK2	hsa-miR-4252	93.0188	NM_003583
DYRK2	hsa-miR-126-5p	92.9803	NM_003583
DYRK2	hsa-miR-3159	92.8763	NM_003583
DYRK2	hsa-miR-92a-3p	92.3695	NM_003583
DYRK2	hsa-miR-92b-3p	92.3695	NM_003583
DYRK2	hsa-miR-107	92.1149	NM_003583
DYRK2	hsa-miR-103a-3p	92.1149	NM_003583
DYRK2	hsa-miR-363-3p	91.8913	NM_003583
DYRK2	hsa-miR-25-3p	91.8913	NM_003583
DYRK2	hsa-miR-367-3p	91.8913	NM_003583
DYRK2	hsa-miR-6515-5p	91.4514	NM_003583
DYRK2	hsa-miR-95-5p	91.4433	NM_003583
DYRK2	hsa-miR-4325	91.3425	NM_003583
DYRK2	hsa-miR-600	89.9629	NM_003583
DYRK2	hsa-miR-6715b-3p	89.1371	NM_003583
DYRK2	hsa-miR-6715a-3p	89.0373	NM_003583
DYRK2	hsa-miR-124-3p	88.7688	NM_003583
DYRK2	hsa-miR-506-3p	88.7688	NM_003583
DYRK2	hsa-miR-4999-5p	88.7017	NM_003583
DYRK2	hsa-miR-6791-5p	88.2351	NM_003583
DYRK2	hsa-miR-4292	88.2351	NM_003583
DYRK2	hsa-miR-3678-3p	87.2439	NM_003583
DYRK2	hsa-miR-4328	87.2031	NM_003583
DYRK2	hsa-miR-155-5p	86.7058	NM_003583
DYRK2	hsa-miR-3198	86.5196	NM_003583
DYRK2	hsa-miR-4309	86.5196	NM_003583
DYRK2	hsa-miR-4799-5p	86.473	NM_003583
DYRK2	hsa-miR-340-5p	85.9768	NM_003583
DYRK2	hsa-miR-182-5p	85.5749	NM_003583

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Motifs and transcription factors (TFs) regulating DYRK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DYRK2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
DYRK2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
DYRK2	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
DYRK2	metacluster_3.14	WT1; WT1 (directAnnotation).
DYRK2	cisbp__M07938	E2F1 (directAnnotation).
DYRK2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DYRK2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DYRK2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DYRK2	cisbp__M00968	MTF2 (directAnnotation).
DYRK2	cisbp__M00341	PAX6 (directAnnotation).
DYRK2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DYRK2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
DYRK2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DYRK2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DYRK2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DYRK2	transfac_pro__M01199	TRIM28 (directAnnotation).
DYRK2	metacluster_151.2	ZNF23 (directAnnotation).
DYRK2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DYRK2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DYRK2	jaspar__MA1154.1	ZNF282 (directAnnotation).
DYRK2	transfac_pro__M06115	ZNF28 (directAnnotation).
DYRK2	hdpi__FLI1	FLI1 (directAnnotation).
DYRK2	transfac_pro__M06071	ZNF814 (directAnnotation).
DYRK2	dbtfbs__ZNF660_HEK293_ENCSR283DOU_merged_N1	ZNF660 (directAnnotation).
DYRK2	transfac_pro__M06487	ZNF695 (directAnnotation).
DYRK2	metacluster_63.3	RFX1; RFX2; RFX3; RFX3; RFX3; RFX4; RFX4 (directAnnotation). RFX1; RFX1; RFX2; RFX2; RFX2; RFX3; RFX3; RFX4; RFX4; RFX6; RFX6; RFX6; RFX8; RFX8 (inferredBy_Orthology).
DYRK2	kznf__ZNF334_Imbeault2017_RP_RCADE	ZNF334 (directAnnotation).
DYRK2	metacluster_168.13	ZNF287; ZNF324; ZNF324B (directAnnotation). ZNF287 (inferredBy_Orthology).
DYRK2	taipale_tf_pairs__TEAD4_ERG_RSCGGAANNNNNNNNCATWCC_CAP_repr	ERG; TEAD4 (directAnnotation).
DYRK2	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
DYRK2	transfac_pro__M06786	ZNF646 (directAnnotation).
DYRK2	metacluster_136.2	RFX1; RFX2; RFX2; RFX3; RFX3; RFX4; RFX5; RFX5; RFX5; RFX5; RFX5; RFX5; RFX5; RFX7; RFX7; RFXANK; RFXAP (directAnnotation). RFX3; RFX3; RFX4 (inferredBy_Orthology).
DYRK2	metacluster_31.3	ZSCAN20; ZSCAN29 (directAnnotation).
DYRK2	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
DYRK2	transfac_pro__M06564	ZNF578 (directAnnotation).
DYRK2	jaspar__MA1724.1	RFX6 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."