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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CRIPT

Summary for CRIPT

Gene information	Gene symbol	CRIPT
	Ensembl ID	ENSG00000119878
	Entrez ID	9419
	Gene name	CXXC repeat containing interactor of PDZ3 domain
	Synonyms	HSPC139
	Gene type	protein_coding
	UniProtAcc	Q9P021

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Dataset with differentially expressed gene: CRIPT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.508648	2.75e-04
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.319551	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.265193	3.68e-20
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.535941	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.252323	4.98e-18
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.386725	0.00e+00

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Expression of CRIPT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CRIPT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CRIPT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CRIPT	hsa-miR-651-3p	98.9778	NM_014171
CRIPT	hsa-miR-12120	98.0453	NM_014171
CRIPT	hsa-miR-3529-3p	97.2229	NM_014171
CRIPT	hsa-miR-4778-5p	96.9398	NM_014171
CRIPT	hsa-miR-548l	96.5354	NM_014171
CRIPT	hsa-miR-3613-3p	93.5204	NM_014171
CRIPT	hsa-miR-4452	92.9412	NM_014171
CRIPT	hsa-miR-335-3p	92.1045	NM_014171
CRIPT	hsa-miR-1910-3p	92.0272	NM_014171
CRIPT	hsa-miR-6511a-5p	91.9505	NM_014171
CRIPT	hsa-miR-539-5p	91.8304	NM_014171
CRIPT	hsa-miR-3973	91.6514	NM_014171
CRIPT	hsa-miR-5587-5p	91.2847	NM_014171
CRIPT	hsa-miR-24-3p	89.9397	NM_014171
CRIPT	hsa-miR-4677-5p	89.8864	NM_014171
CRIPT	hsa-miR-4478	89.5765	NM_014171
CRIPT	hsa-miR-616-5p	87.8203	NM_014171
CRIPT	hsa-miR-371b-5p	87.8203	NM_014171
CRIPT	hsa-miR-373-5p	87.8203	NM_014171
CRIPT	hsa-miR-3120-3p	87.263	NM_014171
CRIPT	hsa-miR-4762-3p	87.2138	NM_014171
CRIPT	hsa-miR-5688	87.0541	NM_014171
CRIPT	hsa-miR-4795-3p	86.5603	NM_014171
CRIPT	hsa-miR-6501-3p	86.349	NM_014171
CRIPT	hsa-miR-1303	85.7295	NM_014171
CRIPT	hsa-miR-3977	85.5486	NM_014171
CRIPT	hsa-miR-3187-3p	85.4748	NM_014171
CRIPT	hsa-miR-495-3p	85.4654	NM_014171
CRIPT	hsa-miR-6516-5p	85.4136	NM_014171
CRIPT	hsa-miR-3065-5p	84.8559	NM_014171
CRIPT	hsa-miR-5706	84.7087	NM_014171
CRIPT	hsa-miR-4782-5p	84.7087	NM_014171
CRIPT	hsa-miR-548as-3p	84.6245	NM_014171
CRIPT	hsa-miR-4515	84.454	NM_014171
CRIPT	hsa-miR-548w	84.351	NM_014171
CRIPT	hsa-miR-548ae-5p	84.351	NM_014171
CRIPT	hsa-miR-548y	84.351	NM_014171
CRIPT	hsa-miR-548d-5p	84.351	NM_014171
CRIPT	hsa-miR-548ak	84.351	NM_014171
CRIPT	hsa-miR-548au-5p	84.351	NM_014171
CRIPT	hsa-miR-548ad-5p	84.351	NM_014171
CRIPT	hsa-miR-548b-5p	84.351	NM_014171
CRIPT	hsa-miR-548ar-5p	84.351	NM_014171
CRIPT	hsa-miR-548am-5p	84.351	NM_014171
CRIPT	hsa-miR-548ay-5p	84.351	NM_014171
CRIPT	hsa-miR-548c-5p	84.351	NM_014171
CRIPT	hsa-miR-548h-5p	84.351	NM_014171
CRIPT	hsa-miR-548o-5p	84.351	NM_014171
CRIPT	hsa-miR-548bb-5p	84.351	NM_014171
CRIPT	hsa-miR-4475	84.0827	NM_014171

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Motifs and transcription factors (TFs) regulating CRIPT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CRIPT	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CRIPT	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CRIPT	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CRIPT	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CRIPT	jaspar__MA1483.2	ELF2 (directAnnotation).
CRIPT	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CRIPT	hdpi__ETV4	ETV4 (directAnnotation).
CRIPT	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CRIPT	swissregulon__hs__ELF2	ELF2 (directAnnotation).
CRIPT	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CRIPT	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
CRIPT	transfac_pro__M04826	EP300 (directAnnotation).
CRIPT	hdpi__FLI1	FLI1 (directAnnotation).
CRIPT	jaspar__MA1708.1	ETV7 (directAnnotation).
CRIPT	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CRIPT	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
CRIPT	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
CRIPT	jaspar__MA1933.1	SREBF2 (directAnnotation).
CRIPT	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
CRIPT	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."