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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CREB5

Summary for CREB5

Gene information	Gene symbol	CREB5
	Ensembl ID	ENSG00000146592
	Entrez ID	9586
	Gene name	cAMP responsive element binding protein 5
	Synonyms	CRE-BPA\|H_GS165L15.1
	Gene type	protein_coding
	UniProtAcc	Q02930

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Dataset with differentially expressed gene: CREB5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.46156	2.58e-08
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.484637	3.25e-39
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.262372	9.26e-09
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.582136	1.23e-39
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.389146	3.54e-15
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.267828	4.17e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.570029	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.07529	0.00e+00

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Expression of CREB5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CREB5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CREB5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CREB5	hsa-miR-8485	99.8673	NM_001011666
CREB5	hsa-miR-548c-3p	99.8226	NM_001011666
CREB5	hsa-miR-204-5p	99.4774	NM_001011666
CREB5	hsa-miR-211-5p	99.4774	NM_001011666
CREB5	hsa-miR-410-3p	98.1888	NM_001011666
CREB5	hsa-miR-944	97.8239	NM_001011666
CREB5	hsa-miR-3646	97.8048	NM_001011666
CREB5	hsa-miR-5584-5p	97.7259	NM_001011666
CREB5	hsa-miR-6832-3p	97.0203	NM_001011666
CREB5	hsa-miR-6886-3p	96.9619	NM_001011666
CREB5	hsa-miR-4424	96.6735	NM_001011666
CREB5	hsa-miR-548n	96.4468	NM_001011666
CREB5	hsa-miR-1185-1-3p	96.3227	NM_001011666
CREB5	hsa-let-7f-2-3p	96.3227	NM_001011666
CREB5	hsa-miR-1185-2-3p	96.3227	NM_001011666
CREB5	hsa-miR-1827	95.9636	NM_001011666
CREB5	hsa-miR-1207-3p	95.4452	NM_001011666
CREB5	hsa-miR-1285-3p	95.3297	NM_001011666
CREB5	hsa-miR-938	95.2066	NM_001011666
CREB5	hsa-miR-6885-3p	94.757	NM_001011666
CREB5	hsa-miR-548e-5p	94.7527	NM_001011666
CREB5	hsa-miR-587	94.6117	NM_001011666
CREB5	hsa-miR-5692c	94.488	NM_001011666
CREB5	hsa-miR-5692b	94.488	NM_001011666
CREB5	hsa-miR-519b-3p	94.1745	NM_001011666
CREB5	hsa-miR-519c-3p	94.1745	NM_001011666
CREB5	hsa-miR-519a-3p	94.1745	NM_001011666
CREB5	hsa-miR-365a-3p	93.8894	NM_001011666
CREB5	hsa-miR-365b-3p	93.8894	NM_001011666
CREB5	hsa-miR-6835-3p	93.7735	NM_001011666
CREB5	hsa-miR-9983-3p	93.5124	NM_001011666
CREB5	hsa-miR-607	93.5071	NM_001011666
CREB5	hsa-miR-520f-3p	93.2446	NM_001011666
CREB5	hsa-miR-7515	93.1093	NM_001011666
CREB5	hsa-miR-3187-5p	92.8459	NM_001011666
CREB5	hsa-miR-5189-5p	92.8399	NM_001011666
CREB5	hsa-miR-4520-2-3p	92.8387	NM_001011666
CREB5	hsa-miR-548ar-3p	92.8242	NM_001011666
CREB5	hsa-miR-6860	92.8001	NM_001011666
CREB5	hsa-miR-612	92.8001	NM_001011666
CREB5	hsa-miR-7106-5p	92.5518	NM_001011666
CREB5	hsa-miR-651-3p	92.463	NM_001011666
CREB5	hsa-miR-556-5p	92.3194	NM_001011666
CREB5	hsa-miR-4795-3p	91.8148	NM_001011666
CREB5	hsa-miR-3691-3p	91.7387	NM_001011666
CREB5	hsa-miR-320a-3p	91.7027	NM_001011666
CREB5	hsa-miR-4429	91.7027	NM_001011666
CREB5	hsa-miR-320c	91.7027	NM_001011666
CREB5	hsa-miR-320b	91.7027	NM_001011666
CREB5	hsa-miR-320d	91.7027	NM_001011666

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Motifs and transcription factors (TFs) regulating CREB5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CREB5	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CREB5	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CREB5	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
CREB5	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CREB5	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
CREB5	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
CREB5	cisbp__M02645	ETS1 (directAnnotation).
CREB5	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
CREB5	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CREB5	transfac_pro__M06156	ZNF75D (directAnnotation).
CREB5	taipale_tf_pairs__ETV2_TCF3_CASSTGNNCCGGAWRYN_CAP_repr	ETV2; TCF3 (directAnnotation).
CREB5	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
CREB5	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CREB5	jaspar__MA1483.2	ELF2 (directAnnotation).
CREB5	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
CREB5	cisbp__M00808	MYPOP (inferredBy_Orthology).
CREB5	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
CREB5	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
CREB5	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
CREB5	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
CREB5	cisbp__M08198	ELF1 (directAnnotation).
CREB5	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
CREB5	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CREB5	metacluster_111.5	E4F1; E4F1 (directAnnotation).
CREB5	jaspar__MA1957.1	ELK1 (directAnnotation).
CREB5	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CREB5	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
CREB5	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
CREB5	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
CREB5	jaspar__MA0748.2	YY2 (directAnnotation).
CREB5	jaspar__MA0502.2	NFYB (directAnnotation).
CREB5	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CREB5	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
CREB5	transfac_pro__M04826	EP300 (directAnnotation).
CREB5	swissregulon__hs__ELF2	ELF2 (directAnnotation).
CREB5	jaspar__MA1708.1	ETV7 (directAnnotation).
CREB5	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CREB5	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
CREB5	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
CREB5	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
CREB5	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
CREB5	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
CREB5	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
CREB5	transfac_pro__M01298	MECP2 (directAnnotation).
CREB5	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
CREB5	metacluster_22.29	NFE2 (directAnnotation).
CREB5	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CREB5	metacluster_22.25	NFE2L2 (directAnnotation).
CREB5	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
CREB5	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."