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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CPLX2

Summary for CPLX2

Gene information	Gene symbol	CPLX2
	Ensembl ID	ENSG00000145920
	Entrez ID	10814
	Gene name	complexin 2
	Synonyms	CPX-2\|DKFZp547D155
	Gene type	protein_coding
	UniProtAcc	Q6PUV4

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Dataset with differentially expressed gene: CPLX2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.684208	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.375268	0.00e+00

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Expression of CPLX2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CPLX2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CPLX2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CPLX2	hsa-miR-146a-3p	98.5704	NM_001008220
CPLX2	hsa-miR-4492	97.7902	NM_001008220
CPLX2	hsa-miR-4731-5p	97.7146	NM_001008220
CPLX2	hsa-miR-135b-5p	97.5222	NM_001008220
CPLX2	hsa-miR-135a-5p	97.5222	NM_001008220
CPLX2	hsa-miR-6846-5p	97.1291	NM_001008220
CPLX2	hsa-miR-593-3p	96.5174	NM_001008220
CPLX2	hsa-miR-6848-5p	96.2285	NM_001008220
CPLX2	hsa-miR-7110-3p	95.993	NM_001008220
CPLX2	hsa-miR-4664-5p	95.622	NM_001008220
CPLX2	hsa-miR-4292	95.3315	NM_001008220
CPLX2	hsa-miR-6791-5p	95.3315	NM_001008220
CPLX2	hsa-miR-4447	94.7751	NM_001008220
CPLX2	hsa-miR-762	94.293	NM_001008220
CPLX2	hsa-miR-342-5p	94.192	NM_001008220
CPLX2	hsa-miR-7106-5p	94.1514	NM_001008220
CPLX2	hsa-miR-4505	94.1006	NM_001008220
CPLX2	hsa-miR-4498	93.8006	NM_001008220
CPLX2	hsa-miR-6852-5p	93.7735	NM_001008220
CPLX2	hsa-miR-5001-5p	93.4084	NM_001008220
CPLX2	hsa-miR-1227-5p	93.1791	NM_001008220
CPLX2	hsa-miR-8073	93.1339	NM_001008220
CPLX2	hsa-miR-4651	91.0783	NM_001008220
CPLX2	hsa-miR-5787	90.7471	NM_001008220
CPLX2	hsa-miR-4700-5p	90.5344	NM_001008220
CPLX2	hsa-miR-6730-3p	90.4866	NM_001008220
CPLX2	hsa-miR-221-5p	90.3609	NM_001008220
CPLX2	hsa-miR-637	90.298	NM_001008220
CPLX2	hsa-miR-8089	90.2877	NM_001008220
CPLX2	hsa-miR-4667-5p	90.0173	NM_001008220
CPLX2	hsa-miR-34a-5p	89.9341	NM_001008220
CPLX2	hsa-miR-449a	89.9341	NM_001008220
CPLX2	hsa-miR-3119	89.8515	NM_001008220
CPLX2	hsa-miR-608	88.8457	NM_001008220
CPLX2	hsa-miR-6845-5p	88.0197	NM_001008220
CPLX2	hsa-miR-6762-5p	88.0197	NM_001008220
CPLX2	hsa-miR-642a-3p	87.9532	NM_001008220
CPLX2	hsa-miR-642b-3p	87.9532	NM_001008220
CPLX2	hsa-miR-4472	86.5779	NM_001008220
CPLX2	hsa-miR-8485	86.5469	NM_001008220
CPLX2	hsa-miR-331-3p	85.941	NM_001008220
CPLX2	hsa-miR-6873-3p	84.8766	NM_001008220
CPLX2	hsa-miR-6749-3p	84.4994	NM_001008220
CPLX2	hsa-miR-4691-5p	84.498	NM_001008220
CPLX2	hsa-miR-6798-5p	83.5686	NM_001008220
CPLX2	hsa-miR-185-3p	83.3644	NM_001008220
CPLX2	hsa-miR-34c-5p	82.69	NM_001008220
CPLX2	hsa-miR-449b-5p	82.69	NM_001008220
CPLX2	hsa-miR-6895-3p	82.615	NM_001008220
CPLX2	hsa-miR-7976	81.3453	NM_001008220

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Motifs and transcription factors (TFs) regulating CPLX2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CPLX2	transfac_pro__M02843	BBX (inferredBy_Orthology).
CPLX2	metacluster_135.11	NR2C2 (directAnnotation).
CPLX2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CPLX2	metacluster_7.13	ZFX (directAnnotation).
CPLX2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CPLX2	cisbp__M00968	MTF2 (directAnnotation).
CPLX2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CPLX2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CPLX2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CPLX2	hdpi__ZNF304	ZNF304 (directAnnotation).
CPLX2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CPLX2	transfac_pro__M01199	TRIM28 (directAnnotation).
CPLX2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CPLX2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CPLX2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."