Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CELF2

Summary for CELF2

Gene information	Gene symbol	CELF2
	Ensembl ID	ENSG00000048740
	Entrez ID	10659
	Gene name	CUGBP Elav-like family member 2
	Synonyms	BRUNOL3\|CUGBP2\|Etr-3\|NAPOR-2
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: CELF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.412052	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.479486	2.68e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.561364	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.339853	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.493836	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.537992	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.254597	4.68e-09
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.331958	3.02e-10
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.30124	4.62e-30
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.50038	2.15e-13
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.670614	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.634861	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.353341	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.315502	6.72e-25
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.264586	5.50e-24

Top

Expression of CELF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CELF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CELF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CELF2	hsa-miR-548aq-3p	99.4321	NM_001025077
CELF2	hsa-miR-548ah-3p	99.4321	NM_001025077
CELF2	hsa-miR-548ae-3p	99.4321	NM_001025077
CELF2	hsa-miR-548j-3p	99.4321	NM_001025077
CELF2	hsa-miR-548am-3p	99.4321	NM_001025077
CELF2	hsa-miR-548aj-3p	99.2859	NM_001025077
CELF2	hsa-miR-548x-3p	99.2859	NM_001025077
CELF2	hsa-miR-5688	99.055	NM_001025077
CELF2	hsa-miR-4795-3p	98.8136	NM_001025077
CELF2	hsa-miR-495-3p	98.2234	NM_001025077
CELF2	hsa-miR-3658	95.9271	NM_001025077
CELF2	hsa-miR-1324	95.6981	NM_001025077
CELF2	hsa-miR-4717-3p	95.1651	NM_001025077
CELF2	hsa-miR-4446-5p	94.8378	NM_001025077
CELF2	hsa-miR-5011-5p	94.74	NM_001025076
CELF2	hsa-miR-23c	94.6842	NM_001025077
CELF2	hsa-miR-23b-3p	94.6842	NM_001025077
CELF2	hsa-miR-23a-3p	94.6842	NM_001025077
CELF2	hsa-miR-302e	94.6016	NM_001025077
CELF2	hsa-miR-3163	94.5699	NM_001025076
CELF2	hsa-miR-545-3p	94.4454	NM_001025077
CELF2	hsa-miR-183-5p	94.2542	NM_001025077
CELF2	hsa-miR-9983-3p	93.4842	NM_001025076
CELF2	hsa-miR-7844-5p	92.5324	NM_001025077
CELF2	hsa-miR-126-5p	92.2252	NM_001025077
CELF2	hsa-miR-708-3p	91.8341	NM_001025077
CELF2	hsa-miR-4753-3p	91.6234	NM_001025077
CELF2	hsa-miR-129-5p	90.823	NM_001025076
CELF2	hsa-miR-2682-5p	90.8052	NM_001025077
CELF2	hsa-miR-590-3p	90.4627	NM_001025076
CELF2	hsa-miR-34b-5p	90.3959	NM_001025077
CELF2	hsa-miR-449c-5p	90.3959	NM_001025077
CELF2	hsa-miR-4649-3p	90.2602	NM_001025077
CELF2	hsa-miR-3924	90.0045	NM_001025077
CELF2	hsa-miR-1297	89.9485	NM_001025077
CELF2	hsa-miR-5587-5p	89.7481	NM_001025077
CELF2	hsa-miR-6756-3p	89.5595	NM_001025077
CELF2	hsa-miR-3127-3p	89.5595	NM_001025077
CELF2	hsa-miR-4672	89.2753	NM_001025077
CELF2	hsa-miR-3662	89.109	NM_001025077
CELF2	hsa-miR-4735-5p	89.091	NM_001025077
CELF2	hsa-miR-548p	88.869	NM_001025077
CELF2	hsa-miR-5006-3p	88.552	NM_001025077
CELF2	hsa-miR-4755-5p	88.552	NM_001025077
CELF2	hsa-miR-3120-3p	88.515	NM_001025077
CELF2	hsa-miR-302b-3p	88.4194	NM_001025077
CELF2	hsa-miR-302a-3p	88.4194	NM_001025077
CELF2	hsa-miR-302c-3p	88.4194	NM_001025077
CELF2	hsa-miR-302d-3p	88.4194	NM_001025077
CELF2	hsa-miR-10527-5p	88.2379	NM_001025077

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating CELF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CELF2	metacluster_7.13	ZFX (directAnnotation).
CELF2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CELF2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CELF2	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
CELF2	jaspar__MA1483.2	ELF2 (directAnnotation).
CELF2	metacluster_151.2	ZNF23 (directAnnotation).
CELF2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CELF2	transfac_pro__M05479	ZNF580 (directAnnotation).
CELF2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CELF2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
CELF2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CELF2	hdpi__ETV4	ETV4 (directAnnotation).
CELF2	transfac_pro__M06071	ZNF814 (directAnnotation).
CELF2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CELF2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CELF2	jaspar__MA1933.1	SREBF2 (directAnnotation).
CELF2	jaspar__MA0079.5	SP1 (directAnnotation).
CELF2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CELF2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CELF2	transfac_pro__M07397	ZNF148 (directAnnotation).
CELF2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CELF2	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
CELF2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CELF2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CELF2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CELF2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CELF2	transfac_pro__M01175	ZBTB7B (directAnnotation).
CELF2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CELF2	tfdimers__MD00151	CHURC1 (directAnnotation).
CELF2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CELF2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CELF2	transfac_pro__M01303	SP1 (directAnnotation).
CELF2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CELF2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CELF2	transfac_pro__M02090	E2F4 (directAnnotation).
CELF2	transfac_pro__M01714	KLF15 (directAnnotation).
CELF2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CELF2	jaspar__MA1122.1	TFDP1 (directAnnotation).
CELF2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CELF2	transfac_pro__M02089	E2F3 (directAnnotation).
CELF2	metacluster_3.14	WT1; WT1 (directAnnotation).
CELF2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CELF2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CELF2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CELF2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CELF2	cisbp__M07938	E2F1 (directAnnotation).
CELF2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CELF2	transfac_pro__M07436	WT1 (directAnnotation).
CELF2	transfac_pro__M02281	SP1 (directAnnotation).
CELF2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).

Page: 1 2 3 4 5 6

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."