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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BNIP3

Summary for BNIP3

Gene information	Gene symbol	BNIP3
	Ensembl ID	ENSG00000176171
	Entrez ID	664
	Gene name	BCL2 interacting protein 3
	Synonyms	HABON\|Nip3
	Gene type	protein_coding
	UniProtAcc	Q12983

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Dataset with differentially expressed gene: BNIP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.413693	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.547562	8.55e-25
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.495233	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.557621	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.302365	5.87e-14
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.394454	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.544763	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.282824	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.422135	0.00e+00

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Expression of BNIP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BNIP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BNIP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BNIP3	hsa-miR-4717-5p	96.7937	NM_004052
BNIP3	hsa-miR-411-5p	95.9648	NM_004052
BNIP3	hsa-miR-182-5p	95.9354	NM_004052
BNIP3	hsa-miR-4753-5p	95.2754	NM_004052
BNIP3	hsa-miR-320b	94.3274	NM_004052
BNIP3	hsa-miR-320c	94.3274	NM_004052
BNIP3	hsa-miR-320a-3p	94.3274	NM_004052
BNIP3	hsa-miR-4429	94.3274	NM_004052
BNIP3	hsa-miR-320d	94.3274	NM_004052
BNIP3	hsa-miR-548k	90.7972	NM_004052
BNIP3	hsa-miR-548av-5p	90.7972	NM_004052
BNIP3	hsa-miR-583	90.6652	NM_004052
BNIP3	hsa-miR-145-5p	90.412	NM_004052
BNIP3	hsa-miR-5195-3p	90.412	NM_004052
BNIP3	hsa-miR-3180-5p	89.8587	NM_004052
BNIP3	hsa-miR-559	88.091	NM_004052
BNIP3	hsa-miR-8054	87.6926	NM_004052
BNIP3	hsa-miR-548i	87.6509	NM_004052
BNIP3	hsa-miR-548ab	87.6509	NM_004052
BNIP3	hsa-miR-6885-3p	87.5074	NM_004052
BNIP3	hsa-miR-589-3p	86.9344	NM_004052
BNIP3	hsa-miR-640	86.8847	NM_004052
BNIP3	hsa-miR-922	86.2506	NM_004052
BNIP3	hsa-miR-96-5p	86.0816	NM_004052
BNIP3	hsa-miR-6083	85.4018	NM_004052
BNIP3	hsa-miR-3689e	85.2682	NM_004052
BNIP3	hsa-miR-3689a-5p	85.2682	NM_004052
BNIP3	hsa-miR-3689f	85.2682	NM_004052
BNIP3	hsa-miR-3689b-5p	85.2682	NM_004052
BNIP3	hsa-miR-548w	83.485	NM_004052
BNIP3	hsa-miR-548bb-5p	83.485	NM_004052
BNIP3	hsa-miR-548ak	83.485	NM_004052
BNIP3	hsa-miR-548ay-5p	83.485	NM_004052
BNIP3	hsa-miR-548am-5p	83.485	NM_004052
BNIP3	hsa-miR-548ap-5p	83.485	NM_004052
BNIP3	hsa-miR-548h-5p	83.485	NM_004052
BNIP3	hsa-miR-548au-5p	83.485	NM_004052
BNIP3	hsa-miR-548a-5p	83.485	NM_004052
BNIP3	hsa-miR-548ad-5p	83.485	NM_004052
BNIP3	hsa-miR-548ar-5p	83.485	NM_004052
BNIP3	hsa-miR-548y	83.485	NM_004052
BNIP3	hsa-miR-548l	83.485	NM_004052
BNIP3	hsa-miR-548o-5p	83.485	NM_004052
BNIP3	hsa-miR-548aq-5p	83.485	NM_004052
BNIP3	hsa-miR-548b-5p	83.485	NM_004052
BNIP3	hsa-miR-548c-5p	83.485	NM_004052
BNIP3	hsa-miR-548as-5p	83.485	NM_004052
BNIP3	hsa-miR-548ae-5p	83.485	NM_004052
BNIP3	hsa-miR-548j-5p	83.485	NM_004052
BNIP3	hsa-miR-548d-5p	83.485	NM_004052

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Motifs and transcription factors (TFs) regulating BNIP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BNIP3	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
BNIP3	metacluster_130.15	ARID5B; ARID5B; BPTF (directAnnotation).
BNIP3	transfac_pro__M08187	ABL1 (directAnnotation).
BNIP3	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
BNIP3	swissregulon__hs__FOXD3	FOXD3 (directAnnotation).
BNIP3	tfdimers__MD00456	E2F6; OVOL2 (directAnnotation).
BNIP3	hdpi__RFXANK	RFXANK (directAnnotation).
BNIP3	transfac_public__M00278	GATA1; LDB1; LMO2; TAL1; TCF3 (inferredBy_Orthology).
BNIP3	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
BNIP3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
BNIP3	transfac_pro__M04950	EGR1 (directAnnotation).
BNIP3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
BNIP3	transfac_pro__M00652	NRF1 (directAnnotation).
BNIP3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
BNIP3	transfac_pro__M04866	HDAC2 (directAnnotation).
BNIP3	jaspar__MA1122.1	TFDP1 (directAnnotation).
BNIP3	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
BNIP3	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
BNIP3	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
BNIP3	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
BNIP3	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
BNIP3	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
BNIP3	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
BNIP3	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
BNIP3	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
BNIP3	transfac_pro__M06331	ZNF343 (directAnnotation).
BNIP3	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
BNIP3	transfac_pro__M04918	EGR1 (directAnnotation).
BNIP3	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
BNIP3	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
BNIP3	transfac_public__M00209	NFYA; NFYB; NFYC (directAnnotation).
BNIP3	metacluster_113.3	MYBL1; MYBL1; MYBL2; MYBL2; OVOL1; OVOL2 (directAnnotation). MYB; MYBL1; MYBL1; MYBL1; MYBL1; MYBL2; OVOL1 (inferredBy_Orthology).
BNIP3	hdpi__MLX	MLX (directAnnotation).
BNIP3	taipale_tf_pairs__FOXJ3_ELF1_NNARAAAACCGAAWMN_CAP	ELF1; FOXJ3 (directAnnotation).
BNIP3	homer__TACGTGCV_HIF-1a	HIF1A (directAnnotation).
BNIP3	taipale_tf_pairs__FOXJ2_ELF1_RMAGAAAACCGAANN_CAP_repr	ELF1; FOXJ2 (directAnnotation).
BNIP3	metacluster_22.19	NFE2 (directAnnotation).
BNIP3	metacluster_22.34	BACH2 (directAnnotation).
BNIP3	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
BNIP3	metacluster_22.37	BACH1 (directAnnotation).
BNIP3	tfdimers__MD00269	CRX; PBX1 (directAnnotation).
BNIP3	metacluster_22.13	MAFK (inferredBy_Orthology).
BNIP3	metacluster_22.18	BACH2 (inferredBy_Orthology).
BNIP3	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
BNIP3	metacluster_22.32	NFE2L2 (directAnnotation).
BNIP3	tfdimers__MD00024	FOXO1; PAX4 (directAnnotation).
BNIP3	tfdimers__MD00561	CRX (directAnnotation).
BNIP3	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
BNIP3	transfac_pro__M04748	GABPA (directAnnotation).
BNIP3	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."