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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: BCL7A

Summary for BCL7A

Gene informationGene symbol

BCL7A

Ensembl ID

ENSG00000282873

Entrez ID

605

Gene nameBAF chromatin remodeling complex subunit BCL7A
SynonymsBCL7|SMARCJ1
Gene typeprotein_coding
UniProtAcc

Q4VC05


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Dataset with differentially expressed gene: BCL7A

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE158457

PDX cellsCell lineAcute lymphoblastic leukemiaT-cell acute lymphoblastic leukemia (ALL)Targeted therapydasatinibNAMalignant cells0.2847630.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreB cells-1.159871.41e-05

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells0.5007960.00e+00

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Expression of BCL7A in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to BCL7A

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BCL7A

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
BCL7Ahsa-miR-92a-2-5p98.0082NM_020993
BCL7Ahsa-miR-5582-5p97.5851NM_001024808
BCL7Ahsa-miR-6795-5p97.0937NM_020993
BCL7Ahsa-miR-6887-5p97.0937NM_020993
BCL7Ahsa-miR-444795.7992NM_020993
BCL7Ahsa-miR-329-3p95.303NM_001024808
BCL7Ahsa-miR-362-3p95.303NM_001024808
BCL7Ahsa-miR-21-5p94.3291NM_001024808
BCL7Ahsa-miR-6733-3p93.5616NM_001024808
BCL7Ahsa-miR-676-5p93.2506NM_001024808
BCL7Ahsa-miR-590-5p93.1741NM_001024808
BCL7Ahsa-miR-6516-5p92.9357NM_001024808
BCL7Ahsa-miR-50790.8204NM_001024808
BCL7Ahsa-miR-124-3p90.5218NM_001024808
BCL7Ahsa-miR-506-3p90.5218NM_001024808
BCL7Ahsa-let-7c-3p90.0057NM_001024808
BCL7Ahsa-miR-6769b-5p89.3418NM_020993
BCL7Ahsa-miR-55788.9399NM_001024808
BCL7Ahsa-miR-654-5p88.7712NM_020993
BCL7Ahsa-miR-541-3p88.7712NM_020993
BCL7Ahsa-miR-202-3p88.7257NM_001024808
BCL7Ahsa-miR-447288.3088NM_020993
BCL7Ahsa-miR-4768-3p87.9731NM_020993
BCL7Ahsa-miR-182587.9527NM_001024808
BCL7Ahsa-miR-6730-5p87.2958NM_020993
BCL7Ahsa-miR-391987.2773NM_020993
BCL7Ahsa-miR-6715a-3p86.7086NM_020993
BCL7Ahsa-miR-501-3p86.1125NM_001024808
BCL7Ahsa-miR-502-3p86.1125NM_001024808
BCL7Ahsa-miR-1252-5p85.9542NM_020993
BCL7Ahsa-miR-3065-3p85.9353NM_001024808
BCL7Ahsa-miR-6783-5p85.7155NM_020993
BCL7Ahsa-miR-493-5p85.4842NM_020993
BCL7Ahsa-miR-510-3p85.151NM_020993
BCL7Ahsa-miR-24-3p85.1461NM_001024808
BCL7Ahsa-miR-6748-5p85.0978NM_020993
BCL7Ahsa-miR-7109-5p84.9946NM_020993
BCL7Ahsa-miR-873-5p84.7162NM_020993
BCL7Ahsa-miR-3680-3p84.716NM_001024808
BCL7Ahsa-miR-426984.4952NM_001024808
BCL7Ahsa-miR-6715b-5p84.4952NM_001024808
BCL7Ahsa-miR-3613-3p84.1512NM_020993
BCL7Ahsa-miR-5006-3p84.1195NM_020993
BCL7Ahsa-miR-4755-5p84.1195NM_020993
BCL7Ahsa-miR-203a-3p83.994NM_020993
BCL7Ahsa-miR-15a-5p83.4753NM_001024808
BCL7Ahsa-miR-314882.6726NM_020993
BCL7Ahsa-miR-397682.0852NM_001024808
BCL7Ahsa-miR-6509-5p81.4835NM_020993
BCL7Ahsa-miR-20680.7496NM_001024808
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Motifs and transcription factors (TFs) regulating BCL7A

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
BCL7Akznf__ZNF25_Imbeault2017_OM_MEMEZNF25 (directAnnotation).
BCL7Aswissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
BCL7Ahocomoco__TYY2_HUMAN.H11MO.0.DYY2 (directAnnotation).
BCL7Ametacluster_141.2E2F2; E2F3 (directAnnotation).
BCL7Ahdpi__TP73TP73 (directAnnotation).
BCL7Ataipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_methCDX2 (directAnnotation).
BCL7Ametacluster_165.4CUX1; CUX1; CUX2; CUX2; CUX2; ONECUT1; ONECUT1; ONECUT2; ONECUT2; ONECUT2; ONECUT2; ONECUT3 (directAnnotation). ONECUT1; ONECUT2; ONECUT3 (inferredBy_Orthology).
BCL7Atfdimers__MD00493MYB; NFE2L1 (directAnnotation).
BCL7Atransfac_pro__M04844MAX (directAnnotation).
BCL7Atfdimers__MD00596HOXA13; PPARG (directAnnotation).
BCL7Atransfac_pro__M06388ZNF677 (directAnnotation).
BCL7Atransfac_pro__M06762ZNF222 (directAnnotation).
BCL7Atransfac_pro__M05329KLF16 (inferredBy_Orthology).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."