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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BAZ2A

Summary for BAZ2A

Gene information	Gene symbol	BAZ2A
	Ensembl ID	ENSG00000076108
	Entrez ID	11176
	Gene name	bromodomain adjacent to zinc finger domain 2A
	Synonyms	KIAA0314\|TIP5\|WALp3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: BAZ2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.276311	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.270784	3.99e-06
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.403494	8.17e-16
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.335064	1.38e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.390546	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.343876	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.288528	2.99e-28
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.439358	0.00e+00

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Expression of BAZ2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BAZ2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BAZ2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BAZ2A	hsa-miR-8485	99.9693	NM_001300905
BAZ2A	hsa-miR-7515	99.313	NM_001300905
BAZ2A	hsa-miR-6124	97.7648	NM_001300905
BAZ2A	hsa-miR-4291	97.2691	NM_001300905
BAZ2A	hsa-miR-3619-5p	97.2061	NM_001300905
BAZ2A	hsa-miR-487b-5p	96.9819	NM_001300905
BAZ2A	hsa-miR-487a-5p	96.9819	NM_001300905
BAZ2A	hsa-miR-3163	96.5054	NM_001300905
BAZ2A	hsa-miR-3202	96.2374	NM_001300905
BAZ2A	hsa-miR-214-3p	95.6195	NM_001300905
BAZ2A	hsa-miR-761	95.6195	NM_001300905
BAZ2A	hsa-miR-5196-5p	95.328	NM_001300905
BAZ2A	hsa-miR-4747-5p	95.328	NM_001300905
BAZ2A	hsa-miR-3162-3p	95.2204	NM_001300905
BAZ2A	hsa-miR-4668-5p	94.7527	NM_001300905
BAZ2A	hsa-miR-4731-5p	94.7319	NM_001300905
BAZ2A	hsa-miR-552-5p	93.5366	NM_001300905
BAZ2A	hsa-miR-3150b-3p	93.3316	NM_001300905
BAZ2A	hsa-miR-4784	93.3316	NM_001300905
BAZ2A	hsa-miR-6760-5p	92.1915	NM_001300905
BAZ2A	hsa-miR-6864-5p	92.1202	NM_001300905
BAZ2A	hsa-miR-4649-3p	91.8986	NM_001300905
BAZ2A	hsa-miR-577	91.67	NM_001300905
BAZ2A	hsa-miR-6780b-5p	90.7696	NM_001300905
BAZ2A	hsa-miR-4725-3p	90.7696	NM_001300905
BAZ2A	hsa-miR-372-5p	90.5731	NM_001300905
BAZ2A	hsa-miR-99a-5p	90.3851	NM_001300905
BAZ2A	hsa-miR-99b-5p	90.3851	NM_001300905
BAZ2A	hsa-miR-100-5p	90.3851	NM_001300905
BAZ2A	hsa-miR-6788-5p	89.8017	NM_001300905
BAZ2A	hsa-miR-30c-1-3p	89.8017	NM_001300905
BAZ2A	hsa-miR-30c-2-3p	89.8017	NM_001300905
BAZ2A	hsa-miR-9500	89.3807	NM_001300905
BAZ2A	hsa-miR-922	89.1762	NM_001300905
BAZ2A	hsa-miR-4736	89.0441	NM_001300905
BAZ2A	hsa-miR-7150	88.4801	NM_001300905
BAZ2A	hsa-miR-4689	87.4212	NM_001300905
BAZ2A	hsa-miR-12120	86.9218	NM_001300905
BAZ2A	hsa-miR-6858-5p	86.1932	NM_001300905
BAZ2A	hsa-miR-4271	85.6438	NM_001300905
BAZ2A	hsa-miR-6785-5p	85.3607	NM_001300905
BAZ2A	hsa-miR-4728-5p	85.3607	NM_001300905
BAZ2A	hsa-miR-6510-5p	85.3506	NM_001300905
BAZ2A	hsa-miR-6878-5p	85.1106	NM_001300905
BAZ2A	hsa-miR-125a-3p	84.1451	NM_001300905
BAZ2A	hsa-miR-548e-5p	84.1383	NM_001300905
BAZ2A	hsa-miR-512-5p	83.8373	NM_001300905
BAZ2A	hsa-miR-6828-5p	83.1604	NM_001300905
BAZ2A	hsa-miR-7106-5p	83.0105	NM_001300905
BAZ2A	hsa-miR-6893-3p	82.8593	NM_001300905

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Motifs and transcription factors (TFs) regulating BAZ2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BAZ2A	metacluster_151.2	ZNF23 (directAnnotation).
BAZ2A	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
BAZ2A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
BAZ2A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
BAZ2A	jaspar__MA0079.5	SP1 (directAnnotation).
BAZ2A	metacluster_3.14	WT1; WT1 (directAnnotation).
BAZ2A	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
BAZ2A	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
BAZ2A	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
BAZ2A	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
BAZ2A	metacluster_144.10	ZNF100 (directAnnotation).
BAZ2A	transfac_pro__M04861	SIX5 (directAnnotation).
BAZ2A	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
BAZ2A	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
BAZ2A	hdpi__FLI1	FLI1 (directAnnotation).
BAZ2A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
BAZ2A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
BAZ2A	transfac_pro__M12686	ZBTB10 (directAnnotation).
BAZ2A	metacluster_143.14	ZNF320 (directAnnotation).
BAZ2A	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
BAZ2A	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
BAZ2A	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
BAZ2A	transfac_pro__M04617	ZBTB7A (directAnnotation).
BAZ2A	transfac_pro__M01973	PLAG1 (directAnnotation).
BAZ2A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
BAZ2A	cisbp__M01864	EGR1 (inferredBy_Orthology).
BAZ2A	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
BAZ2A	tfdimers__MD00151	CHURC1 (directAnnotation).
BAZ2A	cisbp__M00139	ZNF281 (inferredBy_Orthology).
BAZ2A	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
BAZ2A	transfac_pro__M01122	ZNF219 (directAnnotation).
BAZ2A	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
BAZ2A	transfac_pro__M00986	CHURC1 (directAnnotation).
BAZ2A	cisbp__M00249	WT1 (directAnnotation).
BAZ2A	transfac_pro__M01714	KLF15 (directAnnotation).
BAZ2A	cisbp__M00135	ZBTB7B (inferredBy_Orthology).
BAZ2A	tfdimers__MD00366	MTF1; OVOL2 (directAnnotation).
BAZ2A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BAZ2A	cisbp__M00341	PAX6 (directAnnotation).
BAZ2A	transfac_pro__M08818	KLF8 (directAnnotation).
BAZ2A	metacluster_135.11	NR2C2 (directAnnotation).
BAZ2A	cisbp__M00968	MTF2 (directAnnotation).
BAZ2A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
BAZ2A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
BAZ2A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
BAZ2A	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
BAZ2A	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
BAZ2A	jaspar__MA1721.1	ZNF93 (directAnnotation).
BAZ2A	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
BAZ2A	metacluster_126.3	LIN28B; LIN28B (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."