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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: B3GNT5

Summary for B3GNT5

Gene information	Gene symbol	B3GNT5
	Ensembl ID	ENSG00000176597
	Entrez ID	84002
	Gene name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
	Synonyms	B3GN-T5\|beta3Gn-T5
	Gene type	protein_coding
	UniProtAcc	Q9BYG0

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Dataset with differentially expressed gene: B3GNT5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.932775	4.55e-02
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.374217	6.57e-24
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.584121	0.00e+00

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Expression of B3GNT5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to B3GNT5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating B3GNT5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
B3GNT5	hsa-miR-548p	99.6779	NM_032047
B3GNT5	hsa-miR-30d-5p	99.6307	NM_032047
B3GNT5	hsa-miR-30a-5p	99.6307	NM_032047
B3GNT5	hsa-miR-30c-5p	99.6307	NM_032047
B3GNT5	hsa-miR-30e-5p	99.6307	NM_032047
B3GNT5	hsa-miR-30b-5p	99.6307	NM_032047
B3GNT5	hsa-miR-1297	99.4076	NM_032047
B3GNT5	hsa-miR-302c-5p	98.8073	NM_032047
B3GNT5	hsa-miR-26a-5p	98.7051	NM_032047
B3GNT5	hsa-miR-26b-5p	98.7051	NM_032047
B3GNT5	hsa-miR-6868-3p	98.6276	NM_032047
B3GNT5	hsa-miR-1248	98.4701	NM_032047
B3GNT5	hsa-miR-203a-3p	98.332	NM_032047
B3GNT5	hsa-miR-4465	97.9969	NM_032047
B3GNT5	hsa-miR-204-5p	97.4546	NM_032047
B3GNT5	hsa-miR-211-5p	97.4546	NM_032047
B3GNT5	hsa-miR-153-5p	96.9525	NM_032047
B3GNT5	hsa-miR-335-3p	96.7648	NM_032047
B3GNT5	hsa-miR-3163	96.7148	NM_032047
B3GNT5	hsa-miR-3143	95.9929	NM_032047
B3GNT5	hsa-miR-576-5p	95.711	NM_032047
B3GNT5	hsa-miR-3686	95.0459	NM_032047
B3GNT5	hsa-miR-579-3p	94.9636	NM_032047
B3GNT5	hsa-miR-664b-3p	94.9636	NM_032047
B3GNT5	hsa-miR-4282	94.5707	NM_032047
B3GNT5	hsa-miR-6867-3p	94.5564	NM_032047
B3GNT5	hsa-miR-548m	94.0947	NM_032047
B3GNT5	hsa-miR-5190	93.8758	NM_032047
B3GNT5	hsa-miR-3688-3p	92.7795	NM_032047
B3GNT5	hsa-miR-627-3p	92.3104	NM_032047
B3GNT5	hsa-miR-548ba	92.1518	NM_032047
B3GNT5	hsa-miR-4755-5p	91.728	NM_032047
B3GNT5	hsa-miR-5006-3p	91.728	NM_032047
B3GNT5	hsa-miR-10527-5p	91.6831	NM_032047
B3GNT5	hsa-miR-4446-5p	91.6409	NM_032047
B3GNT5	hsa-miR-6832-3p	91.404	NM_032047
B3GNT5	hsa-miR-570-5p	90.7982	NM_032047
B3GNT5	hsa-miR-548ai	90.7982	NM_032047
B3GNT5	hsa-miR-548ag	90.7982	NM_032047
B3GNT5	hsa-miR-3663-3p	90.6735	NM_032047
B3GNT5	hsa-miR-29a-3p	90.0068	NM_032047
B3GNT5	hsa-miR-29b-3p	90.0068	NM_032047
B3GNT5	hsa-miR-29c-3p	90.0068	NM_032047
B3GNT5	hsa-miR-3148	88.8245	NM_032047
B3GNT5	hsa-miR-4263	88.6806	NM_032047
B3GNT5	hsa-miR-502-5p	88.4155	NM_032047
B3GNT5	hsa-miR-12135	87.9255	NM_032047
B3GNT5	hsa-miR-944	87.7621	NM_032047
B3GNT5	hsa-miR-10397-5p	87.4431	NM_032047
B3GNT5	hsa-miR-570-3p	86.0684	NM_032047

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Motifs and transcription factors (TFs) regulating B3GNT5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
B3GNT5	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
B3GNT5	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
B3GNT5	transfac_pro__M04617	ZBTB7A (directAnnotation).
B3GNT5	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
B3GNT5	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
B3GNT5	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
B3GNT5	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
B3GNT5	transfac_pro__M07387	ZBTB7A (directAnnotation).
B3GNT5	transfac_pro__M07436	WT1 (directAnnotation).
B3GNT5	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
B3GNT5	transfac_pro__M00716	ZBTB14 (directAnnotation).
B3GNT5	swissregulon__hs__CHD1	CHD1 (directAnnotation).
B3GNT5	hdpi__HIP2	UBE2K (directAnnotation).
B3GNT5	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
B3GNT5	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
B3GNT5	transfac_pro__M04893	TAF1 (directAnnotation).
B3GNT5	transfac_pro__M03876	ZBTB33 (directAnnotation).
B3GNT5	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
B3GNT5	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
B3GNT5	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
B3GNT5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
B3GNT5	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
B3GNT5	metacluster_22.18	BACH2 (inferredBy_Orthology).
B3GNT5	metacluster_22.37	BACH1 (directAnnotation).
B3GNT5	metacluster_22.34	BACH2 (directAnnotation).
B3GNT5	metacluster_22.35	MAFK (directAnnotation).
B3GNT5	metacluster_22.11	NFE2 (directAnnotation).
B3GNT5	cisbp__M01815	CEBPE (inferredBy_Orthology).
B3GNT5	metacluster_22.33	MAFK (inferredBy_Orthology).
B3GNT5	jaspar__MA1125.1	ZNF384 (directAnnotation).
B3GNT5	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
B3GNT5	transfac_pro__M01253	CNOT3 (directAnnotation).
B3GNT5	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
B3GNT5	transfac_pro__M02089	E2F3 (directAnnotation).
B3GNT5	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
B3GNT5	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
B3GNT5	transfac_pro__M04916	TAF1 (directAnnotation).
B3GNT5	metacluster_135.11	NR2C2 (directAnnotation).
B3GNT5	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
B3GNT5	tfdimers__MD00038	TFAP2C (directAnnotation).
B3GNT5	metacluster_7.13	ZFX (directAnnotation).
B3GNT5	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
B3GNT5	cisbp__M00968	MTF2 (directAnnotation).
B3GNT5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
B3GNT5	metacluster_160.20	JUND; PRDM15 (directAnnotation).
B3GNT5	cisbp__M00341	PAX6 (directAnnotation).
B3GNT5	metacluster_198.3	ZFP64 (directAnnotation).
B3GNT5	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
B3GNT5	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
B3GNT5	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."