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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATRX

Summary for ATRX

Gene information	Gene symbol	ATRX
	Ensembl ID	ENSG00000085224
	Entrez ID	546
	Gene name	ATRX chromatin remodeler
	Synonyms	JMS\|MRX52\|RAD54\|XH2\|XNP
	Gene type	protein_coding
	UniProtAcc	P46100

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Dataset with differentially expressed gene: ATRX

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.27689	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.258485	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.276991	1.06e-35
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.320505	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.337084	2.81e-13
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.276611	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.470336	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.585675	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.367145	1.26e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.385932	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.968263	1.51e-02
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.251936	1.30e-14
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.309809	7.23e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.63009	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.487657	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.442238	0.00e+00

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Expression of ATRX in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATRX

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATRX

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATRX	hsa-miR-4690-5p	99.654	NM_000489
ATRX	hsa-miR-5011-5p	99.4943	NM_138270
ATRX	hsa-miR-7159-3p	99.3104	NM_138270
ATRX	hsa-miR-570-3p	98.9098	NM_000489
ATRX	hsa-miR-190a-3p	98.8423	NM_138270
ATRX	hsa-miR-5582-3p	98.5557	NM_138270
ATRX	hsa-miR-5009-3p	98.4105	NM_000489
ATRX	hsa-miR-590-3p	98.4077	NM_000489
ATRX	hsa-miR-3662	98.2895	NM_000489
ATRX	hsa-miR-410-3p	97.8554	NM_000489
ATRX	hsa-miR-4666a-3p	97.5102	NM_000489
ATRX	hsa-miR-628-3p	97.3497	NM_138270
ATRX	hsa-miR-6802-3p	97.295	NM_138270
ATRX	hsa-miR-3658	96.5482	NM_138270
ATRX	hsa-miR-4769-3p	95.5808	NM_000489
ATRX	hsa-miR-6817-5p	95.5808	NM_000489
ATRX	hsa-miR-4775	95.5756	NM_138270
ATRX	hsa-miR-548n	95.5553	NM_000489
ATRX	hsa-miR-205-3p	95.5209	NM_138270
ATRX	hsa-miR-3133	95.0591	NM_000489
ATRX	hsa-miR-1185-2-3p	94.8606	NM_138270
ATRX	hsa-let-7f-2-3p	94.8606	NM_138270
ATRX	hsa-miR-1185-1-3p	94.8606	NM_138270
ATRX	hsa-miR-511-5p	94.2587	NM_138270
ATRX	hsa-miR-4495	94.0627	NM_138270
ATRX	hsa-miR-199a-3p	93.987	NM_000489
ATRX	hsa-miR-199b-3p	93.987	NM_000489
ATRX	hsa-miR-181b-3p	93.1587	NM_000489
ATRX	hsa-miR-4420	93.1587	NM_000489
ATRX	hsa-miR-181b-2-3p	93.1587	NM_000489
ATRX	hsa-miR-4727-5p	93.1276	NM_000489
ATRX	hsa-miR-29a-5p	92.5986	NM_138270
ATRX	hsa-miR-4482-3p	92.5576	NM_138270
ATRX	hsa-miR-548e-3p	92.4205	NM_138270
ATRX	hsa-miR-548az-3p	92.4205	NM_138270
ATRX	hsa-miR-548bc	92.4205	NM_138270
ATRX	hsa-miR-548f-3p	92.4205	NM_138270
ATRX	hsa-miR-145-3p	92.4158	NM_138270
ATRX	hsa-miR-548a-3p	92.4042	NM_138270
ATRX	hsa-miR-3688-3p	92.3812	NM_000489
ATRX	hsa-miR-6738-3p	92.3063	NM_000489
ATRX	hsa-miR-548ar-3p	92.0676	NM_138270
ATRX	hsa-miR-888-5p	91.9835	NM_000489
ATRX	hsa-miR-627-3p	91.7124	NM_138270
ATRX	hsa-miR-100-3p	91.2748	NM_138270
ATRX	hsa-miR-3129-5p	91.2089	NM_000489
ATRX	hsa-miR-92b-3p	91.0711	NM_000489
ATRX	hsa-miR-32-5p	91.0711	NM_000489
ATRX	hsa-miR-92a-3p	91.0711	NM_000489
ATRX	hsa-miR-4704-3p	90.8736	NM_138270

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Motifs and transcription factors (TFs) regulating ATRX

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATRX	cisbp__M02645	ETS1 (directAnnotation).
ATRX	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
ATRX	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
ATRX	cisbp__M00808	MYPOP (inferredBy_Orthology).
ATRX	hdpi__TP73	TP73 (directAnnotation).
ATRX	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ATRX	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ATRX	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ATRX	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ATRX	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ATRX	cisbp__M00788	ZFY (inferredBy_Orthology).
ATRX	hdpi__ZNF304	ZNF304 (directAnnotation).
ATRX	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
ATRX	metacluster_141.2	E2F2; E2F3 (directAnnotation).
ATRX	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ATRX	jaspar__MA0748.2	YY2 (directAnnotation).
ATRX	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
ATRX	metacluster_182.10	ZFX (directAnnotation).
ATRX	transfac_pro__M06833	PEG3 (directAnnotation).
ATRX	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
ATRX	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ATRX	transfac_pro__M04748	GABPA (directAnnotation).
ATRX	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
ATRX	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
ATRX	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
ATRX	transfac_pro__M06032	ZNF727 (directAnnotation).
ATRX	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
ATRX	metacluster_141.4	GLIS2 (directAnnotation).
ATRX	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
ATRX	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
ATRX	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
ATRX	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
ATRX	transfac_pro__M06259	ZNF91 (directAnnotation).
ATRX	metacluster_156.3	DBP; DBP; DBP; DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; TEF; TEF; TEF; TEF; TEF (directAnnotation). DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFILZ; NFILZ; TEF; TEF; TEF; TEF (inferredBy_Orthology).
ATRX	transfac_pro__M06724	ZNF331 (directAnnotation).
ATRX	hdpi__FEZF2	FEZF2 (directAnnotation).
ATRX	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ATRX	hdpi__RARA	RARA (directAnnotation).
ATRX	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ATRX	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ATRX	metacluster_45.4	E2F2 (directAnnotation).
ATRX	transfac_pro__M00430	E2F1 (directAnnotation).
ATRX	hdpi__GTF3C2	GTF3C2 (directAnnotation).
ATRX	jaspar__MA1721.1	ZNF93 (directAnnotation).
ATRX	transfac_pro__M04646	FOXN4 (directAnnotation).
ATRX	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
ATRX	cisbp__M00249	WT1 (directAnnotation).
ATRX	cisbp__M00809	PRDM11 (inferredBy_Orthology).
ATRX	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."