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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARPP19

Summary for ARPP19

Gene information	Gene symbol	ARPP19
	Ensembl ID	ENSG00000128989
	Entrez ID	10776
	Gene name	cAMP regulated phosphoprotein 19
	Synonyms	ARPP-16\|ARPP-19\|ARPP16\|ENSAL
	Gene type	protein_coding
	UniProtAcc	P56211

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Dataset with differentially expressed gene: ARPP19

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.729956	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.318841	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.263851	5.59e-06
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.318918	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.691742	0.00e+00

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Expression of ARPP19 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARPP19

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARPP19

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARPP19	hsa-miR-12136	99.8975	NM_001306191
ARPP19	hsa-miR-524-5p	99.7539	NM_001306191
ARPP19	hsa-miR-520d-5p	99.7539	NM_001306191
ARPP19	hsa-miR-551b-5p	99.6367	NM_001306191
ARPP19	hsa-miR-802	99.6127	NM_001306191
ARPP19	hsa-miR-548aw	98.6041	NM_001306191
ARPP19	hsa-miR-3613-3p	98.5926	NM_001306195
ARPP19	hsa-miR-548c-3p	97.6309	NM_001306191
ARPP19	hsa-miR-5582-3p	97.4962	NM_001306191
ARPP19	hsa-miR-1200	96.2656	NM_001306191
ARPP19	hsa-miR-320b	95.3407	NM_001306191
ARPP19	hsa-miR-320a-3p	95.3407	NM_001306191
ARPP19	hsa-miR-320c	95.3407	NM_001306191
ARPP19	hsa-miR-4429	95.3407	NM_001306191
ARPP19	hsa-miR-320d	95.3407	NM_001306191
ARPP19	hsa-miR-548av-3p	95.2734	NM_001306191
ARPP19	hsa-miR-548f-3p	95.2645	NM_001306191
ARPP19	hsa-miR-1297	95.058	NM_001306191
ARPP19	hsa-miR-548a-3p	94.9822	NM_001306191
ARPP19	hsa-miR-548o-3p	94.8469	NM_001306191
ARPP19	hsa-miR-548ar-3p	94.7714	NM_001306191
ARPP19	hsa-miR-548bc	94.463	NM_001306191
ARPP19	hsa-miR-4803	94.3479	NM_001306191
ARPP19	hsa-miR-29a-3p	94.3173	NM_001306191
ARPP19	hsa-miR-29b-3p	94.3173	NM_001306191
ARPP19	hsa-miR-29c-3p	94.3173	NM_001306191
ARPP19	hsa-miR-1323	94.13	NM_001306191
ARPP19	hsa-miR-548az-3p	94.0509	NM_001306191
ARPP19	hsa-miR-548e-3p	94.0509	NM_001306191
ARPP19	hsa-miR-6882-5p	93.3069	NM_001306191
ARPP19	hsa-miR-4698	93.2509	NM_001306195
ARPP19	hsa-miR-26a-5p	93.1279	NM_001306191
ARPP19	hsa-miR-26b-5p	93.1279	NM_001306191
ARPP19	hsa-miR-10527-5p	92.8907	NM_001306195
ARPP19	hsa-miR-4465	92.8405	NM_001306191
ARPP19	hsa-miR-8063	92.2329	NM_001306195
ARPP19	hsa-miR-4324	92.1368	NM_001306191
ARPP19	hsa-miR-4753-5p	92.0396	NM_001306191
ARPP19	hsa-miR-5197-5p	91.8057	NM_001306191
ARPP19	hsa-miR-4428	91.3188	NM_001306195
ARPP19	hsa-miR-1468-3p	91.3049	NM_001306191
ARPP19	hsa-miR-655-3p	91.3039	NM_001306195
ARPP19	hsa-miR-374c-5p	91.3039	NM_001306195
ARPP19	hsa-miR-1257	90.4294	NM_001306195
ARPP19	hsa-miR-676-5p	90.2253	NM_001306195
ARPP19	hsa-miR-183-5p	90.2192	NM_001306195
ARPP19	hsa-miR-548ao-5p	89.8125	NM_001306195
ARPP19	hsa-miR-548ax	89.8125	NM_001306195
ARPP19	hsa-miR-1304-5p	89.7292	NM_001306191
ARPP19	hsa-miR-5011-5p	89.719	NM_001306191

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Motifs and transcription factors (TFs) regulating ARPP19

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARPP19	jaspar__MA1933.1	SREBF2 (directAnnotation).
ARPP19	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ARPP19	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ARPP19	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
ARPP19	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ARPP19	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ARPP19	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
ARPP19	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ARPP19	metacluster_7.13	ZFX (directAnnotation).
ARPP19	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARPP19	cisbp__M00788	ZFY (inferredBy_Orthology).
ARPP19	metacluster_175.1	ZNF283 (directAnnotation).
ARPP19	transfac_pro__M01199	TRIM28 (directAnnotation).
ARPP19	metacluster_151.2	ZNF23 (directAnnotation).
ARPP19	transfac_pro__M04826	EP300 (directAnnotation).
ARPP19	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
ARPP19	metacluster_81.7	CREB1 (directAnnotation).
ARPP19	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
ARPP19	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."