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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARFIP1

Summary for ARFIP1

Gene information	Gene symbol	ARFIP1
	Ensembl ID	ENSG00000164144
	Entrez ID	27236
	Gene name	ADP ribosylation factor interacting protein 1
	Synonyms	HSU52521
	Gene type	protein_coding
	UniProtAcc	P53367

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Dataset with differentially expressed gene: ARFIP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.349305	2.96e-31

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Expression of ARFIP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARFIP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARFIP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARFIP1	hsa-miR-371b-5p	99.2445	NM_001025595
ARFIP1	hsa-miR-373-5p	99.2445	NM_001025595
ARFIP1	hsa-miR-616-5p	99.2445	NM_001025595
ARFIP1	hsa-miR-4533	98.2356	NM_001025595
ARFIP1	hsa-miR-3163	96.0252	NM_001025593
ARFIP1	hsa-miR-4700-5p	95.931	NM_001025595
ARFIP1	hsa-miR-4667-5p	95.7844	NM_001025595
ARFIP1	hsa-miR-8089	95.7844	NM_001025595
ARFIP1	hsa-miR-5582-5p	95.5909	NM_001025593
ARFIP1	hsa-miR-6792-5p	95.3693	NM_001025593
ARFIP1	hsa-miR-320d	94.2426	NM_001025593
ARFIP1	hsa-miR-320b	94.2426	NM_001025593
ARFIP1	hsa-miR-4429	94.2426	NM_001025593
ARFIP1	hsa-miR-320c	94.2426	NM_001025593
ARFIP1	hsa-miR-320a-3p	94.2426	NM_001025593
ARFIP1	hsa-miR-125b-2-3p	94.0419	NM_001025593
ARFIP1	hsa-miR-876-5p	92.1433	NM_001025593
ARFIP1	hsa-miR-3167	92.0402	NM_001025593
ARFIP1	hsa-miR-4679	91.7345	NM_001025595
ARFIP1	hsa-miR-5584-5p	91.3493	NM_001025595
ARFIP1	hsa-miR-19b-3p	91.028	NM_001025593
ARFIP1	hsa-miR-19a-3p	91.028	NM_001025593
ARFIP1	hsa-miR-6716-5p	90.9809	NM_001025593
ARFIP1	hsa-miR-4697-3p	89.8029	NM_001025593
ARFIP1	hsa-miR-9-3p	89.3347	NM_001025593
ARFIP1	hsa-miR-3692-5p	89.0294	NM_001025595
ARFIP1	hsa-miR-4762-5p	88.6778	NM_001025593
ARFIP1	hsa-miR-3613-3p	87.7272	NM_001025595
ARFIP1	hsa-miR-1305	87.6787	NM_001025593
ARFIP1	hsa-miR-6516-3p	87.2187	NM_001025595
ARFIP1	hsa-miR-148b-3p	87.1264	NM_001025593
ARFIP1	hsa-miR-152-3p	87.1264	NM_001025593
ARFIP1	hsa-miR-148a-3p	87.1264	NM_001025593
ARFIP1	hsa-miR-1468-3p	87.0414	NM_001025593
ARFIP1	hsa-miR-124-3p	86.3796	NM_001025593
ARFIP1	hsa-miR-506-3p	86.3796	NM_001025593
ARFIP1	hsa-miR-541-5p	86.0614	NM_001025593
ARFIP1	hsa-miR-3148	85.8245	NM_001025593
ARFIP1	hsa-miR-3646	85.6425	NM_001025595
ARFIP1	hsa-miR-7155-5p	85.4875	NM_001025595
ARFIP1	hsa-miR-6071	85.4663	NM_001025593
ARFIP1	hsa-miR-637	85.2916	NM_001025595
ARFIP1	hsa-miR-216b-5p	85.1348	NM_001025595
ARFIP1	hsa-miR-548aw	85.0822	NM_001025593
ARFIP1	hsa-miR-6124	82.4964	NM_001025593
ARFIP1	hsa-miR-153-5p	81.8913	NM_001025595
ARFIP1	hsa-miR-302d-5p	81.4772	NM_001025595
ARFIP1	hsa-miR-302b-5p	81.4772	NM_001025595
ARFIP1	hsa-miR-3200-5p	81.4436	NM_001025595
ARFIP1	hsa-miR-6074	81.3739	NM_001025595

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Motifs and transcription factors (TFs) regulating ARFIP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARFIP1	metacluster_135.11	NR2C2 (directAnnotation).
ARFIP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARFIP1	cisbp__M00341	PAX6 (directAnnotation).
ARFIP1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ARFIP1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ARFIP1	metacluster_175.1	ZNF283 (directAnnotation).
ARFIP1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."