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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARFGEF1

Summary for ARFGEF1

Gene information	Gene symbol	ARFGEF1
	Ensembl ID	ENSG00000066777
	Entrez ID	10565
	Gene name	ADP ribosylation factor guanine nucleotide exchange factor 1
	Synonyms	ARFGEP1\|BIG1\|DKFZP434L057\|p200
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ARFGEF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.60094	0.00e+00

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Expression of ARFGEF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARFGEF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARFGEF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARFGEF1	hsa-miR-493-5p	99.9594	NM_006421
ARFGEF1	hsa-let-7g-3p	99.6241	NM_006421
ARFGEF1	hsa-let-7a-2-3p	99.6241	NM_006421
ARFGEF1	hsa-miR-9985	99.5846	NM_006421
ARFGEF1	hsa-miR-27a-3p	99.5846	NM_006421
ARFGEF1	hsa-miR-27b-3p	99.5846	NM_006421
ARFGEF1	hsa-miR-513a-5p	99.5392	NM_006421
ARFGEF1	hsa-miR-33a-3p	98.428	NM_006421
ARFGEF1	hsa-miR-5582-3p	97.4246	NM_006421
ARFGEF1	hsa-miR-3686	96.9633	NM_006421
ARFGEF1	hsa-let-7c-3p	96.725	NM_006421
ARFGEF1	hsa-miR-6883-3p	95.2339	NM_006421
ARFGEF1	hsa-miR-4671-3p	94.9043	NM_006421
ARFGEF1	hsa-miR-376c-3p	94.8031	NM_006421
ARFGEF1	hsa-miR-4668-3p	94.7589	NM_006421
ARFGEF1	hsa-miR-767-3p	94.0398	NM_006421
ARFGEF1	hsa-miR-3115	94.029	NM_006421
ARFGEF1	hsa-miR-4778-5p	93.8371	NM_006421
ARFGEF1	hsa-miR-6501-3p	92.9884	NM_006421
ARFGEF1	hsa-miR-133b	92.1015	NM_006421
ARFGEF1	hsa-miR-133a-3p	92.1015	NM_006421
ARFGEF1	hsa-miR-3613-5p	91.7108	NM_006421
ARFGEF1	hsa-miR-374b-3p	91.5167	NM_006421
ARFGEF1	hsa-miR-6872-3p	91.2621	NM_006421
ARFGEF1	hsa-miR-5584-3p	91.1404	NM_006421
ARFGEF1	hsa-miR-19a-3p	90.8402	NM_006421
ARFGEF1	hsa-miR-19b-3p	90.8402	NM_006421
ARFGEF1	hsa-miR-122b-5p	90.5687	NM_006421
ARFGEF1	hsa-miR-4473	90.5686	NM_006421
ARFGEF1	hsa-miR-4446-5p	90.2119	NM_006421
ARFGEF1	hsa-miR-6507-3p	89.5139	NM_006421
ARFGEF1	hsa-miR-574-5p	88.6084	NM_006421
ARFGEF1	hsa-miR-1297	88.3077	NM_006421
ARFGEF1	hsa-miR-382-5p	88.1677	NM_006421
ARFGEF1	hsa-miR-4307	87.7844	NM_006421
ARFGEF1	hsa-miR-648	86.5453	NM_006421
ARFGEF1	hsa-miR-548c-3p	85.1307	NM_006421
ARFGEF1	hsa-miR-26a-5p	84.9647	NM_006421
ARFGEF1	hsa-miR-26b-5p	84.9647	NM_006421
ARFGEF1	hsa-miR-3133	84.5458	NM_006421
ARFGEF1	hsa-miR-9-5p	84.2651	NM_006421
ARFGEF1	hsa-miR-6074	83.5407	NM_006421
ARFGEF1	hsa-miR-548x-3p	82.9003	NM_006421
ARFGEF1	hsa-miR-548aj-3p	82.9003	NM_006421
ARFGEF1	hsa-miR-649	82.7063	NM_006421
ARFGEF1	hsa-miR-490-3p	82.7063	NM_006421
ARFGEF1	hsa-miR-122-5p	82.2686	NM_006421
ARFGEF1	hsa-miR-1277-5p	82.121	NM_006421
ARFGEF1	hsa-miR-5008-5p	82.0055	NM_006421
ARFGEF1	hsa-miR-192-5p	81.9697	NM_006421

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Motifs and transcription factors (TFs) regulating ARFGEF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARFGEF1	metacluster_135.11	NR2C2 (directAnnotation).
ARFGEF1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARFGEF1	tfdimers__MD00038	TFAP2C (directAnnotation).
ARFGEF1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ARFGEF1	metacluster_7.13	ZFX (directAnnotation).
ARFGEF1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ARFGEF1	cisbp__M00968	MTF2 (directAnnotation).
ARFGEF1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ARFGEF1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ARFGEF1	cisbp__M00341	PAX6 (directAnnotation).
ARFGEF1	metacluster_198.3	ZFP64 (directAnnotation).
ARFGEF1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARFGEF1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ARFGEF1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ARFGEF1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ARFGEF1	cisbp__M00788	ZFY (inferredBy_Orthology).
ARFGEF1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ARFGEF1	metacluster_175.1	ZNF283 (directAnnotation).
ARFGEF1	hdpi__ZNF304	ZNF304 (directAnnotation).
ARFGEF1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ARFGEF1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ARFGEF1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ARFGEF1	transfac_pro__M01199	TRIM28 (directAnnotation).
ARFGEF1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ARFGEF1	metacluster_151.2	ZNF23 (directAnnotation).
ARFGEF1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARFGEF1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARFGEF1	transfac_pro__M03806	ZBTB7C (directAnnotation).
ARFGEF1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."