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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: APPL1

Summary for APPL1

Gene information	Gene symbol	APPL1
	Ensembl ID	ENSG00000157500
	Entrez ID	26060
	Gene name	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
	Synonyms	APPL
	Gene type	protein_coding
	UniProtAcc	Q9UKG1

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Dataset with differentially expressed gene: APPL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.458191	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.29223	9.42e-39
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.27707	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.254404	1.62e-07
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.289134	1.86e-26
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.535485	0.00e+00

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Expression of APPL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to APPL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating APPL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
APPL1	hsa-miR-323a-3p	98.9723	NM_012096
APPL1	hsa-miR-944	97.3948	NM_012096
APPL1	hsa-miR-5094	96.5648	NM_012096
APPL1	hsa-miR-4803	96.3556	NM_012096
APPL1	hsa-miR-513a-3p	96.299	NM_012096
APPL1	hsa-miR-513c-3p	96.299	NM_012096
APPL1	hsa-miR-548n	96.281	NM_012096
APPL1	hsa-miR-548t-5p	95.811	NM_012096
APPL1	hsa-miR-548az-5p	95.811	NM_012096
APPL1	hsa-miR-548l	95.7841	NM_012096
APPL1	hsa-miR-4324	95.2284	NM_012096
APPL1	hsa-miR-12136	95.186	NM_012096
APPL1	hsa-miR-3606-3p	94.7885	NM_012096
APPL1	hsa-miR-7153-5p	94.5954	NM_012096
APPL1	hsa-miR-367-3p	94.4604	NM_012096
APPL1	hsa-miR-25-3p	94.4604	NM_012096
APPL1	hsa-miR-363-3p	94.4604	NM_012096
APPL1	hsa-miR-3646	94.1426	NM_012096
APPL1	hsa-miR-96-5p	94.0902	NM_012096
APPL1	hsa-miR-3680-3p	94.0504	NM_012096
APPL1	hsa-miR-1226-3p	94.0471	NM_012096
APPL1	hsa-miR-92b-3p	94.0043	NM_012096
APPL1	hsa-miR-32-5p	94.0043	NM_012096
APPL1	hsa-miR-92a-3p	94.0043	NM_012096
APPL1	hsa-miR-12133	93.8024	NM_012096
APPL1	hsa-miR-4698	93.4132	NM_012096
APPL1	hsa-miR-1271-5p	93.2376	NM_012096
APPL1	hsa-miR-146b-5p	93.1724	NM_012096
APPL1	hsa-miR-146a-5p	93.1724	NM_012096
APPL1	hsa-miR-3529-3p	92.9724	NM_012096
APPL1	hsa-miR-548c-3p	92.8743	NM_012096
APPL1	hsa-miR-4762-5p	92.809	NM_012096
APPL1	hsa-miR-490-5p	92.4392	NM_012096
APPL1	hsa-miR-4310	92.0512	NM_012096
APPL1	hsa-miR-616-5p	92.0311	NM_012096
APPL1	hsa-miR-373-5p	92.0311	NM_012096
APPL1	hsa-miR-371b-5p	92.0311	NM_012096
APPL1	hsa-miR-182-5p	91.8266	NM_012096
APPL1	hsa-miR-5011-5p	91.76	NM_012096
APPL1	hsa-miR-633	91.5757	NM_012096
APPL1	hsa-miR-494-3p	91.186	NM_012096
APPL1	hsa-miR-622	91.1306	NM_012096
APPL1	hsa-miR-576-5p	90.9538	NM_012096
APPL1	hsa-miR-3650	90.9129	NM_012096
APPL1	hsa-miR-4482-3p	90.7567	NM_012096
APPL1	hsa-miR-335-3p	90.5168	NM_012096
APPL1	hsa-miR-5589-3p	90.4932	NM_012096
APPL1	hsa-miR-2053	90.1675	NM_012096
APPL1	hsa-miR-1184	89.4548	NM_012096
APPL1	hsa-miR-4671-3p	89.4334	NM_012096

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Motifs and transcription factors (TFs) regulating APPL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
APPL1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
APPL1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
APPL1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
APPL1	transfac_pro__M04950	EGR1 (directAnnotation).
APPL1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
APPL1	transfac_pro__M04826	EP300 (directAnnotation).
APPL1	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
APPL1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
APPL1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
APPL1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
APPL1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
APPL1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
APPL1	transfac_pro__M00652	NRF1 (directAnnotation).
APPL1	hdpi__ETV4	ETV4 (directAnnotation).
APPL1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
APPL1	transfac_pro__M04866	HDAC2 (directAnnotation).
APPL1	jaspar__MA1122.1	TFDP1 (directAnnotation).
APPL1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
APPL1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
APPL1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
APPL1	metacluster_135.11	NR2C2 (directAnnotation).
APPL1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
APPL1	tfdimers__MD00038	TFAP2C (directAnnotation).
APPL1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
APPL1	metacluster_7.13	ZFX (directAnnotation).
APPL1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
APPL1	cisbp__M00968	MTF2 (directAnnotation).
APPL1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
APPL1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
APPL1	cisbp__M00341	PAX6 (directAnnotation).
APPL1	metacluster_198.3	ZFP64 (directAnnotation).
APPL1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
APPL1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
APPL1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
APPL1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
APPL1	cisbp__M00788	ZFY (inferredBy_Orthology).
APPL1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
APPL1	metacluster_175.1	ZNF283 (directAnnotation).
APPL1	hdpi__ZNF304	ZNF304 (directAnnotation).
APPL1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
APPL1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
APPL1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
APPL1	transfac_pro__M01199	TRIM28 (directAnnotation).
APPL1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
APPL1	metacluster_151.2	ZNF23 (directAnnotation).
APPL1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
APPL1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
APPL1	transfac_pro__M03806	ZBTB7C (directAnnotation).
APPL1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
APPL1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."