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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: APPBP2

Summary for APPBP2

Gene information	Gene symbol	APPBP2
	Ensembl ID	ENSG00000062725
	Entrez ID	10513
	Gene name	amyloid beta precursor protein binding protein 2
	Synonyms	Hs.84084\|KIAA0228\|PAT1
	Gene type	protein_coding
	UniProtAcc	Q92624

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Dataset with differentially expressed gene: APPBP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.353627	1.48e-38

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Expression of APPBP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to APPBP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating APPBP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
APPBP2	hsa-miR-7152-3p	99.9699	NM_001282476
APPBP2	hsa-miR-196a-1-3p	98.9898	NM_006380
APPBP2	hsa-miR-12136	98.5969	NM_001282476
APPBP2	hsa-miR-548n	98.4443	NM_006380
APPBP2	hsa-miR-520d-5p	98.3211	NM_001282476
APPBP2	hsa-miR-524-5p	98.3211	NM_001282476
APPBP2	hsa-miR-548x-3p	98.0753	NM_001282476
APPBP2	hsa-miR-548aj-3p	98.0753	NM_001282476
APPBP2	hsa-miR-4282	97.9053	NM_001282476
APPBP2	hsa-miR-548ae-3p	97.8384	NM_001282476
APPBP2	hsa-miR-548aq-3p	97.8384	NM_001282476
APPBP2	hsa-miR-548am-3p	97.8384	NM_001282476
APPBP2	hsa-miR-548ah-3p	97.8384	NM_001282476
APPBP2	hsa-miR-548j-3p	97.8384	NM_001282476
APPBP2	hsa-miR-548l	97.1837	NM_006380
APPBP2	hsa-miR-217-5p	96.5985	NM_001282476
APPBP2	hsa-miR-3646	96.5055	NM_001282476
APPBP2	hsa-miR-3606-5p	95.9824	NM_001282476
APPBP2	hsa-miR-6807-3p	95.7368	NM_001282476
APPBP2	hsa-miR-891a-3p	95.5478	NM_001282476
APPBP2	hsa-miR-6131	94.6627	NM_001282476
APPBP2	hsa-miR-4766-3p	94.3672	NM_006380
APPBP2	hsa-miR-2276-3p	94.1593	NM_001282476
APPBP2	hsa-miR-9985	93.9994	NM_001282476
APPBP2	hsa-miR-27a-3p	93.9994	NM_001282476
APPBP2	hsa-miR-27b-3p	93.9994	NM_001282476
APPBP2	hsa-miR-1200	93.1292	NM_001282476
APPBP2	hsa-miR-4703-5p	92.0399	NM_006380
APPBP2	hsa-miR-144-3p	91.8389	NM_001282476
APPBP2	hsa-miR-548m	91.1041	NM_006380
APPBP2	hsa-miR-3065-5p	91.0689	NM_006380
APPBP2	hsa-miR-3942-5p	90.4082	NM_006380
APPBP2	hsa-miR-4324	90.292	NM_001282476
APPBP2	hsa-miR-544a	90.1967	NM_006380
APPBP2	hsa-miR-559	89.9178	NM_006380
APPBP2	hsa-miR-548k	89.7392	NM_006380
APPBP2	hsa-miR-548ab	89.7392	NM_006380
APPBP2	hsa-miR-548av-5p	89.7392	NM_006380
APPBP2	hsa-miR-548i	89.7392	NM_006380
APPBP2	hsa-miR-5680	89.7287	NM_001282476
APPBP2	hsa-miR-4760-3p	89.5851	NM_006380
APPBP2	hsa-miR-1468-3p	89.5489	NM_001282476
APPBP2	hsa-miR-3163	89.5227	NM_001282476
APPBP2	hsa-miR-190b-3p	89.5086	NM_001282476
APPBP2	hsa-miR-3529-3p	89.4494	NM_006380
APPBP2	hsa-miR-4497	89.4307	NM_001282476
APPBP2	hsa-miR-142-5p	89.2047	NM_001282476
APPBP2	hsa-miR-5590-3p	89.2047	NM_001282476
APPBP2	hsa-miR-7153-3p	88.8197	NM_001282476
APPBP2	hsa-miR-3688-5p	88.4744	NM_001282476

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Motifs and transcription factors (TFs) regulating APPBP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
APPBP2	metacluster_135.11	NR2C2 (directAnnotation).
APPBP2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
APPBP2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
APPBP2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
APPBP2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."