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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKRD44

Summary for ANKRD44

Gene information	Gene symbol	ANKRD44
	Ensembl ID	ENSG00000065413
	Entrez ID	91526
	Gene name	ankyrin repeat domain 44
	Synonyms	PP6-ARS-B
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ANKRD44

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.296624	5.40e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.387268	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.420157	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.449946	3.19e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.357691	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.425377	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.347615	9.93e-16
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.451868	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.521772	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.443419	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.31662	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.280867	2.23e-14

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Expression of ANKRD44 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKRD44

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKRD44

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKRD44	hsa-miR-524-5p	99.2242	NM_001195144
ANKRD44	hsa-miR-520d-5p	99.2242	NM_001195144
ANKRD44	hsa-miR-579-3p	98.2336	NM_001195144
ANKRD44	hsa-miR-3163	98.1825	NM_001195144
ANKRD44	hsa-miR-1468-3p	98.0348	NM_001195144
ANKRD44	hsa-miR-664b-3p	97.8174	NM_001195144
ANKRD44	hsa-miR-8485	97.3286	NM_001195144
ANKRD44	hsa-miR-141-3p	97.0118	NM_001195144
ANKRD44	hsa-miR-200a-3p	97.0118	NM_001195144
ANKRD44	hsa-miR-1250-3p	96.9813	NM_001195144
ANKRD44	hsa-miR-4262	96.3236	NM_001195144
ANKRD44	hsa-miR-5696	96.2934	NM_001195144
ANKRD44	hsa-miR-137-3p	96.2752	NM_001195144
ANKRD44	hsa-miR-636	96.2156	NM_001195144
ANKRD44	hsa-miR-607	95.8091	NM_001195144
ANKRD44	hsa-miR-6504-3p	95.4071	NM_001195144
ANKRD44	hsa-miR-10399-5p	95.4071	NM_001195144
ANKRD44	hsa-miR-181b-5p	95.0217	NM_001195144
ANKRD44	hsa-miR-181c-5p	95.0217	NM_001195144
ANKRD44	hsa-miR-181a-5p	95.0217	NM_001195144
ANKRD44	hsa-miR-181d-5p	95.0217	NM_001195144
ANKRD44	hsa-miR-582-5p	94.797	NM_001195144
ANKRD44	hsa-miR-3671	94.788	NM_001195144
ANKRD44	hsa-miR-4764-3p	94.0736	NM_001195144
ANKRD44	hsa-miR-5589-3p	94.0493	NM_001195144
ANKRD44	hsa-miR-570-3p	93.5113	NM_001195144
ANKRD44	hsa-miR-4282	93.5052	NM_153697
ANKRD44	hsa-miR-548g-5p	93.3734	NM_001195144
ANKRD44	hsa-miR-548x-5p	93.3734	NM_001195144
ANKRD44	hsa-miR-548f-5p	93.3734	NM_001195144
ANKRD44	hsa-miR-548aj-5p	93.3734	NM_001195144
ANKRD44	hsa-miR-4703-3p	93.2813	NM_001195144
ANKRD44	hsa-miR-620	93.1043	NM_001195144
ANKRD44	hsa-miR-1270	93.1043	NM_001195144
ANKRD44	hsa-miR-24-3p	93.0806	NM_153697
ANKRD44	hsa-miR-935	92.7631	NM_001195144
ANKRD44	hsa-miR-490-3p	92.5381	NM_153697
ANKRD44	hsa-miR-338-5p	92.533	NM_001195144
ANKRD44	hsa-miR-10522-5p	92.4132	NM_153697
ANKRD44	hsa-miR-6508-5p	92.1168	NM_001195144
ANKRD44	hsa-miR-1279	92.0047	NM_001195144
ANKRD44	hsa-miR-5011-5p	91.9543	NM_001195144
ANKRD44	hsa-miR-141-5p	91.9534	NM_001195144
ANKRD44	hsa-miR-12131	91.934	NM_001195144
ANKRD44	hsa-miR-3148	91.8176	NM_001195144
ANKRD44	hsa-let-7a-3p	91.7406	NM_001195144
ANKRD44	hsa-miR-98-3p	91.7406	NM_001195144
ANKRD44	hsa-let-7b-3p	91.7406	NM_001195144
ANKRD44	hsa-let-7f-1-3p	91.7406	NM_001195144
ANKRD44	hsa-miR-32-5p	91.5411	NM_001195144

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Motifs and transcription factors (TFs) regulating ANKRD44

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKRD44	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
ANKRD44	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
ANKRD44	transfac_pro__M05708	ZNF136 (directAnnotation).
ANKRD44	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
ANKRD44	transfac_pro__M06259	ZNF91 (directAnnotation).
ANKRD44	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ANKRD44	transfac_pro__M05380	NR2E1 (inferredBy_Orthology).
ANKRD44	hdpi__NRL	NRL (directAnnotation).
ANKRD44	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ANKRD44	cisbp__M00968	MTF2 (directAnnotation).
ANKRD44	hdpi__FEZF2	FEZF2 (directAnnotation).
ANKRD44	transfac_pro__M07310	SP5 (directAnnotation).
ANKRD44	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ANKRD44	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ANKRD44	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ANKRD44	metacluster_155.11	SPZ1 (directAnnotation).
ANKRD44	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ANKRD44	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ANKRD44	hdpi__HTATIP2	HTATIP2 (directAnnotation).
ANKRD44	hdpi__HIP2	UBE2K (directAnnotation).
ANKRD44	hdpi__ZNF304	ZNF304 (directAnnotation).
ANKRD44	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
ANKRD44	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ANKRD44	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ANKRD44	transfac_pro__M02089	E2F3 (directAnnotation).
ANKRD44	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ANKRD44	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ANKRD44	cisbp__M07938	E2F1 (directAnnotation).
ANKRD44	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
ANKRD44	transfac_pro__M04817	ZBTB33 (directAnnotation).
ANKRD44	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ANKRD44	tfdimers__MD00483	ZBTB14 (directAnnotation).
ANKRD44	transfac_pro__M07317	CTBP1 (directAnnotation).
ANKRD44	transfac_pro__M12697	ZNF142 (directAnnotation).
ANKRD44	transfac_pro__M00716	ZBTB14 (directAnnotation).
ANKRD44	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ANKRD44	transfac_pro__M03806	ZBTB7C (directAnnotation).
ANKRD44	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ANKRD44	transfac_pro__M04893	TAF1 (directAnnotation).
ANKRD44	transfac_pro__M01253	CNOT3 (directAnnotation).
ANKRD44	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ANKRD44	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ANKRD44	transfac_pro__M01783	SP2 (directAnnotation).
ANKRD44	transfac_pro__M04916	TAF1 (directAnnotation).
ANKRD44	hdpi__RARA	RARA (directAnnotation).
ANKRD44	jaspar__MA1650.1	ZBTB14 (directAnnotation).
ANKRD44	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ANKRD44	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ANKRD44	cisbp__M08228	PAX5 (directAnnotation).
ANKRD44	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."