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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKRD17

Summary for ANKRD17

Gene information	Gene symbol	ANKRD17
	Ensembl ID	ENSG00000132466
	Entrez ID	26057
	Gene name	ankyrin repeat domain 17
	Synonyms	FLJ22206\|GTAR\|KIAA0697\|MASK2\|NY-BR-16
	Gene type	protein_coding
	UniProtAcc	O75179

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Dataset with differentially expressed gene: ANKRD17

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.299778	1.86e-17
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.480828	1.02e-37

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Expression of ANKRD17 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKRD17

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKRD17

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKRD17	hsa-miR-3163	99.4094	NM_001286771
ANKRD17	hsa-miR-570-5p	98.6905	NM_001286771
ANKRD17	hsa-miR-548ai	98.6905	NM_001286771
ANKRD17	hsa-miR-548ag	98.6905	NM_001286771
ANKRD17	hsa-miR-548ba	98.6905	NM_001286771
ANKRD17	hsa-miR-590-3p	97.6826	NM_198889
ANKRD17	hsa-miR-4775	97.4647	NM_198889
ANKRD17	hsa-miR-936	96.1638	NM_198889
ANKRD17	hsa-miR-4659a-3p	95.9306	NM_001286771
ANKRD17	hsa-miR-4659b-3p	95.9306	NM_001286771
ANKRD17	hsa-miR-30d-5p	95.0689	NM_001286771
ANKRD17	hsa-miR-30b-5p	95.0689	NM_001286771
ANKRD17	hsa-miR-30c-5p	95.0689	NM_001286771
ANKRD17	hsa-miR-30e-5p	95.0689	NM_001286771
ANKRD17	hsa-miR-30a-5p	95.0689	NM_001286771
ANKRD17	hsa-miR-548m	94.6742	NM_001286771
ANKRD17	hsa-miR-892c-3p	94.4666	NM_001286771
ANKRD17	hsa-miR-633	94.0613	NM_198889
ANKRD17	hsa-miR-365b-3p	94.0458	NM_001286771
ANKRD17	hsa-miR-365a-3p	94.0458	NM_001286771
ANKRD17	hsa-miR-4495	94.0201	NM_001286771
ANKRD17	hsa-miR-4652-3p	93.9347	NM_198889
ANKRD17	hsa-miR-4460	93.9147	NM_001286771
ANKRD17	hsa-miR-106b-5p	93.6904	NM_001286771
ANKRD17	hsa-miR-20a-5p	93.6904	NM_001286771
ANKRD17	hsa-miR-548t-3p	93.6795	NM_001286771
ANKRD17	hsa-miR-548aa	93.6795	NM_001286771
ANKRD17	hsa-miR-548ap-3p	93.6795	NM_001286771
ANKRD17	hsa-miR-421	93.0251	NM_198889
ANKRD17	hsa-miR-1285-5p	92.9608	NM_198889
ANKRD17	hsa-miR-4676-3p	92.8021	NM_001286771
ANKRD17	hsa-miR-452-5p	92.8021	NM_001286771
ANKRD17	hsa-miR-6832-3p	92.7061	NM_198889
ANKRD17	hsa-miR-370-5p	92.5017	NM_001286771
ANKRD17	hsa-miR-526b-3p	92.3396	NM_001286771
ANKRD17	hsa-miR-3671	92.3368	NM_001286771
ANKRD17	hsa-miR-887-5p	92.2359	NM_001286771
ANKRD17	hsa-miR-222-5p	92.2254	NM_198889
ANKRD17	hsa-miR-6739-5p	92.2031	NM_198889
ANKRD17	hsa-miR-93-5p	91.9326	NM_001286771
ANKRD17	hsa-miR-17-5p	91.9326	NM_001286771
ANKRD17	hsa-miR-20b-5p	91.9326	NM_001286771
ANKRD17	hsa-miR-519d-3p	91.9326	NM_001286771
ANKRD17	hsa-miR-106a-5p	91.9326	NM_001286771
ANKRD17	hsa-miR-371b-5p	91.885	NM_001286771
ANKRD17	hsa-miR-616-5p	91.885	NM_001286771
ANKRD17	hsa-miR-373-5p	91.885	NM_001286771
ANKRD17	hsa-miR-302d-3p	91.4376	NM_001286771
ANKRD17	hsa-miR-302a-3p	91.4376	NM_001286771
ANKRD17	hsa-miR-520e-3p	91.4376	NM_001286771

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Motifs and transcription factors (TFs) regulating ANKRD17

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKRD17	metacluster_135.11	NR2C2 (directAnnotation).
ANKRD17	tfdimers__MD00038	TFAP2C (directAnnotation).
ANKRD17	cisbp__M00968	MTF2 (directAnnotation).
ANKRD17	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ANKRD17	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ANKRD17	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ANKRD17	cisbp__M00788	ZFY (inferredBy_Orthology).
ANKRD17	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ANKRD17	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ANKRD17	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ANKRD17	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ANKRD17	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ANKRD17	transfac_pro__M03806	ZBTB7C (directAnnotation).
ANKRD17	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ANKRD17	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
ANKRD17	hdpi__TP73	TP73 (directAnnotation).
ANKRD17	transfac_pro__M05976	ZNF223 (directAnnotation).
ANKRD17	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
ANKRD17	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."