Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AKIRIN1

Summary for AKIRIN1

Gene information	Gene symbol	AKIRIN1
	Ensembl ID	ENSG00000174574
	Entrez ID	79647
	Gene name	akirin 1
	Synonyms	C1orf108\|FLJ12666
	Gene type	protein_coding
	UniProtAcc	Q9H9L7

Top

Dataset with differentially expressed gene: AKIRIN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.271505	9.89e-36
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.474134	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.505316	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.401607	3.78e-34

Top

Expression of AKIRIN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to AKIRIN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating AKIRIN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AKIRIN1	hsa-miR-9985	99.4125	NM_024595
AKIRIN1	hsa-miR-27b-3p	99.4125	NM_024595
AKIRIN1	hsa-miR-27a-3p	99.4125	NM_024595
AKIRIN1	hsa-miR-524-5p	98.3113	NM_001136275
AKIRIN1	hsa-miR-520d-5p	98.3113	NM_001136275
AKIRIN1	hsa-miR-4261	97.6978	NM_024595
AKIRIN1	hsa-miR-183-3p	96.9769	NM_024595
AKIRIN1	hsa-miR-147b-5p	96.9507	NM_024595
AKIRIN1	hsa-miR-4684-3p	96.3361	NM_024595
AKIRIN1	hsa-miR-128-3p	95.9965	NM_024595
AKIRIN1	hsa-miR-216a-3p	95.9965	NM_024595
AKIRIN1	hsa-miR-3973	95.801	NM_024595
AKIRIN1	hsa-miR-181c-5p	94.9777	NM_001136275
AKIRIN1	hsa-miR-181a-5p	94.9777	NM_001136275
AKIRIN1	hsa-miR-181b-5p	94.9777	NM_001136275
AKIRIN1	hsa-miR-181d-5p	94.9777	NM_001136275
AKIRIN1	hsa-miR-4789-3p	94.9708	NM_024595
AKIRIN1	hsa-miR-3681-3p	94.9028	NM_024595
AKIRIN1	hsa-miR-4468	94.7338	NM_024595
AKIRIN1	hsa-miR-6830-3p	93.1495	NM_001136275
AKIRIN1	hsa-let-7c-3p	92.5606	NM_001136275
AKIRIN1	hsa-miR-4309	92.481	NM_001136275
AKIRIN1	hsa-miR-3198	92.481	NM_001136275
AKIRIN1	hsa-miR-4262	92.248	NM_001136275
AKIRIN1	hsa-miR-1912-3p	92.1265	NM_001136275
AKIRIN1	hsa-miR-1295b-5p	90.9543	NM_001136275
AKIRIN1	hsa-miR-545-5p	90.5789	NM_024595
AKIRIN1	hsa-miR-3688-5p	88.9826	NM_001136275
AKIRIN1	hsa-miR-4252	88.868	NM_001136275
AKIRIN1	hsa-miR-548aw	88.0052	NM_024595
AKIRIN1	hsa-miR-944	87.9881	NM_001136275
AKIRIN1	hsa-miR-6882-5p	87.9418	NM_024595
AKIRIN1	hsa-miR-6818-5p	87.7025	NM_024595
AKIRIN1	hsa-miR-186-5p	87.6987	NM_024595
AKIRIN1	hsa-miR-593-3p	87.2879	NM_024595
AKIRIN1	hsa-miR-9902	87.0691	NM_024595
AKIRIN1	hsa-miR-507	86.8945	NM_024595
AKIRIN1	hsa-miR-409-3p	86.3394	NM_024595
AKIRIN1	hsa-miR-5587-5p	86.3348	NM_001136275
AKIRIN1	hsa-miR-557	86.2931	NM_024595
AKIRIN1	hsa-miR-5193	86.2368	NM_024595
AKIRIN1	hsa-miR-1257	86.2301	NM_001136275
AKIRIN1	hsa-miR-3910	86.0864	NM_024595
AKIRIN1	hsa-miR-6889-3p	85.8712	NM_001136275
AKIRIN1	hsa-miR-6715a-3p	85.5267	NM_024595
AKIRIN1	hsa-miR-12122	85.3567	NM_024595
AKIRIN1	hsa-miR-7854-3p	84.8872	NM_001136275
AKIRIN1	hsa-miR-568	84.3323	NM_024595
AKIRIN1	hsa-miR-6074	83.9357	NM_024595
AKIRIN1	hsa-miR-1255a	83.7755	NM_024595

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating AKIRIN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AKIRIN1	metacluster_7.13	ZFX (directAnnotation).
AKIRIN1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
AKIRIN1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
AKIRIN1	metacluster_151.2	ZNF23 (directAnnotation).
AKIRIN1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
AKIRIN1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
AKIRIN1	hdpi__ETV4	ETV4 (directAnnotation).
AKIRIN1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
AKIRIN1	jaspar__MA0079.5	SP1 (directAnnotation).
AKIRIN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
AKIRIN1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
AKIRIN1	metacluster_198.3	ZFP64 (directAnnotation).
AKIRIN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
AKIRIN1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
AKIRIN1	cisbp__M00788	ZFY (inferredBy_Orthology).
AKIRIN1	metacluster_175.1	ZNF283 (directAnnotation).
AKIRIN1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
AKIRIN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
AKIRIN1	transfac_pro__M03806	ZBTB7C (directAnnotation).
AKIRIN1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
AKIRIN1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
AKIRIN1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
AKIRIN1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
AKIRIN1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
AKIRIN1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
AKIRIN1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
AKIRIN1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
AKIRIN1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
AKIRIN1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
AKIRIN1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
AKIRIN1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
AKIRIN1	transfac_pro__M01973	PLAG1 (directAnnotation).
AKIRIN1	transfac_pro__M01303	SP1 (directAnnotation).
AKIRIN1	metacluster_143.13	ZBTB7A (directAnnotation).
AKIRIN1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
AKIRIN1	metacluster_182.10	ZFX (directAnnotation).
AKIRIN1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
AKIRIN1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
AKIRIN1	hdpi__ELF2	ELF2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."