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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: AGPS

Summary for AGPS

Gene informationGene symbol

AGPS

Ensembl ID

ENSG00000018510

Entrez ID

8540

Gene namealkylglycerone phosphate synthase
SynonymsADAP-S|ADAS|ADHAPS|ADPS|ALDHPSY
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: AGPS

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.6690390.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.2513232.10e-11

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Expression of AGPS in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to AGPS

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AGPS

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
AGPShsa-miR-5011-5p99.968NM_003659
AGPShsa-miR-190a-3p99.7827NM_003659
AGPShsa-miR-365899.4177NM_003659
AGPShsa-miR-302a-5p97.0436NM_003659
AGPShsa-miR-323a-3p96.8859NM_003659
AGPShsa-miR-497-3p96.879NM_003659
AGPShsa-miR-60796.3047NM_003659
AGPShsa-miR-4735-5p94.9676NM_003659
AGPShsa-miR-675-3p94.9204NM_003659
AGPShsa-miR-590-3p94.4463NM_003659
AGPShsa-miR-548c-3p94.1486NM_003659
AGPShsa-miR-477593.0785NM_003659
AGPShsa-miR-548aj-3p92.7228NM_003659
AGPShsa-miR-548x-3p92.7228NM_003659
AGPShsa-miR-477392.607NM_003659
AGPShsa-miR-548ae-3p91.8481NM_003659
AGPShsa-miR-548j-3p91.8481NM_003659
AGPShsa-miR-548ah-3p91.8481NM_003659
AGPShsa-miR-548aq-3p91.8481NM_003659
AGPShsa-miR-548am-3p91.8481NM_003659
AGPShsa-miR-848591.264NM_003659
AGPShsa-miR-770291.2422NM_003659
AGPShsa-miR-582-5p90.3708NM_003659
AGPShsa-miR-314889.6549NM_003659
AGPShsa-miR-153-5p89.6412NM_003659
AGPShsa-miR-494-3p87.1158NM_003659
AGPShsa-miR-6734-3p87.114NM_003659
AGPShsa-miR-4762-3p86.9194NM_003659
AGPShsa-miR-3942-3p86.7251NM_003659
AGPShsa-miR-382-5p86.4438NM_003659
AGPShsa-miR-320a-3p86.2317NM_003659
AGPShsa-miR-320c86.2317NM_003659
AGPShsa-miR-320b86.2317NM_003659
AGPShsa-miR-320d86.2317NM_003659
AGPShsa-miR-442986.2317NM_003659
AGPShsa-miR-513a-5p86.029NM_003659
AGPShsa-miR-6833-5p85.6882NM_003659
AGPShsa-miR-135a-5p85.421NM_003659
AGPShsa-miR-135b-5p85.421NM_003659
AGPShsa-miR-501-5p85.3646NM_003659
AGPShsa-miR-24-3p84.2453NM_003659
AGPShsa-miR-316383.6519NM_003659
AGPShsa-miR-58683.3123NM_003659
AGPShsa-miR-6857-5p83.257NM_003659
AGPShsa-miR-627-3p82.3524NM_003659
AGPShsa-miR-5681b81.9212NM_003659
AGPShsa-miR-579-3p81.796NM_003659
AGPShsa-miR-1233-3p81.3091NM_003659
AGPShsa-miR-3664-3p81.1613NM_003659
AGPShsa-miR-684480.4457NM_003659
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Motifs and transcription factors (TFs) regulating AGPS

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
AGPSmetacluster_55.3E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
AGPStransfac_pro__M04826EP300 (directAnnotation).
AGPStaipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_reprE2F2 (directAnnotation).
AGPStaipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_methZNF385D (directAnnotation).
AGPShdpi__ETV4ETV4 (directAnnotation).
AGPSmetacluster_34.1ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
AGPSswissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
AGPSmetacluster_138.2ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
AGPSmetacluster_34.3EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
AGPSmetacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
AGPSmetacluster_144.3ZNF704; ZNF704 (directAnnotation).
AGPScisbp__M00968MTF2 (directAnnotation).
AGPSmetacluster_160.20JUND; PRDM15 (directAnnotation).
AGPSmetacluster_198.3ZFP64 (directAnnotation).
AGPSmetacluster_141.5NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
AGPSjaspar__MA0185.1DEAF1 (inferredBy_Orthology).
AGPSmetacluster_61.1DEAF1; DEAF1 (directAnnotation).
AGPSmetacluster_175.1ZNF283 (directAnnotation).
AGPSmetacluster_125.2TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
AGPSmetacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
AGPSmetacluster_151.2ZNF23 (directAnnotation).
AGPStransfac_public__M00189TFAP2A; TFAP2B; TFAP2C (directAnnotation).
AGPStransfac_pro__M03806ZBTB7C (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."