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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADGRL2

Summary for ADGRL2

Gene information	Gene symbol	ADGRL2
	Ensembl ID	ENSG00000117114
	Entrez ID	23266
	Gene name	adhesion G protein-coupled receptor L2
	Synonyms	CIRL2\|KIAA0786\|LEC1\|LPHH1\|LPHN2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ADGRL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	5.71898	6.87e-09
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.295744	1.21e-25

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Expression of ADGRL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADGRL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADGRL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADGRL2	hsa-miR-2113	99.4204	NM_012302
ADGRL2	hsa-miR-4307	99.4132	NM_012302
ADGRL2	hsa-miR-6844	99.0901	NM_001297706
ADGRL2	hsa-miR-627-3p	97.914	NM_012302
ADGRL2	hsa-miR-643	97.3475	NM_001297706
ADGRL2	hsa-miR-7-5p	96.4312	NM_012302
ADGRL2	hsa-miR-182-5p	95.8517	NM_001297706
ADGRL2	hsa-miR-5010-3p	95.8389	NM_012302
ADGRL2	hsa-miR-6077	95.3402	NM_012302
ADGRL2	hsa-miR-4437	95.072	NM_012302
ADGRL2	hsa-miR-6757-3p	94.0678	NM_012302
ADGRL2	hsa-miR-663b	92.6412	NM_012302
ADGRL2	hsa-miR-4708-3p	91.9081	NM_012302
ADGRL2	hsa-miR-6842-3p	90.7696	NM_012302
ADGRL2	hsa-miR-567	90.7686	NM_012302
ADGRL2	hsa-miR-4450	90.0867	NM_001297706
ADGRL2	hsa-miR-5187-5p	90.0379	NM_012302
ADGRL2	hsa-miR-3915	90.029	NM_001297706
ADGRL2	hsa-miR-487a-3p	89.9364	NM_012302
ADGRL2	hsa-miR-154-3p	89.9364	NM_012302
ADGRL2	hsa-let-7g-3p	89.7143	NM_012302
ADGRL2	hsa-let-7a-2-3p	89.7143	NM_012302
ADGRL2	hsa-miR-4646-3p	89.6241	NM_012302
ADGRL2	hsa-miR-6757-5p	89.5337	NM_012302
ADGRL2	hsa-miR-4530	88.7579	NM_012302
ADGRL2	hsa-miR-96-5p	88.7022	NM_001297706
ADGRL2	hsa-miR-4433b-5p	88.4915	NM_012302
ADGRL2	hsa-miR-3664-5p	87.5394	NM_012302
ADGRL2	hsa-miR-335-3p	86.705	NM_012302
ADGRL2	hsa-miR-3149	86.6441	NM_012302
ADGRL2	hsa-miR-297	86.4176	NM_012302
ADGRL2	hsa-miR-6511a-5p	86.1787	NM_012302
ADGRL2	hsa-miR-1910-3p	86.1787	NM_012302
ADGRL2	hsa-miR-12133	86.0413	NM_001297706
ADGRL2	hsa-miR-1271-5p	86.0413	NM_001297706
ADGRL2	hsa-miR-23a-3p	84.9906	NM_012302
ADGRL2	hsa-miR-23c	84.9906	NM_012302
ADGRL2	hsa-miR-23b-3p	84.9906	NM_012302
ADGRL2	hsa-miR-1972	84.5089	NM_012302
ADGRL2	hsa-miR-4321	84.4085	NM_001297706
ADGRL2	hsa-miR-548aj-3p	84.2766	NM_012302
ADGRL2	hsa-miR-548x-3p	84.2766	NM_012302
ADGRL2	hsa-miR-449c-3p	84.0088	NM_012302
ADGRL2	hsa-miR-561-3p	83.4519	NM_012302
ADGRL2	hsa-miR-520d-5p	82.4623	NM_012302
ADGRL2	hsa-miR-524-5p	82.4623	NM_012302
ADGRL2	hsa-miR-1248	82.3205	NM_001297706
ADGRL2	hsa-miR-205-3p	82.1487	NM_012302
ADGRL2	hsa-miR-5582-3p	81.5992	NM_012302
ADGRL2	hsa-miR-4496	81.1531	NM_012302

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Motifs and transcription factors (TFs) regulating ADGRL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADGRL2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ADGRL2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ADGRL2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ADGRL2	transfac_pro__M04617	ZBTB7A (directAnnotation).
ADGRL2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ADGRL2	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
ADGRL2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ADGRL2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ADGRL2	transfac_pro__M07387	ZBTB7A (directAnnotation).
ADGRL2	transfac_pro__M07436	WT1 (directAnnotation).
ADGRL2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ADGRL2	transfac_pro__M00716	ZBTB14 (directAnnotation).
ADGRL2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ADGRL2	hdpi__HIP2	UBE2K (directAnnotation).
ADGRL2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ADGRL2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ADGRL2	transfac_pro__M04893	TAF1 (directAnnotation).
ADGRL2	transfac_pro__M03876	ZBTB33 (directAnnotation).
ADGRL2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ADGRL2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ADGRL2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ADGRL2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ADGRL2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ADGRL2	metacluster_135.11	NR2C2 (directAnnotation).
ADGRL2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ADGRL2	tfdimers__MD00038	TFAP2C (directAnnotation).
ADGRL2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ADGRL2	metacluster_7.13	ZFX (directAnnotation).
ADGRL2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ADGRL2	cisbp__M00968	MTF2 (directAnnotation).
ADGRL2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ADGRL2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ADGRL2	cisbp__M00341	PAX6 (directAnnotation).
ADGRL2	metacluster_198.3	ZFP64 (directAnnotation).
ADGRL2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ADGRL2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ADGRL2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ADGRL2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ADGRL2	cisbp__M00788	ZFY (inferredBy_Orthology).
ADGRL2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ADGRL2	metacluster_175.1	ZNF283 (directAnnotation).
ADGRL2	hdpi__ZNF304	ZNF304 (directAnnotation).
ADGRL2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ADGRL2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ADGRL2	transfac_pro__M01199	TRIM28 (directAnnotation).
ADGRL2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ADGRL2	metacluster_151.2	ZNF23 (directAnnotation).
ADGRL2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ADGRL2	transfac_pro__M03806	ZBTB7C (directAnnotation).
ADGRL2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."