Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: A1CF

Summary for A1CF

Gene information	Gene symbol	A1CF
	Ensembl ID	ENSG00000148584
	Entrez ID	29974
	Gene name	APOBEC1 complementation factor
	Synonyms	ACF\|ACF64\|ACF65\|APOBEC1CF\|ASP
	Gene type	protein_coding
	UniProtAcc	Q9NQ94

Top

Dataset with differentially expressed gene: A1CF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.478936	3.78e-33

Top

Expression of A1CF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to A1CF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating A1CF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
A1CF	hsa-miR-590-3p	99.6133	NM_001198818
A1CF	hsa-miR-1252-5p	98.9184	NM_014576
A1CF	hsa-miR-651-3p	98.4929	NM_001198818
A1CF	hsa-miR-12124	97.9699	NM_014576
A1CF	hsa-miR-4282	97.2694	NM_001198818
A1CF	hsa-miR-5584-5p	97.1709	NM_014576
A1CF	hsa-miR-5692a	97.069	NM_001198818
A1CF	hsa-miR-29a-5p	97.0256	NM_001198818
A1CF	hsa-miR-4496	95.7728	NM_014576
A1CF	hsa-miR-3143	94.8597	NM_014576
A1CF	hsa-miR-30a-5p	94.4652	NM_001198818
A1CF	hsa-miR-30e-5p	94.4652	NM_001198818
A1CF	hsa-miR-30d-5p	94.4652	NM_001198818
A1CF	hsa-miR-30b-5p	94.4652	NM_001198818
A1CF	hsa-miR-30c-5p	94.4652	NM_001198818
A1CF	hsa-miR-7856-5p	93.6	NM_001198818
A1CF	hsa-miR-302b-5p	93.4162	NM_014576
A1CF	hsa-miR-302d-5p	93.4162	NM_014576
A1CF	hsa-miR-3686	93.015	NM_014576
A1CF	hsa-miR-4311	92.6424	NM_014576
A1CF	hsa-miR-4711-3p	92.5271	NM_014576
A1CF	hsa-miR-1283	92.3635	NM_014576
A1CF	hsa-miR-4520-3p	92.2865	NM_014576
A1CF	hsa-miR-4699-3p	92.0268	NM_014576
A1CF	hsa-miR-518a-5p	91.2803	NM_014576
A1CF	hsa-miR-527	91.2803	NM_014576
A1CF	hsa-miR-6895-3p	91.0679	NM_014576
A1CF	hsa-miR-7159-3p	90.8756	NM_014576
A1CF	hsa-miR-4470	90.7528	NM_001198818
A1CF	hsa-miR-511-5p	90.7349	NM_001198818
A1CF	hsa-miR-889-3p	89.4144	NM_014576
A1CF	hsa-miR-548av-5p	89.2949	NM_014576
A1CF	hsa-miR-548k	89.2949	NM_014576
A1CF	hsa-miR-8054	89.2949	NM_014576
A1CF	hsa-miR-4775	89.2616	NM_014576
A1CF	hsa-miR-6885-3p	88.8614	NM_014576
A1CF	hsa-miR-6867-5p	88.8096	NM_014576
A1CF	hsa-miR-8070	88.7922	NM_014576
A1CF	hsa-miR-494-3p	88.6696	NM_014576
A1CF	hsa-miR-12127	88.5123	NM_014576
A1CF	hsa-miR-3191-5p	88.4996	NM_014576
A1CF	hsa-miR-182-5p	88.1326	NM_001198818
A1CF	hsa-miR-4735-5p	87.3118	NM_014576
A1CF	hsa-miR-4652-3p	86.8582	NM_014576
A1CF	hsa-miR-4774-5p	86.548	NM_014576
A1CF	hsa-miR-302c-5p	86.4679	NM_014576
A1CF	hsa-miR-3942-3p	86.4526	NM_014576
A1CF	hsa-miR-4261	86.266	NM_001198818
A1CF	hsa-miR-4443	86.1377	NM_014576
A1CF	hsa-miR-1277-5p	86.0955	NM_014576

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating A1CF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."