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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PPIA

Summary for PPIA

Gene information	Gene symbol	PPIA
	Ensembl ID	ENSG00000196262
	Entrez ID	5478
	Gene name	peptidylprolyl isomerase A
	Synonyms	CYPA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PPIA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.576324	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.347562	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.318707	1.20e-30
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.296213	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.311594	5.34e-08
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.462884	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	-0.250688	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	-0.498285	9.96e-23
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.863577	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.452051	1.72e-37
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.36564	3.16e-04
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	-0.359081	6.15e-09
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	cDCs	0.283767	1.97e-06
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.409515	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD4+ T cells	0.314307	4.85e-34
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.934299	2.88e-25
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.359714	6.17e-15
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.264533	1.21e-36
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.286091	1.53e-06
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.809622	9.16e-11
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	-0.289317	5.72e-43
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.362265	4.11e-21
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.311247	3.46e-10
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.601455	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.321843	3.48e-09
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.74185	0.00e+00
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	post	Malignant cells	0.432421	0.00e+00
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	pre	Malignant cells	0.554544	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.322935	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.524392	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.538186	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	B cells	1.10425	8.58e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.609647	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.413881	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.72065	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.45188	4.48e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.448371	7.68e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.282452	1.94e-02
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.819035	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	NK cells	-0.259932	1.90e-12
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	CD8+ T cells	-0.277851	1.35e-29
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.314681	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.581532	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.293979	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.598798	0.00e+00

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Expression of PPIA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPIA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
PPIA	Erythrocytes	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	Erythrocytes	GSE199333	post	sensitive
PPIA	Erythrocytes	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	NK cells	Erythrocytes	GSE199333	post	sensitive
PPIA	B cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	B cells	Erythrocytes	GSE199333	post	sensitive
PPIA	CD4+ T cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	CD4+ T cells	Erythrocytes	GSE199333	post	sensitive
PPIA	NK cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	CD8+ T cells	NK cells	GSE199333	post	sensitive
PPIA	NK cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	NK cells	GSE199333	post	sensitive
PPIA	NK cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	NK cells	CD8+ T cells	GSE199333	post	sensitive
PPIA	NK cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	NK cells	Erythrocytes	GSE199333	post	sensitive
PPIA	NK cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	NK cells	Malignant cells	GSE199333	post	sensitive
PPIA	NK cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	NK cells	NK cells	GSE199333	post	sensitive
PPIA	NK cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	NK cells	GSE199333	pre	resistant
PPIA	NK cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	NK cells	Erythrocytes	GSE199333	pre	resistant
PPIA	NK cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	NK cells	Malignant cells	GSE199333	pre	resistant
PPIA	NK cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	NK cells	NK cells	GSE199333	pre	resistant
PPIA	CD8+ T cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	CD8+ T cells	Erythrocytes	GSE199333	pre	resistant
PPIA	NK cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	NK cells	Erythrocytes	GSE199333	pre	sensitive
PPIA	CD8+ T cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	CD8+ T cells	Erythrocytes	GSE199333	pre	sensitive
PPIA	B cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	B cells	Erythrocytes	GSE199333	pre	sensitive
PPIA	Neutrophils	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	B cells	Neutrophils	GSE207422_Sin	post	resistant
PPIA	Neutrophils	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	CD4+ T cells	Neutrophils	GSE207422_Sin	post	resistant
PPIA	Neutrophils	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	CD8+ T cells	Neutrophils	GSE207422_Sin	post	resistant
PPIA	Neutrophils	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Fibroblasts	Neutrophils	GSE207422_Sin	post	resistant
PPIA	Neutrophils	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	Neutrophils	GSE207422_Sin	post	resistant
PPIA	Neutrophils	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Mono/Macro	Neutrophils	GSE207422_Sin	post	resistant
PPIA	Neutrophils	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	pDCs	Neutrophils	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	B cells	Malignant cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	CD4+ T cells	Malignant cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	CD8+ T cells	Malignant cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Fibroblasts	Malignant cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	B cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	CD4+ T cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	CD8+ T cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	Fibroblasts	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	Malignant cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	Mast cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	Mono/Macro	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	NK cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	Neutrophils	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	Plasma cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	pDCs	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Mast cells	Malignant cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Mono/Macro	Malignant cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	NK cells	Malignant cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	pDCs	Malignant cells	GSE207422_Sin	post	resistant
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	Neutrophils	GSE207422_Sin	post	sensitive
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	Plasma cells	GSE207422_Sin	post	sensitive
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Malignant cells	pDCs	GSE207422_Sin	post	sensitive
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Mast cells	Malignant cells	GSE207422_Sin	post	sensitive
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	Mono/Macro	Malignant cells	GSE207422_Sin	post	sensitive
PPIA	Malignant cells	CPI-SS0E2453044	PPIA_BSG	PPIA	BSG	False	NK cells	Malignant cells	GSE207422_Sin	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPIA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPIA	hsa-miR-4456	91.8009	NM_021130
PPIA	hsa-miR-876-3p	91.569	NM_021130
PPIA	hsa-miR-892a	83.3666	NM_021130
PPIA	hsa-miR-6751-3p	82.105	NM_021130
PPIA	hsa-miR-1199-5p	82.105	NM_021130
PPIA	hsa-miR-4728-5p	80.2229	NM_021130

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Motifs and transcription factors (TFs) regulating PPIA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPIA	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
PPIA	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
PPIA	cisbp__M00808	MYPOP (inferredBy_Orthology).
PPIA	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
PPIA	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
PPIA	hdpi__TP73	TP73 (directAnnotation).
PPIA	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
PPIA	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
PPIA	jaspar__MA1957.1	ELK1 (directAnnotation).
PPIA	swissregulon__hs__ETV6	ETV6 (directAnnotation).
PPIA	transfac_pro__M05298	OVOL3 (directAnnotation).
PPIA	metacluster_33.5	MTF1 (inferredBy_Orthology).
PPIA	jaspar__MA1934.1	FIGLA (directAnnotation).
PPIA	transfac_pro__M06564	ZNF578 (directAnnotation).
PPIA	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
PPIA	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PPIA	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PPIA	transfac_pro__M04950	EGR1 (directAnnotation).
PPIA	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PPIA	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
PPIA	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PPIA	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PPIA	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
PPIA	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PPIA	transfac_pro__M00652	NRF1 (directAnnotation).
PPIA	transfac_pro__M04866	HDAC2 (directAnnotation).
PPIA	jaspar__MA1122.1	TFDP1 (directAnnotation).
PPIA	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PPIA	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
PPIA	transfac_pro__M05785	ZNF48 (inferredBy_Orthology).
PPIA	taipale_tf_pairs__HOXB2_TBX21_NGGTGTGNNNNNTMATTWGCRN_CAP_repr	HOXB2; TBX21 (directAnnotation).
PPIA	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
PPIA	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
PPIA	metacluster_161.2	LHX8 (directAnnotation).
PPIA	metacluster_161.4	LHX9 (directAnnotation).
PPIA	metacluster_141.2	E2F2; E2F3 (directAnnotation).
PPIA	jaspar__MA0063.2	NKX2-5 (directAnnotation).
PPIA	transfac_pro__M05542	SNAPC4 (directAnnotation).
PPIA	taipale_tf_pairs__TEAD4_ELK1_RGAATSCGGAAGYN_CAP	ELK1; TEAD4 (directAnnotation).
PPIA	transfac_pro__M06129	GLI4 (directAnnotation).
PPIA	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
PPIA	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PPIA	taipale_tf_pairs__E2F3_EOMES_NNGYGNNNNGGCGCSNNNNCRCNN_CAP_repr	E2F3; EOMES (directAnnotation).
PPIA	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PPIA	transfac_pro__M06259	ZNF91 (directAnnotation).
PPIA	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
PPIA	taipale_tf_pairs__E2F1_EOMES_RGGTGTNNNGGCGSNNTNNCRSNN_CAP	E2F1; EOMES (directAnnotation).
PPIA	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
PPIA	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PPIA	kznf__ZFP57_Imbeault2017_OM_MEME	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PPIA	"(3r)-1-Acetyl-3-Methylpiperidine"	DB01742	small molecule
PPIA	"Artenimol"	DB11638	small molecule
PPIA	"Copper"	DB09130	small molecule
PPIA	"Cyclosporine"	DB00091	small molecule
PPIA	"Ethyl Oxo(Piperidin-1-Yl)Acetate"	DB02419	small molecule
PPIA	"Proline"	DB00172	small molecule
PPIA	"Sanglifehrin A"	DB03393	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."