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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TGFB1

Summary for TGFB1

Gene information	Gene symbol	TGFB1
	Ensembl ID	ENSG00000105329
	Entrez ID	7040
	Gene name	transforming growth factor beta 1
	Synonyms	CED\|DPD1\|TGFB\|TGFbeta
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TGFB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.596839	2.31e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.331843	6.13e-05
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.309069	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	-0.32602	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	-0.356328	2.29e-04
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.253707	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	0.263808	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	-0.440006	4.88e-20
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	-0.564171	9.41e-40
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	cDCs	-0.323411	4.12e-02
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD4+ T cells	0.28977	5.79e-35
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.467209	1.67e-32
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	-0.39918	3.88e-06
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.566923	4.71e-06
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.398177	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.737259	0.00e+00
GSE212217	patients	Peripheral blood mononuclear cells	Endometrial cancer	Epigenetic MMRd endometrial carcinoma	Immunotherapy	pembrolizumab	post	NK cells	0.287839	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	CD8+ T cells	0.41565	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	CD4+ T cells	0.415161	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	-0.420117	2.27e-32
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	-0.389673	5.65e-43
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.351	1.12e-30
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	0.396053	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.478271	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.255731	1.70e-04
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.396515	2.49e-27
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.38328	2.62e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.410916	4.44e-28
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.271496	5.64e-42

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Expression of TGFB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TGFB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
TGFB1	CD4+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	CD4+ T cells	GSE197268_Tisa-cel	post	resistant
TGFB1	CD8+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD4+ T cells	CD8+ T cells	GSE197268_Tisa-cel	post	resistant
TGFB1	CD8+ T cells	CPI-SC01AADFEB3	TGFB1_TGFbeta_receptor2	TGFB1	NA	False	CD8+ T cells	CD4+ T cells	GSE197268_Tisa-cel	post	resistant
TGFB1	CD8+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD8+ T cells	CD4+ T cells	GSE197268_Tisa-cel	post	resistant
TGFB1	CD8+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD8+ T cells	CD8+ T cells	GSE197268_Tisa-cel	post	resistant
TGFB1	CD8+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD8+ T cells	NK cells	GSE197268_Tisa-cel	post	resistant
TGFB1	CD8+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	CD8+ T cells	GSE197268_Tisa-cel	post	resistant
TGFB1	CD8+ T cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	CD8+ T cells	NK cells	GSE197268_Tisa-cel	post	sensitive
TGFB1	CD8+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD8+ T cells	NK cells	GSE197268_Tisa-cel	post	sensitive
TGFB1	CD8+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	CD8+ T cells	GSE197268_Tisa-cel	post	sensitive
TGFB1	CD4+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD4+ T cells	CD8+ T cells	GSE197268_Tisa-cel	post	sensitive
TGFB1	CD4+ T cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	CD4+ T cells	NK cells	GSE197268_Tisa-cel	post	sensitive
TGFB1	CD4+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD4+ T cells	NK cells	GSE197268_Tisa-cel	post	sensitive
TGFB1	CD4+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	CD4+ T cells	GSE197268_Tisa-cel	post	sensitive
TGFB1	CD8+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD4+ T cells	CD8+ T cells	GSE197268_Tisa-cel	post	sensitive
TGFB1	CD8+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD8+ T cells	CD8+ T cells	GSE197268_Tisa-cel	post	sensitive
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD4+ T cells	NK cells	GSE197268_Tisa-cel	pre	resistant
TGFB1	NK cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	CD8+ T cells	NK cells	GSE197268_Tisa-cel	pre	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD8+ T cells	NK cells	GSE197268_Tisa-cel	pre	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	Mono/Macro	NK cells	GSE197268_Tisa-cel	pre	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	CD8+ T cells	GSE197268_Tisa-cel	pre	resistant
TGFB1	NK cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	NK cells	NK cells	GSE197268_Tisa-cel	pre	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	NK cells	GSE197268_Tisa-cel	pre	resistant
TGFB1	CD4+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD4+ T cells	NK cells	GSE197268_Tisa-cel	pre	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD4+ T cells	NK cells	GSE197268_Tisa-cel	pre	sensitive
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD8+ T cells	NK cells	GSE197268_Tisa-cel	pre	sensitive
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	CD8+ T cells	GSE197268_Tisa-cel	pre	sensitive
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	NK cells	GSE197268_Tisa-cel	pre	sensitive
TGFB1	CD4+ T cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD4+ T cells	NK cells	GSE197268_Tisa-cel	pre	sensitive
TGFB1	NK cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	CD4+ T cells	NK cells	GSE199333	post	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD4+ T cells	NK cells	GSE199333	post	resistant
TGFB1	NK cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	CD8+ T cells	NK cells	GSE199333	post	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD8+ T cells	NK cells	GSE199333	post	resistant
TGFB1	NK cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	Malignant cells	NK cells	GSE199333	post	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	Malignant cells	NK cells	GSE199333	post	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	CD8+ T cells	GSE199333	post	resistant
TGFB1	NK cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	NK cells	Malignant cells	GSE199333	post	resistant
TGFB1	NK cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	NK cells	NK cells	GSE199333	post	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	NK cells	GSE199333	post	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD8+ T cells	NK cells	GSE199333	post	sensitive
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	CD4+ T cells	GSE199333	post	sensitive
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	CD8+ T cells	GSE199333	post	sensitive
TGFB1	NK cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	NK cells	Malignant cells	GSE199333	post	sensitive
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	NK cells	NK cells	GSE199333	post	sensitive
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD4+ T cells	NK cells	GSE212217	post	resistant
TGFB1	NK cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	CD8+ T cells	NK cells	GSE212217	post	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	CD8+ T cells	NK cells	GSE212217	post	resistant
TGFB1	NK cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	Mono/Macro	NK cells	GSE212217	post	resistant
TGFB1	NK cells	CPI-SS085EE60B1	TGFB1_TGFBR3	TGFB1	TGFBR3	False	Mono/Macro	NK cells	GSE212217	post	resistant
TGFB1	NK cells	CPI-SC0DABCC4B5	TGFB1_TGFbeta_receptor1	TGFB1	NA	False	NK cells	CD8+ T cells	GSE212217	post	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
TGFB1	Regulation by the Disease Microenvironment
TGFB1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating TGFB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TGFB1	hsa-miR-663a	88.8343	NM_000660
TGFB1	hsa-miR-10396b-5p	84.4769	NM_000660
TGFB1	hsa-miR-6787-5p	84.4769	NM_000660
TGFB1	hsa-miR-1908-5p	84.4769	NM_000660
TGFB1	hsa-miR-7158-5p	82.9535	NM_000660
TGFB1	hsa-miR-6856-3p	81.2017	NM_000660
TGFB1	hsa-miR-3196	80.1201	NM_000660

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Motifs and transcription factors (TFs) regulating TGFB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TGFB1	cisbp__M02645	ETS1 (directAnnotation).
TGFB1	transfac_pro__M02869	HOXA3 (inferredBy_Orthology).
TGFB1	transfac_public__M00416	ALX1 (directAnnotation).
TGFB1	metacluster_32.25	ZNF287 (directAnnotation).
TGFB1	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
TGFB1	metacluster_32.28	ZFP28 (directAnnotation).
TGFB1	kznf__ZNF182_Imbeault2017_OM_RCADE	ZNF182 (directAnnotation).
TGFB1	metacluster_155.3	PLAG1 (directAnnotation). PLAG1 (inferredBy_Orthology).
TGFB1	transfac_pro__M01252	E2F6 (directAnnotation).
TGFB1	tfdimers__MD00454	ARID3A; PAX4 (directAnnotation).
TGFB1	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
TGFB1	metacluster_167.7	IRF8 (inferredBy_Orthology).
TGFB1	tfdimers__MD00336	IRF8; STAT1 (directAnnotation).
TGFB1	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
TGFB1	metacluster_160.15	ATF5; ATF5 (directAnnotation).
TGFB1	transfac_pro__M06711	ZNF160 (directAnnotation).
TGFB1	taipale_cyt_meth__ZNF396_NTGTMCGAAAN_FL_repr	ZNF396 (directAnnotation).
TGFB1	taipale_tf_pairs__GCM1_FOXI1_RTMAACATRNGGGN_CAP_repr	FOXI1; GCM1 (directAnnotation).
TGFB1	transfac_pro__M05582	ZNF426 (inferredBy_Orthology).
TGFB1	transfac_pro__M06918	ZNF652 (directAnnotation).
TGFB1	transfac_pro__M01884	IRF7 (directAnnotation).
TGFB1	tfdimers__MD00359	CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; STAT6 (directAnnotation).
TGFB1	transfac_pro__M05974	ZNF701 (directAnnotation).
TGFB1	transfac_pro__M06484	ZNF683 (directAnnotation).
TGFB1	hdpi__NME1	NME1 (directAnnotation).
TGFB1	transfac_pro__M04944	GABPA (directAnnotation).
TGFB1	transfac_public__M00271	RUNX1 (directAnnotation).
TGFB1	transfac_pro__M05791	ZNF517 (directAnnotation).
TGFB1	transfac_pro__M06971	ZNF521 (directAnnotation).
TGFB1	transfac_pro__M06643	ZNF583 (directAnnotation).
TGFB1	metacluster_22.32	NFE2L2 (directAnnotation).
TGFB1	hocomoco__SOX9_HUMAN.H11MO.1.B	SOX9 (directAnnotation).
TGFB1	transfac_pro__M04810	USF2 (directAnnotation).
TGFB1	tfdimers__MD00044	ELF1; ELF2; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV4; ETV6; ETV7; FLI1; GABPA; GABPB1; SIRT6; SPI1; SPIB (directAnnotation).
TGFB1	metacluster_130.1	ZNF713; ZNF713 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
TGFB1	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
TGFB1	tfdimers__MD00255	PAX7; PITX3 (directAnnotation).
TGFB1	tfdimers__MD00163	RARA; RARB; RARG; RXRA; RXRB; RXRG; THRA; THRB (directAnnotation).
TGFB1	hdpi__TIMELESS	TIMELESS (directAnnotation).
TGFB1	transfac_pro__M06313	ZNF678 (directAnnotation).
TGFB1	kznf__ZNF124_Imbeault2017_RP_RCADE	ZNF124 (directAnnotation).
TGFB1	swissregulon__mm__Atf2	ATF2 (inferredBy_Orthology).
TGFB1	transfac_pro__M06117	ZNF23 (directAnnotation).
TGFB1	swissregulon__hs__EZH2	EZH2 (directAnnotation).
TGFB1	tfdimers__MD00105	IRF8; PURA (directAnnotation).
TGFB1	tfdimers__MD00438	E2F1; NKX3-2 (directAnnotation).
TGFB1	transfac_pro__M06798	PRDM15 (directAnnotation).
TGFB1	transfac_pro__M05808	ZNF574 (directAnnotation).
TGFB1	transfac_pro__M06642	ZSCAN10 (directAnnotation).
TGFB1	metacluster_161.15	NKX3-1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TGFB1	"Foreskin fibroblast (neonatal)"	DB10770	biotech
TGFB1	"Foreskin keratinocyte (neonatal)"	DB10772	biotech
TGFB1	"Hyaluronidase (human recombinant)"	DB06205	biotech
TGFB1	"Hyaluronidase (ovine)"	DB00070	biotech
TGFB1	"Hyaluronidase"	DB14740	biotech
TGFB1	"Terazosin"	DB01162	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
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