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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VSIR

Summary for VSIR

Gene information	Gene symbol	VSIR
	Ensembl ID	ENSG00000107738
	Entrez ID	64115
	Gene name	V-set immunoregulatory receptor
	Synonyms	B7-H5\|B7H5\|C10orf54\|Dies1\|GI24\|PD-1H\|SISP1\|VISTA
	Gene type	protein_coding
	UniProtAcc	Q9H7M9

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Dataset with differentially expressed gene: VSIR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	-0.555267	1.19e-02
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.457615	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.454799	3.34e-12
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.364554	2.43e-08
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.37225	3.35e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.479536	4.97e-13
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Mono/Macro	-0.269435	1.52e-27
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Mono/Macro	-0.316628	6.89e-22
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.798305	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.550532	0.00e+00

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Expression of VSIR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VSIR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	B cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	B cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	CD4+ T cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	CD4+ T cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	Mono/Macro	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	Mono/Macro	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	NK cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	NK cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	Plasma cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	cDCs	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	pDCs	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	cDCs	Mono/Macro	GSE169246_PacAteBlood	pre	sensitive
VSIR	cDCs	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	cDCs	GSE169246_PacAteBlood	pre	sensitive
VSIR	cDCs	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	cDCs	CD4+ T cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	CD4+ T cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	cDCs	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	cDCs	CD8+ T cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	CD8+ T cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	cDCs	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	cDCs	Mono/Macro	GSE169246_PacAteBlood	pre	sensitive
VSIR	cDCs	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	cDCs	NK cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	NK cells	GSE169246_PacAteBlood	pre	sensitive
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	B cells	GSE169246_PacAteTissue	post	resistant
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	CD4+ T cells	GSE169246_PacAteTissue	post	resistant
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	B cells	GSE169246_PacAteTissue	post	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	B cells	GSE169246_PacAteTissue	post	sensitive
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	CD4+ T cells	GSE169246_PacAteTissue	post	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	CD4+ T cells	GSE169246_PacAteTissue	post	sensitive
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	post	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	post	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	Mono/Macro	GSE169246_PacAteTissue	post	sensitive
VSIR	Mono/Macro	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	Mono/Macro	NK cells	GSE169246_PacAteTissue	post	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	NK cells	GSE169246_PacAteTissue	post	sensitive
VSIR	Mono/Macro	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	Mono/Macro	pDCs	GSE169246_PacAteTissue	post	sensitive
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	B cells	GSE169246_PacTissue	pre	resistant
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	CD4+ T cells	GSE169246_PacTissue	pre	resistant
VSIR	cDCs	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	cDCs	CD8+ T cells	GSE169246_PacTissue	pre	resistant
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	CD8+ T cells	GSE169246_PacTissue	pre	resistant
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	NK cells	GSE169246_PacTissue	pre	resistant
VSIR	cDCs	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	cDCs	B cells	GSE169246_PacTissue	pre	sensitive
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	B cells	GSE169246_PacTissue	pre	sensitive
VSIR	cDCs	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	cDCs	CD4+ T cells	GSE169246_PacTissue	pre	sensitive
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	CD4+ T cells	GSE169246_PacTissue	pre	sensitive
VSIR	cDCs	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	cDCs	CD8+ T cells	GSE169246_PacTissue	pre	sensitive
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	CD8+ T cells	GSE169246_PacTissue	pre	sensitive
VSIR	cDCs	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	cDCs	Mono/Macro	GSE169246_PacTissue	pre	sensitive
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	Mono/Macro	GSE169246_PacTissue	pre	sensitive
VSIR	cDCs	CPI-SS017E5FA7F	VSIR_HLA-F	VSIR	HLA-F	False	cDCs	NK cells	GSE169246_PacTissue	pre	sensitive
VSIR	cDCs	CPI-SS0661FACAF	VSIR_HLA-E	VSIR	HLA-E	False	cDCs	NK cells	GSE169246_PacTissue	pre	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VSIR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VSIR	hsa-miR-4728-5p	90.7889	NM_022153
VSIR	hsa-miR-149-3p	85.8624	NM_022153
VSIR	hsa-miR-4492	85.3655	NM_022153
VSIR	hsa-miR-6785-5p	84.5608	NM_022153
VSIR	hsa-miR-6883-5p	84.0983	NM_022153

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Motifs and transcription factors (TFs) regulating VSIR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."