Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEMA4D

Summary for SEMA4D

Gene information	Gene symbol	SEMA4D
	Ensembl ID	ENSG00000187764
	Entrez ID	10507
	Gene name	semaphorin 4D
	Synonyms	C9orf164\|CD100\|coll-4\|FLJ39737\|SEMAJ
	Gene type	protein_coding
	UniProtAcc	Q92854

Top

Dataset with differentially expressed gene: SEMA4D

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.566216	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.38717	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.535948	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.320036	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.673097	2.21e-05

Top

Expression of SEMA4D in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SEMA4D

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
SEMA4D	NK cells	CPI-SS012F60F11	SEMA4D_PLXNB2	SEMA4D	PLXNB2	False	NK cells	cDCs	GSE169246_PacBlood	pre	sensitive
SEMA4D	NK cells	CPI-SS012F60F11	SEMA4D_PLXNB2	SEMA4D	PLXNB2	False	NK cells	pDCs	GSE169246_PacBlood	pre	sensitive
SEMA4D	NK cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	pDCs	NK cells	GSE169246_PacBlood	pre	sensitive
SEMA4D	CD4+ T cells	CPI-SS0BC7F3EB5	SEMA4D_CD72	SEMA4D	CD72	False	CD4+ T cells	B cells	GSE169246_PacBlood	pre	sensitive
SEMA4D	CD4+ T cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	CD4+ T cells	CD8+ T cells	GSE169246_PacBlood	pre	sensitive
SEMA4D	CD4+ T cells	CPI-SS012F60F11	SEMA4D_PLXNB2	SEMA4D	PLXNB2	False	CD4+ T cells	Mono/Macro	GSE169246_PacBlood	pre	sensitive
SEMA4D	CD4+ T cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	CD4+ T cells	NK cells	GSE169246_PacBlood	pre	sensitive
SEMA4D	CD4+ T cells	CPI-SS0BC7F3EB5	SEMA4D_CD72	SEMA4D	CD72	False	CD4+ T cells	cDCs	GSE169246_PacBlood	pre	sensitive
SEMA4D	CD4+ T cells	CPI-SS012F60F11	SEMA4D_PLXNB2	SEMA4D	PLXNB2	False	CD4+ T cells	cDCs	GSE169246_PacBlood	pre	sensitive
SEMA4D	CD4+ T cells	CPI-SS012F60F11	SEMA4D_PLXNB2	SEMA4D	PLXNB2	False	CD4+ T cells	pDCs	GSE169246_PacBlood	pre	sensitive
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	B cells	CD4+ T cells	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	B cells	CD8+ T cells	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS012F60F11	SEMA4D_PLXNB2	SEMA4D	PLXNB2	False	B cells	Malignant cells	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS0BC7F3EB5	SEMA4D_CD72	SEMA4D	CD72	False	B cells	Mono/Macro	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS012F60F11	SEMA4D_PLXNB2	SEMA4D	PLXNB2	False	B cells	Mono/Macro	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	B cells	NK cells	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	B cells	Neutrophils	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS012F60F11	SEMA4D_PLXNB2	SEMA4D	PLXNB2	False	B cells	pDCs	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	CD4+ T cells	B cells	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	CD8+ T cells	B cells	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	Mast cells	B cells	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	NK cells	B cells	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	Neutrophils	B cells	GSE207422_Tor	post	resistant
SEMA4D	B cells	CPI-SS0BC7F3EB5	SEMA4D_CD72	SEMA4D	CD72	False	B cells	B cells	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	B cells	B cells	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	B cells	CD4+ T cells	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	B cells	CD8+ T cells	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS012F60F11	SEMA4D_PLXNB2	SEMA4D	PLXNB2	False	B cells	Malignant cells	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0BC7F3EB5	SEMA4D_CD72	SEMA4D	CD72	False	B cells	Mono/Macro	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS012F60F11	SEMA4D_PLXNB2	SEMA4D	PLXNB2	False	B cells	Mono/Macro	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	B cells	Mono/Macro	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	B cells	NK cells	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	B cells	Neutrophils	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS012F60F11	SEMA4D_PLXNB2	SEMA4D	PLXNB2	False	B cells	pDCs	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0BC7F3EB5	SEMA4D_CD72	SEMA4D	CD72	False	CD4+ T cells	B cells	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	CD4+ T cells	B cells	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0BC7F3EB5	SEMA4D_CD72	SEMA4D	CD72	False	CD8+ T cells	B cells	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	CD8+ T cells	B cells	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0BC7F3EB5	SEMA4D_CD72	SEMA4D	CD72	False	Neutrophils	B cells	GSE207422_Tor	post	sensitive
SEMA4D	B cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	Neutrophils	B cells	GSE207422_Tor	post	sensitive
SEMA4D	CD8+ T cells	CPI-SS0F7113A7D	SEMA4D_PTPRC	SEMA4D	PTPRC	False	CD8+ T cells	CD8+ T cells	PMID34715028	post	resistant

Page: 1 2

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SEMA4D

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEMA4D	hsa-miR-4778-3p	97.7116	NM_006378
SEMA4D	hsa-miR-6128	96.7564	NM_006378
SEMA4D	hsa-miR-548at-5p	96.0427	NM_006378
SEMA4D	hsa-miR-3134	91.8835	NM_001142287
SEMA4D	hsa-miR-12119	91.1188	NM_001142287
SEMA4D	hsa-miR-4729	88.3786	NM_006378
SEMA4D	hsa-miR-875-3p	87.9225	NM_006378
SEMA4D	hsa-miR-5692a	87.4859	NM_006378
SEMA4D	hsa-miR-4319	86.1536	NM_006378
SEMA4D	hsa-miR-8080	85.9061	NM_006378
SEMA4D	hsa-miR-421	85.8354	NM_001142287
SEMA4D	hsa-miR-6754-3p	85.6984	NM_006378
SEMA4D	hsa-miR-3618	85.295	NM_006378
SEMA4D	hsa-miR-6830-5p	84.1332	NM_006378
SEMA4D	hsa-miR-412-3p	83.8703	NM_006378
SEMA4D	hsa-miR-1225-5p	83.65	NM_006378
SEMA4D	hsa-miR-1299	83.2766	NM_006378
SEMA4D	hsa-miR-125a-5p	82.9664	NM_006378
SEMA4D	hsa-miR-125b-5p	82.9664	NM_006378
SEMA4D	hsa-miR-9851-3p	82.8969	NM_001142287
SEMA4D	hsa-miR-4451	82.4643	NM_001142287
SEMA4D	hsa-miR-498-3p	82.2581	NM_001142287
SEMA4D	hsa-miR-122-5p	82.1418	NM_006378
SEMA4D	hsa-miR-4768-3p	82.0467	NM_001142287
SEMA4D	hsa-miR-212-5p	81.8217	NM_001142287

Page: 1

Top

Motifs and transcription factors (TFs) regulating SEMA4D

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEMA4D	jaspar__MA1955.1	FOXO1 (directAnnotation).
SEMA4D	transfac_pro__M04966	EP300 (directAnnotation).
SEMA4D	jaspar__MA1954.1	FOXO1 (directAnnotation).
SEMA4D	jaspar__MA1953.1	FOXO1 (directAnnotation).
SEMA4D	jaspar__MA1956.1	FOXO1 (directAnnotation).
SEMA4D	taipale_tf_pairs__FOXO1_ETV4_RWMAACAGGAARNN_CAP	ETV4; FOXO1 (directAnnotation).
SEMA4D	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
SEMA4D	jaspar__MA1952.1	FOXJ2 (directAnnotation).
SEMA4D	transfac_pro__M05803	ZNF584 (directAnnotation).
SEMA4D	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
SEMA4D	swissregulon__mm__Elf3	ELF3 (inferredBy_Orthology).
SEMA4D	kznf__ZNF555_Imbeault2017_RP_ChIP-seq	ZNF555 (directAnnotation).
SEMA4D	transfac_pro__M00655	ETV4 (directAnnotation).
SEMA4D	jaspar__MA1935.1	FOXI1 (directAnnotation).
SEMA4D	jaspar__MA1946.1	FOXI1 (directAnnotation).
SEMA4D	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."