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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD99

Summary for CD99

Gene information	Gene symbol	CD99
	Ensembl ID	ENSG00000002586
	Entrez ID	4267
	Gene name	CD99 molecule (Xg blood group)
	Synonyms	MIC2
	Gene type	protein_coding
	UniProtAcc	P14209

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Dataset with differentially expressed gene: CD99

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.340816	2.12e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.280586	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.422215	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.263578	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.344619	4.74e-28
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.468841	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-1.07825	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.303914	1.01e-03
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.374727	9.42e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.279485	1.87e-12
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	CD4+ T cells	-0.349692	1.80e-19
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.266973	2.00e-09
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	-0.456905	1.06e-05
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.317062	0.00e+00
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.270298	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	-0.27258	3.49e-14
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.293291	2.20e-23
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.319101	4.42e-40
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	NK cells	0.314045	3.43e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.379913	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	Malignant cells	0.383651	5.34e-39
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Malignant cells	0.739337	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.56002	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.778811	4.79e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	-0.402455	2.08e-09
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.546161	2.19e-25
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	NK cells	0.361942	8.22e-11
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.296475	6.88e-19
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.581038	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.286655	8.91e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.26126	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.369273	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.418986	0.00e+00

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Expression of CD99 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD99

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	B cells	Mono/Macro	GSE169246_PacAteTissue	post	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD4+ T cells	Mono/Macro	GSE169246_PacAteTissue	post	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD8+ T cells	Mono/Macro	GSE169246_PacAteTissue	post	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	NK cells	Mono/Macro	GSE169246_PacAteTissue	post	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	pDCs	Mono/Macro	GSE169246_PacAteTissue	post	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	B cells	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD4+ T cells	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD8+ T cells	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	Mast cells	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	Mono/Macro	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	NK cells	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	cDCs	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	B cells	Mono/Macro	GSE169246_PacAteTissue	pre	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD4+ T cells	Mono/Macro	GSE169246_PacAteTissue	pre	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD8+ T cells	Mono/Macro	GSE169246_PacAteTissue	pre	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	Mast cells	Mono/Macro	GSE169246_PacAteTissue	pre	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	Mono/Macro	Mono/Macro	GSE169246_PacAteTissue	pre	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	NK cells	Mono/Macro	GSE169246_PacAteTissue	pre	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	pDCs	Mono/Macro	GSE169246_PacAteTissue	pre	sensitive
CD99	NK cells	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	NK cells	Mono/Macro	GSE169246_PacBlood	post	resistant
CD99	NK cells	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	NK cells	cDCs	GSE169246_PacBlood	post	resistant
CD99	cDCs	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD8+ T cells	cDCs	GSE169246_PacBlood	post	resistant
CD99	cDCs	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	NK cells	cDCs	GSE169246_PacBlood	post	resistant
CD99	cDCs	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	Progenitors	cDCs	GSE169246_PacBlood	post	resistant
CD99	cDCs	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	cDCs	Mono/Macro	GSE169246_PacBlood	post	resistant
CD99	cDCs	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	pDCs	cDCs	GSE169246_PacBlood	post	resistant
CD99	CD8+ T cells	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD8+ T cells	Mono/Macro	GSE169246_PacBlood	post	resistant
CD99	CD8+ T cells	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD8+ T cells	cDCs	GSE169246_PacBlood	post	resistant
CD99	NK cells	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	NK cells	Mono/Macro	GSE169246_PacBlood	post	sensitive
CD99	NK cells	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	NK cells	cDCs	GSE169246_PacBlood	post	sensitive
CD99	cDCs	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD8+ T cells	cDCs	GSE169246_PacBlood	post	sensitive
CD99	cDCs	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	NK cells	cDCs	GSE169246_PacBlood	post	sensitive
CD99	cDCs	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	Progenitors	cDCs	GSE169246_PacBlood	post	sensitive
CD99	cDCs	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	cDCs	Mono/Macro	GSE169246_PacBlood	post	sensitive
CD99	cDCs	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	pDCs	cDCs	GSE169246_PacBlood	post	sensitive
CD99	CD8+ T cells	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD8+ T cells	Mono/Macro	GSE169246_PacBlood	post	sensitive
CD99	CD8+ T cells	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD8+ T cells	cDCs	GSE169246_PacBlood	post	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	Mono/Macro	Mono/Macro	GSE169246_PacBlood	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	Mono/Macro	cDCs	GSE169246_PacBlood	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	NK cells	Mono/Macro	GSE169246_PacBlood	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	Plasma cells	Mono/Macro	GSE169246_PacBlood	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	Progenitors	Mono/Macro	GSE169246_PacBlood	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	cDCs	Mono/Macro	GSE169246_PacBlood	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	pDCs	Mono/Macro	GSE169246_PacBlood	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	B cells	Mono/Macro	GSE169246_PacBlood	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD4+ T cells	Mono/Macro	GSE169246_PacBlood	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD8+ T cells	Mono/Macro	GSE169246_PacBlood	pre	resistant
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	B cells	Mono/Macro	GSE169246_PacBlood	pre	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD4+ T cells	Mono/Macro	GSE169246_PacBlood	pre	sensitive
CD99	Mono/Macro	CPI-SS01560CA22	CD99_PILRA	CD99	PILRA	False	CD8+ T cells	Mono/Macro	GSE169246_PacBlood	pre	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD99

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD99	hsa-miR-548n	97.1232	NM_001321367
CD99	hsa-miR-4275	91.7675	NM_001321367
CD99	hsa-miR-651-3p	91.4707	NM_001321367
CD99	hsa-miR-3928-5p	88.1666	NM_001321367
CD99	hsa-miR-6806-3p	88.1666	NM_001321367
CD99	hsa-miR-3658	88.081	NM_001321367
CD99	hsa-miR-548ay-5p	86.7432	NM_001321367
CD99	hsa-miR-548o-5p	86.7432	NM_001321367
CD99	hsa-miR-548ae-5p	86.7432	NM_001321367
CD99	hsa-miR-548bb-5p	86.7432	NM_001321367
CD99	hsa-miR-548b-5p	86.7432	NM_001321367
CD99	hsa-miR-548a-5p	86.7432	NM_001321367
CD99	hsa-miR-548ab	86.7432	NM_001321367
CD99	hsa-miR-548h-5p	86.7432	NM_001321367
CD99	hsa-miR-548d-5p	86.7432	NM_001321367
CD99	hsa-miR-548j-5p	86.7432	NM_001321367
CD99	hsa-miR-548aq-5p	86.7432	NM_001321367
CD99	hsa-miR-548au-5p	86.7432	NM_001321367
CD99	hsa-miR-548ap-5p	86.7432	NM_001321367
CD99	hsa-miR-548as-5p	86.7432	NM_001321367
CD99	hsa-miR-548ad-5p	86.7432	NM_001321367
CD99	hsa-miR-548i	86.7432	NM_001321367
CD99	hsa-miR-548w	86.7432	NM_001321367
CD99	hsa-miR-548c-5p	86.7432	NM_001321367
CD99	hsa-miR-548y	86.7432	NM_001321367
CD99	hsa-miR-548am-5p	86.7432	NM_001321367
CD99	hsa-miR-548ar-5p	86.7432	NM_001321367
CD99	hsa-miR-548ak	86.7432	NM_001321367
CD99	hsa-miR-559	86.7432	NM_001321367
CD99	hsa-miR-1288-5p	85.7277	NM_001321367
CD99	hsa-miR-197-3p	85.4674	NM_001321367
CD99	hsa-miR-3611	83.5453	NM_001321367
CD99	hsa-miR-376a-5p	80.8339	NM_001321367
CD99	hsa-miR-3646	80.4687	NM_001321367
CD99	hsa-miR-4699-5p	80.0814	NM_001321367

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Motifs and transcription factors (TFs) regulating CD99

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."