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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PECAM1

Summary for PECAM1

Gene information	Gene symbol	PECAM1
	Ensembl ID	ENSG00000261371
	Entrez ID	5175
	Gene name	platelet and endothelial cell adhesion molecule 1
	Synonyms	CD31
	Gene type	protein_coding
	UniProtAcc	P16284

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Dataset with differentially expressed gene: PECAM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	4.04916	1.19e-03
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.306965	2.92e-13
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	0.512269	2.08e-19
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.278308	5.55e-19
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.376613	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.37472	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.653113	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	0.405111	1.53e-06
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	pre	Malignant cells	-0.295039	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.314669	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.640519	0.00e+00

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Expression of PECAM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PECAM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
PECAM1	Malignant cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Malignant cells	Malignant cells	GSE161801_IMiD	pre	resistant
PECAM1	Malignant cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	Malignant cells	GSE161801_IMiD	pre	resistant
PECAM1	Malignant cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Progenitors	Malignant cells	GSE161801_IMiD	pre	resistant
PECAM1	Malignant cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	cDCs	Malignant cells	GSE161801_IMiD	pre	resistant
PECAM1	Malignant cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	pDCs	Malignant cells	GSE161801_IMiD	pre	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	Plasma cells	GSE169246_PacAteTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	B cells	GSE169246_PacAteTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	Mast cells	GSE169246_PacAteTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	NK cells	GSE169246_PacAteTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	Plasma cells	GSE169246_PacAteTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	pDCs	GSE169246_PacAteTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	pDCs	Plasma cells	GSE169246_PacAteTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	CD8+ T cells	Plasma cells	GSE169246_PacAteTissue	post	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mast cells	Plasma cells	GSE169246_PacAteTissue	post	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	Plasma cells	GSE169246_PacAteTissue	post	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	NK cells	Plasma cells	GSE169246_PacAteTissue	post	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	pDCs	Plasma cells	GSE169246_PacAteTissue	post	sensitive
PECAM1	Mono/Macro	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	Mast cells	GSE169246_PacAteTissue	pre	resistant
PECAM1	Mono/Macro	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	NK cells	GSE169246_PacAteTissue	pre	resistant
PECAM1	Mono/Macro	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	Plasma cells	GSE169246_PacAteTissue	pre	resistant
PECAM1	Mono/Macro	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	pDCs	GSE169246_PacAteTissue	pre	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	Plasma cells	GSE169246_PacAteTissue	pre	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	NK cells	Plasma cells	GSE169246_PacAteTissue	pre	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	Mast cells	GSE169246_PacAteTissue	pre	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	NK cells	GSE169246_PacAteTissue	pre	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	Plasma cells	GSE169246_PacAteTissue	pre	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	pDCs	GSE169246_PacAteTissue	pre	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	pDCs	Plasma cells	GSE169246_PacAteTissue	pre	resistant
PECAM1	Mono/Macro	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	B cells	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Mono/Macro	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Mono/Macro	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	Mono/Macro	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Mono/Macro	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	Plasma cells	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Mono/Macro	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	pDCs	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Mono/Macro	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	Mono/Macro	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Mono/Macro	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	pDCs	Mono/Macro	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	Plasma cells	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	B cells	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	CD8+ T cells	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	Mono/Macro	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	Plasma cells	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	pDCs	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	pDCs	Plasma cells	GSE169246_PacAteTissue	pre	sensitive
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	CD8+ T cells	Plasma cells	GSE169246_PacTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Mono/Macro	Plasma cells	GSE169246_PacTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	NK cells	GSE169246_PacTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	Plasma cells	GSE169246_PacTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	Plasma cells	pDCs	GSE169246_PacTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	pDCs	Plasma cells	GSE169246_PacTissue	post	resistant
PECAM1	Plasma cells	CPI-SS0E0DEA7D5	PECAM1_CD38	PECAM1	CD38	False	CD8+ T cells	Plasma cells	GSE169246_PacTissue	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PECAM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PECAM1	hsa-miR-6124	98.2788	NM_000442
PECAM1	hsa-miR-6867-5p	96.0093	NM_000442
PECAM1	hsa-miR-5680	92.9458	NM_000442
PECAM1	hsa-miR-1297	91.818	NM_000442
PECAM1	hsa-miR-6816-3p	90.0309	NM_000442
PECAM1	hsa-miR-7157-3p	89.6455	NM_000442
PECAM1	hsa-miR-6737-3p	88.322	NM_000442
PECAM1	hsa-miR-26a-5p	87.9441	NM_000442
PECAM1	hsa-miR-26b-5p	87.9441	NM_000442
PECAM1	hsa-miR-10399-3p	85.5126	NM_000442
PECAM1	hsa-miR-383-3p	85.0198	NM_000442
PECAM1	hsa-miR-4465	84.9344	NM_000442
PECAM1	hsa-miR-4293	83.5787	NM_000442
PECAM1	hsa-miR-299-3p	83.4023	NM_000442
PECAM1	hsa-miR-5008-3p	83.3275	NM_000442
PECAM1	hsa-miR-3125	80.3072	NM_000442
PECAM1	hsa-miR-873-5p	80.1731	NM_000442
PECAM1	hsa-miR-4311	80.0516	NM_000442

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Motifs and transcription factors (TFs) regulating PECAM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PECAM1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
PECAM1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
PECAM1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
PECAM1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
PECAM1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
PECAM1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
PECAM1	hdpi__TP73	TP73 (directAnnotation).
PECAM1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
PECAM1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
PECAM1	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
PECAM1	transfac_pro__M04748	GABPA (directAnnotation).
PECAM1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
PECAM1	transfac_pro__M01739	GTF2B (directAnnotation).
PECAM1	tfdimers__MD00138	IRF1; IRF2; IRF3; IRF4; IRF5; IRF7; IRF8; IRF9; MYB (directAnnotation).
PECAM1	metacluster_22.15	BACH1 (directAnnotation).
PECAM1	transfac_pro__M12628	LCOR (directAnnotation).
PECAM1	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
PECAM1	transfac_pro__M06168	ZNF85 (directAnnotation).
PECAM1	taipale_tf_pairs__HOXB13_EOMES_NNMRTAAANTMACACNN_CAP_repr	EOMES; HOXB13 (directAnnotation).
PECAM1	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
PECAM1	metacluster_44.33	HMX2 (directAnnotation).
PECAM1	metacluster_22.14	BACH1 (inferredBy_Orthology).
PECAM1	tfdimers__MD00501	ASCL1; BHLHE40; BHLHE41; HAND1; HAND2; LTF; MAX; MITF; MXD1; MXD3; MXD4; MXI1; MYC; MYCN; MYF5; MYF6; MYOD1; MYOG; NHLH1; TAL1; TAL2; TCF12; TCF3; TCF4; TFE3; TFEB; USF1; USF2 (directAnnotation).
PECAM1	tfdimers__MD00223	SOX9; TEAD1 (directAnnotation).
PECAM1	transfac_pro__M06732	ZNF304 (directAnnotation).
PECAM1	transfac_pro__M06131	ZNF10 (directAnnotation).
PECAM1	hocomoco__FOXJ3_HUMAN.H11MO.1.B	FOXJ3 (directAnnotation).
PECAM1	taipale_tf_pairs__HOXB2_SOX15_ACAAWRSNNNNYMATTA_CAP_repr	HOXB2; SOX15 (directAnnotation).
PECAM1	metacluster_145.5	SOX1 (directAnnotation).
PECAM1	transfac_pro__M06413	ZNF573 (directAnnotation).
PECAM1	transfac_pro__M04927	FOXA1 (directAnnotation).
PECAM1	transfac_pro__M01081	ZNF628 (directAnnotation).
PECAM1	transfac_pro__M06646	ZNF607 (directAnnotation).
PECAM1	metacluster_155.10	ZNF263; ZNF684; ZNF684; ZNF684; ZNF684 (directAnnotation).
PECAM1	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
PECAM1	transfac_pro__M06513	ZFP90 (directAnnotation).
PECAM1	metacluster_161.1	HOXA9 (directAnnotation).
PECAM1	metacluster_160.2	FEZF1; FEZF2 (directAnnotation).
PECAM1	tfdimers__MD00376	HOXA13; KLF4 (directAnnotation).
PECAM1	transfac_pro__M05779	ZNF674 (directAnnotation).
PECAM1	jaspar__MA1956.1	FOXO1 (directAnnotation).
PECAM1	jaspar__MA1946.1	FOXI1 (directAnnotation).
PECAM1	metacluster_179.5	MEF2A; MEF2A; MEF2A; MEF2A (directAnnotation).
PECAM1	metacluster_78.15	PAX7 (directAnnotation).
PECAM1	tfdimers__MD00078	HOXD1; TCF7L1 (directAnnotation).
PECAM1	tfdimers__MD00550	PITX3; TEAD1 (directAnnotation).
PECAM1	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."