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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene (This gene does not contain this module)
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: LGALS9

Summary for LGALS9

Gene information	Gene symbol	LGALS9
	Ensembl ID	ENSG00000168961
	Entrez ID	3965
	Gene name	galectin 9
	Synonyms	LGALS9A
	Gene type	protein_coding
	UniProtAcc	O00182

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Dataset with differentially expressed gene: LGALS9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	-0.294361	1.33e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.39782	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.29894	1.89e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.318592	7.36e-36
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.277781	1.14e-16
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.352811	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.527133	3.53e-19
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.576652	1.93e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.408768	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.857981	1.32e-05
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.644567	0.00e+00

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Expression of LGALS9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LGALS9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
LGALS9	cDCs	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	B cells	cDCs	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	cDCs	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	Mono/Macro	cDCs	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	Mono/Macro	cDCs	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	B cells	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	CD4+ T cells	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	CD8+ T cells	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	cDCs	Mono/Macro	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	Mono/Macro	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	cDCs	NK cells	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	NK cells	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	Plasma cells	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	cDCs	cDCs	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	cDCs	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	pDCs	GSE169246_PacAteBlood	pre	resistant
LGALS9	cDCs	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	B cells	cDCs	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	Mono/Macro	cDCs	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	Mono/Macro	cDCs	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	B cells	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	CD4+ T cells	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	CD8+ T cells	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	Mono/Macro	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	cDCs	NK cells	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	NK cells	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	Plasma cells	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	cDCs	cDCs	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	cDCs	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	cDCs	pDCs	GSE169246_PacAteBlood	pre	sensitive
LGALS9	cDCs	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	pDCs	cDCs	GSE169246_PacAteBlood	pre	sensitive
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	CD4+ T cells	GSE169246_PacAteTissue	post	resistant
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
LGALS9	B cells	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	B cells	Mast cells	GSE169246_PacAteTissue	post	resistant
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	Mast cells	GSE169246_PacAteTissue	post	resistant
LGALS9	B cells	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	B cells	Mono/Macro	GSE169246_PacAteTissue	post	resistant
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	Mono/Macro	GSE169246_PacAteTissue	post	resistant
LGALS9	B cells	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	B cells	NK cells	GSE169246_PacAteTissue	post	resistant
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	NK cells	GSE169246_PacAteTissue	post	resistant
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	Plasma cells	GSE169246_PacAteTissue	post	resistant
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	pDCs	GSE169246_PacAteTissue	post	resistant
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	Mono/Macro	B cells	GSE169246_PacAteTissue	post	resistant
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	Mono/Macro	GSE169246_PacAteTissue	post	sensitive
LGALS9	B cells	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	B cells	NK cells	GSE169246_PacAteTissue	post	sensitive
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	NK cells	GSE169246_PacAteTissue	post	sensitive
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	Plasma cells	GSE169246_PacAteTissue	post	sensitive
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	pDCs	GSE169246_PacAteTissue	post	sensitive
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	Mono/Macro	B cells	GSE169246_PacAteTissue	post	sensitive
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	CD4+ T cells	GSE169246_PacAteTissue	post	sensitive
LGALS9	B cells	CPI-SS0CE693E3E	LGALS9_P4HB	LGALS9	P4HB	False	B cells	CD8+ T cells	GSE169246_PacAteTissue	post	sensitive
LGALS9	B cells	CPI-SC0CF28722B	LGALS9_BCR_CD45_CD22	LGALS9	NA	False	B cells	Mast cells	GSE169246_PacAteTissue	post	sensitive
LGALS9	B cells	CPI-SS0E23CEB91	LGALS9_HAVCR2	LGALS9	HAVCR2	False	B cells	Mono/Macro	GSE169246_PacAteTissue	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LGALS9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

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Motifs and transcription factors (TFs) regulating LGALS9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LGALS9	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
LGALS9	tfdimers__MD00034	PDX1; SOX2 (directAnnotation).
LGALS9	metacluster_22.33	MAFK (inferredBy_Orthology).
LGALS9	metacluster_22.32	NFE2L2 (directAnnotation).
LGALS9	metacluster_22.37	BACH1 (directAnnotation).
LGALS9	metacluster_22.1	MAFF (inferredBy_Orthology).
LGALS9	taipale_tf_pairs__FLI1_MAX_RSCGGAANCACGTGN_CAP	FLI1; MAX (directAnnotation).
LGALS9	metacluster_22.19	NFE2 (directAnnotation).
LGALS9	metacluster_22.36	BACH2 (directAnnotation).
LGALS9	metacluster_22.20	MAFG (directAnnotation).
LGALS9	transfac_pro__M04826	EP300 (directAnnotation).
LGALS9	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
LGALS9	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
LGALS9	hdpi__TP73	TP73 (directAnnotation).
LGALS9	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
LGALS9	transfac_pro__M06032	ZNF727 (directAnnotation).
LGALS9	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
LGALS9	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
LGALS9	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
LGALS9	metacluster_168.11	ZNF771; ZNF771 (directAnnotation).
LGALS9	metacluster_22.18	BACH2 (inferredBy_Orthology).
LGALS9	metacluster_22.25	NFE2L2 (directAnnotation).
LGALS9	metacluster_22.29	NFE2 (directAnnotation).
LGALS9	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
LGALS9	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
LGALS9	metacluster_22.11	NFE2 (directAnnotation).
LGALS9	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
LGALS9	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
LGALS9	metacluster_22.13	MAFK (inferredBy_Orthology).
LGALS9	metacluster_22.17	NFE2 (directAnnotation).
LGALS9	taipale_tf_pairs__ERF_MAX_RSCGGAANCACGTGN_CAP_repr	ERF; MAX (directAnnotation).
LGALS9	transfac_pro__M05397	ZNF444 (directAnnotation).
LGALS9	metacluster_21.4	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
LGALS9	transfac_pro__M04699	MAFK (directAnnotation).
LGALS9	yetfasco__TBP-TFIIA-TFIIB_1330	GTF2B; TBPL2 (inferredBy_Orthology).
LGALS9	tfdimers__MD00409	ETS1; YY2 (directAnnotation).
LGALS9	metacluster_22.22	NFE2L2 (inferredBy_Orthology).
LGALS9	swissregulon__hs__ETV6	ETV6 (directAnnotation).
LGALS9	tfdimers__MD00395	NKX2-1; OTX1; OTX2 (directAnnotation).
LGALS9	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
LGALS9	transfac_pro__M06013	ZFP69B (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
LGALS9	"(R)-1-Para-Nitro-Phenyl-2-Azido-Ethanol"	DB04472	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."