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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene (This gene does not contain this module)
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CCL3

Summary for CCL3

Gene information	Gene symbol	CCL3
	Ensembl ID	ENSG00000278567
	Entrez ID	6348
	Gene name	C-C motif chemokine ligand 3
	Synonyms	G0S19-1\|LD78ALPHA\|MIP-1-alpha\|SCYA3
	Gene type	protein_coding
	UniProtAcc	P10147

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Dataset with differentially expressed gene: CCL3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	-0.324095	1.38e-20
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.687599	3.29e-34
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.398336	4.70e-04
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	1.15942	9.17e-29
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.317234	1.65e-20
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.618695	4.92e-06
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	1.29163	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	pDCs	0.304736	9.22e-04
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	2.57685	1.20e-42
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	NK cells	0.934072	1.74e-12
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Mono/Macro	1.39954	1.31e-37
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	1.46924	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	2.04277	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Malignant cells	-0.807946	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-1.61196	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.692133	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Mono/Macro	-1.04932	5.46e-41
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.793534	5.88e-30

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Expression of CCL3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCL3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	Mono/Macro	GSE161801_IMiD	post	resistant
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	cDCs	GSE161801_IMiD	post	resistant
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	Mono/Macro	GSE161801_IMiD	pre	resistant
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	Mono/Macro	GSE161801_IMiD	pre	resistant
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Mono/Macro	Mono/Macro	GSE161801_IMiD	pre	resistant
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	NK cells	Mono/Macro	GSE161801_IMiD	pre	resistant
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	Mono/Macro	GSE161801_PI	post	resistant
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	cDCs	GSE161801_PI	post	resistant
CCL3	NK cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	NK cells	Mono/Macro	GSE161801_PI	post	resistant
CCL3	NK cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	NK cells	cDCs	GSE161801_PI	post	resistant
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	Mono/Macro	GSE161801_PI	pre	resistant
CCL3	CD8+ T cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	CD8+ T cells	Mono/Macro	GSE161801_PI	pre	resistant
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	CD8+ T cells	Mono/Macro	GSE161801_PI	pre	resistant
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	Mono/Macro	GSE161801_PI	pre	resistant
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Mono/Macro	Mono/Macro	GSE161801_PI	pre	resistant
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	CD8+ T cells	Malignant cells	GSE162117	pre	resistant
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	cDCs	Malignant cells	GSE162117	pre	resistant
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	Malignant cells	GSE162117	pre	sensitive
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	NK cells	Malignant cells	GSE162117	pre	sensitive
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Mono/Macro	Mono/Macro	GSE169246_PacAteTissue	post	resistant
CCL3	NK cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	NK cells	Mono/Macro	GSE169246_PacTissue	post	resistant
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Mono/Macro	Mono/Macro	GSE169246_PacTissue	pre	resistant
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	cDCs	Mono/Macro	GSE169246_PacTissue	pre	resistant
CCL3	Mono/Macro	CPI-SS0C090A257	CCL3_CCR5	CCL3	CCR5	False	Mono/Macro	CD8+ T cells	GSE169246_PacTissue	pre	sensitive
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Mono/Macro	Mono/Macro	GSE169246_PacTissue	pre	sensitive
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Mono/Macro	cDCs	GSE169246_PacTissue	pre	sensitive
CCL3	Mono/Macro	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	cDCs	Mono/Macro	GSE169246_PacTissue	pre	sensitive
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	Mono/Macro	GSE189460	pre	resistant
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	cDCs	GSE189460	pre	resistant
CCL3	Malignant cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Malignant cells	Mono/Macro	GSE189460	pre	sensitive
CCL3	NK cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	NK cells	Mono/Macro	GSE197268_Tisa-cel	post	resistant
CCL3	NK cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	NK cells	Mono/Macro	GSE197268_Tisa-cel	post	sensitive
CCL3	NK cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	NK cells	Malignant cells	GSE199333	post	sensitive
CCL3	CD8+ T cells	CPI-SS0C090A257	CCL3_CCR5	CCL3	CCR5	False	CD8+ T cells	CD4+ T cells	GSE207422_Sin	post	resistant
CCL3	CD8+ T cells	CPI-SS0C090A257	CCL3_CCR5	CCL3	CCR5	False	CD8+ T cells	CD8+ T cells	GSE207422_Sin	post	resistant
CCL3	CD8+ T cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	CD8+ T cells	Mono/Macro	GSE207422_Sin	post	resistant
CCL3	CD8+ T cells	CPI-SS0C090A257	CCL3_CCR5	CCL3	CCR5	False	CD8+ T cells	Mono/Macro	GSE207422_Sin	post	resistant
CCL3	CD8+ T cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	CD8+ T cells	Neutrophils	GSE207422_Sin	post	resistant
CCL3	CD8+ T cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	Mono/Macro	CD8+ T cells	GSE207422_Sin	post	resistant
CCL3	CD8+ T cells	CPI-SS0C090A257	CCL3_CCR5	CCL3	CCR5	False	Mono/Macro	CD8+ T cells	GSE207422_Sin	post	resistant
CCL3	CD8+ T cells	CPI-SS0C090A257	CCL3_CCR5	CCL3	CCR5	False	NK cells	CD8+ T cells	GSE207422_Sin	post	resistant
CCL3	CD8+ T cells	CPI-SS0C090A257	CCL3_CCR5	CCL3	CCR5	False	Neutrophils	CD8+ T cells	GSE207422_Sin	post	resistant
CCL3	CD8+ T cells	CPI-SS0C090A257	CCL3_CCR5	CCL3	CCR5	False	CD8+ T cells	CD8+ T cells	GSE207422_Sin	post	sensitive
CCL3	CD8+ T cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	CD8+ T cells	Mono/Macro	GSE207422_Sin	post	sensitive
CCL3	CD8+ T cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	CD8+ T cells	Neutrophils	GSE207422_Sin	post	sensitive
CCL3	CD8+ T cells	CPI-SS0C090A257	CCL3_CCR5	CCL3	CCR5	False	Mono/Macro	CD8+ T cells	GSE207422_Sin	post	sensitive
CCL3	CD8+ T cells	CPI-SS0C090A257	CCL3_CCR5	CCL3	CCR5	False	NK cells	CD8+ T cells	GSE207422_Sin	post	sensitive
CCL3	CD8+ T cells	CPI-SS0C090A257	CCL3_CCR5	CCL3	CCR5	False	CD8+ T cells	CD8+ T cells	GSE207422_Tor	post	resistant
CCL3	CD8+ T cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	CD8+ T cells	Mono/Macro	GSE207422_Tor	post	resistant
CCL3	CD8+ T cells	CPI-SS08DA48A5A	CCL3_CCR1	CCL3	CCR1	False	CD8+ T cells	Neutrophils	GSE207422_Tor	post	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCL3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

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Motifs and transcription factors (TFs) regulating CCL3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCL3	transfac_pro__M06042	ZNF208 (directAnnotation).
CCL3	transfac_pro__M05440	NKX2-3 (directAnnotation).
CCL3	tfdimers__MD00602	MYB; STAT6 (directAnnotation).
CCL3	metacluster_141.2	E2F2; E2F3 (directAnnotation).
CCL3	taipale_cyt_meth__POU6F1_NTAATKAGSN_FL_meth	POU6F1 (directAnnotation).
CCL3	transfac_pro__M06557	ZNF418 (directAnnotation).
CCL3	taipale_cyt_meth__HSF5_AACRTTCTAGAAYGYT_eDBD_meth	HSF5 (directAnnotation).
CCL3	dbtfbs__NCOA3_MCF-7_ENCSR573OJP_merged_N2	NCOA3 (directAnnotation).
CCL3	transfac_pro__M05884	ZNF439 (directAnnotation).
CCL3	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
CCL3	transfac_public__M00095	CUX1 (directAnnotation).
CCL3	transfac_pro__M06346	E4F1 (directAnnotation).
CCL3	transfac_pro__M05482	ZNF202 (directAnnotation).
CCL3	taipale_tf_pairs__HOXD12_ETV1_RSCGGAAGTAATAAAN_CAP	ETV1; HOXD12 (directAnnotation).
CCL3	transfac_pro__M05804	ZBTB41 (inferredBy_Orthology).
CCL3	metacluster_21.4	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
CCL3	transfac_pro__M05411	ZNF784 (inferredBy_Orthology).
CCL3	metacluster_56.3	HSF2 (directAnnotation).
CCL3	tfdimers__MD00421	ELF3; POU5F1 (directAnnotation).
CCL3	transfac_pro__M05393	ZBTB6 (inferredBy_Orthology).
CCL3	transfac_pro__M06272	ZNF569 (directAnnotation).
CCL3	transfac_pro__M05791	ZNF517 (directAnnotation).
CCL3	transfac_pro__M06469	ZNF441 (directAnnotation).
CCL3	transfac_pro__M06501	ZNF76 (inferredBy_Orthology).
CCL3	transfac_pro__M07448	ZBED1 (directAnnotation).
CCL3	transfac_pro__M04706	RELA (directAnnotation).
CCL3	taipale__Esrra_DBD_TTCAAGGTCAN_repr	ESRRA (inferredBy_Orthology).
CCL3	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
CCL3	metacluster_22.42	MAFG (directAnnotation).
CCL3	transfac_pro__M05667	ZNF35 (directAnnotation).
CCL3	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
CCL3	transfac_pro__M04933	STAT3 (directAnnotation).
CCL3	tfdimers__MD00449	REL; YY1 (directAnnotation).
CCL3	metacluster_155.13	ZNF135 (directAnnotation).
CCL3	transfac_pro__M06603	ZNF560 (directAnnotation).
CCL3	transfac_pro__M05560	AEBP2 (directAnnotation).
CCL3	transfac_pro__M05640	ZNF735 (directAnnotation).
CCL3	metacluster_22.18	BACH2 (inferredBy_Orthology).
CCL3	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
CCL3	tfdimers__MD00212	NFATC1; NFIA; NFIC (directAnnotation).
CCL3	taipale_tf_pairs__GCM1_TBX21_RGGTGWKNNNNNNNNNTNNCRTRNGGGN_CAP_repr	GCM1; TBX21 (directAnnotation).
CCL3	tfdimers__MD00217	LTF; MZF1 (directAnnotation).
CCL3	transfac_pro__M02830	ZSCAN26 (inferredBy_Orthology).
CCL3	transfac_pro__M05574	ZFP92 (directAnnotation).
CCL3	transfac_public__M00285	NFE2L1 (directAnnotation).
CCL3	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
CCL3	transfac_pro__M06326	ZNF841 (directAnnotation).
CCL3	metacluster_29.2	BCL6; IRF3; IRF3; STAT1; STAT1; STAT1; STAT2; STAT3; STAT3; STAT3; STAT4; STAT4; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT5B; STAT6 (directAnnotation). STAT3; STAT5A; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT6; STAT6 (inferredBy_Orthology).
CCL3	transfac_pro__M05717	ZNF134; ZNF154; ZNF256; ZNF304; ZNF418; ZNF419; ZNF480; ZNF548; ZNF549; ZNF552; ZNF561; ZNF562; ZNF584; ZNF586; ZNF587B; ZNF610; ZNF772; ZNF773; ZNF792; ZNF793; ZNF837 (inferredBy_Orthology).
CCL3	tfdimers__MD00321	FLI1; ING4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CCL3	"ROX-888"	DB05364	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."