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Center for Computational Systems Medicine
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Dataset summary

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Drug summary

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Umap of single cell types and conditions (resistant and sensitive)

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Comparison of cell composition between the resistant and sensitive groups (This dataset does not contain this module)

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Comparison of intra-tumor heterogeneity (ITH) and epithelial-mesenchymal transition (EMT) scores of malignant cells between the resistant and sensitive groups

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Difference of cell-cell interactions between the resistant and sensitive groups

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Differentially expressed genes (DEGs) between the resistant and sensitive groups for each cell type

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Mechanism analysis of drug resistance-related DEGs for each cell type in the pre-treatment samples (This dataset does not contain this module)

Soverview

Mechanism analysis of drug resistance-related DEGs for each cell type in the post-treatment samples

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Mechanism analysis of drug resistance-related DEGs for each cell type in one patient or cell lines (This dataset does not contain this module)

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MicroRNAs (miRNAs) regulating drug resistance-related DEGs for Malignant cells

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Motifs and transcription factors (TFs) regulating drug resistance-related DEGs for each cell type

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Differentially expressed genes act as transcription factors

Dataset: GSE207422_Tor

Dataset summary for GSE207422_Tor

Datast informationDatasetGSE207422_Tor
PMID36869384
Raw data ID/linkhttps://ngdc.cncb.ac.cn/gsa-human/browse/HRA001033
OrganismHomo sapiens
Sourcepatients
TissueTumor tissue
Cancer type level1Lung cancer
Cancer type level2EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)
Regimentoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)
Drug typeImmunotherapy
Sample sizepost (resistant 3, sensitive 2)
Cell number8690
Extract protocolBD Rhapsody system
Data processing BD Rhapsody Whole Transcriptome Analysis (WTA) Pipeline
Public datePublic on Mar 21, 2023
DescriptionThis dataset has 5 patients with post-treatment samples.

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Drug summary for GSE207422_Tor

Drug nameDrugBank IDDrug typeTargets nameTargets uniprot ID
"Toripalimab"

DB15043

biotechPDCD1Q15116
"carboplatin" is not included in the drug list.
"Docetaxel"

DB01248

small moleculeTUBB1; MAP2; MAP4; MAPT; BCL2; NR1I2Q9H4B7; P11137; P27816; P10636; P10415; O75469
"Pemetrexed"

DB00642

small moleculeTYMS; ATIC; DHFR; GARTP04818; P31939; P00374; P22102
"emcitabine" is not included in the drug list.

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Umap of single cell types and conditions (resistant and sensitive)

check buttonUmap of cell types and conditions (resistant and sensitive). If this dataset has both pre-treatment and post-treatment samples, the cell types were annotated together. If this dataset is a cell line dataset, the UMAP of cell clusters and the cell ratio of drug-resistant and sensitive groups within each cluster will also be shown. (If the image exists, the user can click on it to enlarge it in a new window.)
Umap of cell typesboxplotUmap of conditionsboxplot

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Comparison of cell composition between the resistant and sensitive groups

check buttonIn the pre-treatment samples, the cell composition of the resistant and sensitive groups were compared.
* represents significant difference. (If the image exists, the user can click on it to enlarge it in a new window.)

check buttonIn the post-treatment samples, the cell composition of the resistant and sensitive groups were compared.
* represents significant difference. (If the image exists, the user can click on it to enlarge it in a new window.)

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Comparison of ITH and EMT scores of malignant cells between the resistant and sensitive groups

check buttonComparison of ITH (intra-tumoral heterogeneity) and EMT (epithelial-mesenchymal transition) scores of malignant cells between the resistant and sensitive groups. ITH represents intratumoral heterogeneity, EMT represents epithelial mesenchymal transition, pre represents pre-treatment, post represents post-treatment, post2 represents longer post-treatment. (If the image exists, the user can click on it to enlarge it in a new window.)
Comparison of ITH scoresboxplotComparison of EMT scoresboxplot

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Difference of cell-cell interactions between the resistant and sensitive groups

check buttonIn the pre-treatment samples, the difference in cell-cell interactions between the resistant and sensitive groups was compared. The numbers indicate the count of cell-cell interactions that were either higher or lower in the resistant group compared to the sensitive group. The dot plots of significant ligand-receptor pairs in the resistant group and sensitive group are subsequently displayed. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

check buttonIn the post-treatment samples, the difference in cell-cell interactions between the resistant and sensitive groups was compared. The numbers indicate the count of cell-cell interactions that were either higher or lower in the resistant group compared to the sensitive group. The dot plots of significant ligand-receptor pairs in the resistant group and sensitive group are subsequently displayed. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

resistant vs. sensitive

boxplot
Dot plot of significant ligand-receptor pairs in the resistant groupDot plot of significant ligand-receptor pairs in the sensitive group
boxplotboxplot

check buttonThis dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. The difference in cell-cell interactions between the resistant and sensitive groups was compared. The numbers indicate the count of cell-cell interactions that were either higher or lower in the resistant group compared to the sensitive group. The dot plots of significant ligand-receptor pairs in the resistant group and sensitive group are subsequently displayed. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

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Differentially expressed genes (DEGs) between the resistant and sensitive groups for each cell type

check buttonIn the pre-treatment samples, the differentially expressed genes (|avg_log2FC|>0.25 & p_val_adj<0.05) between the resistant and sensitive groups for each cell type.

check buttonIn the post-treatment samples, the differentially expressed genes (|avg_log2FC|>0.25 & p_val_adj<0.05) between the resistant and sensitive groups for each cell type.
Gene symbolGene idavg_log2FCp_valp_val_adjpct.1pct.2Cell typeTimepoint

CALM1

ENSG000001986680.3889433.34e-107.50e-060.890.795Mono/Macropost

SLC16A10

ENSG000001123940.3805563.61e-128.12e-080.2730.045Mono/Macropost

MMP19

ENSG000001233420.3709351.00e-082.25e-040.330.125Mono/Macropost

ANP32B

ENSG000001369380.3674322.91e-106.55e-060.6340.415Mono/Macropost

THBD

ENSG000001787260.3658081.37e-063.08e-020.3220.15Mono/Macropost

DDIT4

ENSG000001682090.3644023.22e-087.23e-040.3360.14Mono/Macropost

BHLHE40

ENSG000001341070.3636741.23e-072.77e-030.4470.26Mono/Macropost

PPDPF

ENSG000001255340.3631599.00e-112.02e-060.4060.17Mono/Macropost

DDX3X

ENSG000002153010.3618761.42e-083.18e-040.4970.295Mono/Macropost

MARCKS

ENSG000002774430.3583971.68e-063.78e-020.7150.585Mono/Macropost

TNFRSF1B

ENSG000000281370.3579751.48e-073.32e-030.4250.24Mono/Macropost

SIGLEC12

ENSG000002545210.3522656.77e-111.52e-060.2550.045Mono/Macropost

ARL5B

ENSG000001659970.3469371.98e-094.46e-050.2570.065Mono/Macropost

SDS

ENSG000001350940.3463995.33e-071.20e-020.4940.29Mono/Macropost

EEF1A1

ENSG000001565080.3454221.10e-112.47e-070.9990.995Mono/Macropost

GABARAPL1

ENSG000001391120.3452145.62e-111.26e-060.3380.1Mono/Macropost

KDM6B

ENSG000001325100.3415931.43e-083.22e-040.3090.115Mono/Macropost

ATP2B1

ENSG000000709610.3396626.41e-081.44e-030.4010.205Mono/Macropost

CDKN1A

ENSG000001247620.3333292.17e-084.88e-040.5120.29Mono/Macropost

SELENOK

ENSG000001138110.3268622.30e-095.17e-050.3190.11Mono/Macropost

CSRNP1

ENSG000001446550.3217181.04e-112.34e-070.3090.075Mono/Macropost

OAS3

ENSG000001113310.3118368.54e-081.92e-030.3320.145Mono/Macropost

APLP2

ENSG000000842340.3115996.39e-071.43e-020.8490.8Mono/Macropost

TXN

ENSG000001368100.308571.00e-072.25e-030.6330.41Mono/Macropost

PDE4B

ENSG000001845880.3082826.28e-071.41e-020.3180.15Mono/Macropost

GNA13

ENSG000001200630.3064558.05e-081.81e-030.4260.225Mono/Macropost

LY6E

ENSG000002780320.3035041.01e-062.27e-020.4560.275Mono/Macropost

PTGER4

ENSG000001715220.3033052.05e-064.61e-020.3830.215Mono/Macropost

NFIL3

ENSG000001650300.3031488.15e-101.83e-050.280.075Mono/Macropost

MT-RNR2

ENSG000002100820.3018882.06e-144.63e-100.9991Mono/Macropost

COX6C

ENSG000001649190.3012582.37e-085.31e-040.6810.53Mono/Macropost

EEF1D

ENSG000002735940.2980811.95e-074.38e-030.3870.2Mono/Macropost

ELL2

ENSG000001189850.2951162.71e-076.09e-030.3320.155Mono/Macropost

EZR

ENSG000000928200.2941819.87e-072.22e-020.2960.13Mono/Macropost

METRNL

ENSG000002750310.2923594.02e-079.04e-030.4250.245Mono/Macropost

PIM3

ENSG000001983550.289061.76e-063.95e-020.3150.155Mono/Macropost

EIF4A2

ENSG000001569760.2809846.33e-071.42e-020.4740.3Mono/Macropost

RIPK2

ENSG000001043120.2800772.37e-085.32e-040.2690.085Mono/Macropost

DEDD2

ENSG000001605700.2746221.94e-084.35e-040.2850.095Mono/Macropost

DDX3Y

ENSG000000670480.2684441.93e-064.34e-020.3230.16Mono/Macropost

ETS2

ENSG000001575570.2665511.41e-063.17e-020.320.15Mono/Macropost

RASGEF1B

ENSG000001386700.2628.08e-081.81e-030.4990.285Mono/Macropost

ANXA1

ENSG000001350460.253498.25e-081.85e-030.7330.51Mono/Macropost

XBP1

ENSG000001002190.2522232.02e-074.54e-030.3270.14Mono/Macropost

CERS2

ENSG000001434180.250697.01e-071.58e-020.3370.165Mono/Macropost

PSTPIP2

ENSG00000152229-0.2505981.52e-083.41e-040.1290.285Mono/Macropost

MT-CO2

ENSG00000198712-0.2512675.79e-181.30e-130.9990.99Mono/Macropost

KCTD12

ENSG00000178695-0.25471.51e-063.39e-020.6890.795Mono/Macropost

PILRA

ENSG00000085514-0.2582212.14e-084.81e-040.3320.535Mono/Macropost

GDI2

ENSG00000057608-0.2583043.96e-088.90e-040.5010.67Mono/Macropost
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check buttonThis dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. The following are differentially expressed genes (|avg_log2FC|>0.25 & p_val_adj<0.05) between the resistant and sensitive groups for each cell type.

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Mechanism analysis of drug resistance-related DEGs for each cell type in the pre-treatment samples

check buttonEnrichment results for 5 known drug-resistant mechanisms in malignant cells and 1 known mechanism in TME cells.The "Signature" column represents the differentially expressed genes (DEGs) used for enrichment. The "Geneset" column represents the genes included in this mechanism. The "Overlap" column represents the number of genes in the "Geneset" that are enriched in the "Signature". The "Enriched Genes" column represents the genes in the "Geneset" that are enriched in the "Signature". (If the image exists, the user can click on it to enlarge it in a new window.)

check buttonHallmark, KEGG and GOBP enrichment results for up-regulated genes in resistant group of pre-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

check buttonHallmark, KEGG and GOBP enrichment results for down-regulated genes in resistant group of pre-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window.Complete files can be downloaded from the download section.)

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Mechanism analysis of drug resistance-related DEGs for each cell type in the post-treatment samples

check buttonEnrichment results for 5 known drug resistance mechanisms in malignant cells and 1 known mechanism in TME cells.The "Signature" column represents the differentially expressed genes (DEGs) used for enrichment. The "Geneset" column represents the genes included in this mechanism. The "Overlap" column represents the number of genes in the "Geneset" that are enriched in the "Signature". The "Enriched Genes" column represents the genes in the "Geneset" that are enriched in the "Signature". (If the image exists, the user can click on it to enlarge it in a new window.)
Enrichment results for 5 known drug resistance mechanisms in malignant cells
boxplot
MechnismPvalFDRSignatureGenesetOverlapBackgroundCell typeEnriched Genes
Unusual Activation of Pro-survival Pathway1.00e-225.10e-229457819623467Malignant cellsPPP2R5A,ANXA2,AREG,BCL11A,CDKN1A,CERS2,DUSP6,EGFR,GSTP1,SLC2A1,HEY1,HSPA1A,IFI27,ISG15,JUN,PKM,MUC1,MYC,NFE2L2,RAB12,RHOA,RPS6,SOX2,TRIM16,YAP1,SLC25A5,AGR2,ANXA1,NET1,BAG3,HSPA5,ALCAM,CD44,CDKN2A,HSPD1,CLTC,CLU,CAPNS1,CTNND1,DDR1,DUSP1,EGR1,ERRFI1,EZR,FTL,GAPDH,GCLM,GCLC,GSR,HAX1,HBEGF,HSPA8,HK1,NFKBIA,ITGB1,ITGB8,TCF4,AK4,KLF4,LAMP2,LAMP3,LDHA,LRRFIP1,MTDH,NOTCH3,NQO1,NTRK2,TP63,PABPC1,PDCD10,PGK1,POMP,RAB27A,ERBB3,RND3,HNRNPA1,S100A11,TMED3,TMEM54,TNFSF10,TOP1,TUSC3,USP14,WNT5A,ENO1,SLC16A1,CALR,NPM1,CEBPD,DHCR24,GFPT1,INSIG1,BRD2,NKX2-1,FZD7,ALDH1A1
Irregularity in Drug Uptake and Drug Efflux3.30e-038.40e-0394537623467Malignant cellsSLC2A1,ABCC1,ABCE1,ABCG1,ABCC5,SLC34A2
Drug Inactivation by Structure Modification9.30e-021.60e-0194527323467Malignant cellsGSTP1,CES1,CMPK1
Aberration of the Drug's Therapeutic Target3.00e-013.70e-0194590523467Malignant cellsEGFR,CDKN2A,NPM1,NECTIN4,LRRK2
Epigenetic Alteration of DNA, RNA or Protein9.80e-019.80e-019454551123467Malignant cellsEGFR,H2AFY,LMNA,PMAIP1,CDKN2A,GAPDH,MALAT1,GDI2,PPP1R15A,MT-CO2,MX1

Enrichment results for 1 known drug resistance mechanisms in TME cells

boxplot
MechnismPvalFDRSignatureGenesetOverlapBackgroundCell typeEnriched Genes
Regulation by the Disease Microenvironment2.90e-012.90e-01239186323467B cellsPAK1,CXCR4,MALAT1
Regulation by the Disease Microenvironment1.80e-021.80e-02126186423467CD4+ T cellsCXCR4,JAK3,RHOB,VIM
Regulation by the Disease Microenvironment6.20e-026.20e-02114186323467CD8+ T cellsCXCR4,RHOB,VIM
Regulation by the Disease Microenvironment1.00e+001.00e+008186023467Endothelial cellsNA
Regulation by the Disease Microenvironment1.00e+001.00e+009186023467FibroblastsNA
Regulation by the Disease Microenvironment4.10e-024.10e-02238186523467Mono_MacroVEGFA,CXCR4,IL1B,SOCS3,MALAT1
Regulation by the Disease Microenvironment1.90e-021.90e-02193186523467NeutrophilsPTEN,IL1B,SOCS3,VIM,TIMP2
Regulation by the Disease Microenvironment3.00e-013.00e-0144186123467pDCsCXCR4
Regulation by the Disease Microenvironment2.30e-022.30e-0276186323467Plasma cellsTP53INP1,CXCR4,VIM

check buttonHallmark, KEGG and GOBP enrichment results for up-regulated genes in resistant group of post-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)
Up-regulated HallmarkUp-regulated KEGGUp-regulated GO BP
boxplotboxplotboxplot

check buttonHallmark, KEGG and GOBP enrichment results for down-regulated genes in resistant group of post-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)
Down-regulated HallmarkDown-regulated KEGGDown-regulated GO BP
boxplotboxplotboxplot

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Mechanism analysis of drug resistance-related DEGs for each cell type in one patient or cell lines

check buttonThis dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. Enrichment results for 5 known drug resistance mechanisms in malignant cells and 1 known mechanism in TME cells are shown here.The "Signature" column represents the differentially expressed genes (DEGs) used for enrichment. The "Geneset" column represents the genes included in this mechanism. The "Overlap" column represents the number of genes in the "Geneset" that are enriched in the "Signature". The "Enriched Genes" column represents the genes in the "Geneset" that are enriched in the "Signature". (If the image exists, the user can click on it to enlarge it in a new window.)

check buttonHallmark, KEGG and GOBP enrichment results for up-regulated genes in resistant group. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

check buttonHallmark, KEGG and GOBP enrichment results for down-regulated genes in resistant group. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

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MicroRNAs (miRNAs) regulating drug resistance-related DEGs for malignant cells

check buttonIn the pre-treatment samples, the miRNAs with a score greater than 80 that regulate the top10 abs(avg_log2FC) drug resistance-related DEGs for malignant cells are shown here. If the gene does not have any miRNAs with a score greater than 80, it will not be shown. Here only the names of miRNAs with a score greater than 90 are shown, but some names will not be shown because of too many overlaps. (Complete files containing all datasets and cell types can be downloaded from the download section.)

check buttonIn the post-treatment samples, the miRNAs with a score greater than 80 that regulate the top10 abs(avg_log2FC) drug resistance-related DEGs for Malignant cells are shown here. If the gene does not have any miRNAs with a score greater than 80, it will not be shown. Here only the names of miRNAs with a score greater than 90 are shown, but some names will not be shown because of too many overlaps. (Complete files containing all datasets and cell types can be downloaded from the download section.)
Regulating up-regulated DEGs in resistant groupRegulating down-regulated DEGs in resistant group
boxplotboxplot

check buttonThis dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. The miRNAs with a score greater than 80 that regulate the top10 abs(avg_log2FC) drug resistance-related DEGs for Malignant cells are shown here. Here only the names of miRNAs with a score greater than 80 are shown, but some names will not be shown because of too many overlaps. If the gene does not have any miRNAs with a score greater than 90, it will not be shown. (Complete files containing all datasets and cell types can be downloaded from the download section.)

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Motifs and transcription factors (TFs) regulating drug resistance-related DEGs for each cell type

check buttonIn the pre-treatment samples, the motifs and TFs that regulate drug resistance-related DEGs for each cell type are shown here. (Complete files can be downloaded from the download section.)

check buttonIn the post-treatment samples, the motifs and TFs that regulate drug resistance-related DEGs for each cell type are shown here. (Complete files can be downloaded from the download section.)
Motifs and TFs regulating up-regulated DEGs in resistant group of the post-treatment samples
motifmotifNESAUCTF_highConfCell_type
motifkznf__ZNF613_Imbeault2017_RP_RCADE5.970.16ZNF613 (directAnnotation). B cells
motifjaspar__MA1125.15.870.158ZNF384 (directAnnotation). B cells
motiftransfac_pro__M012505.020.138E2F1 (directAnnotation). B cells
motiftransfac_public__M004154.850.135ZEB1 (directAnnotation). B cells
motiftfdimers__MD001874.580.129GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation). B cells
motiftransfac_pro__M066784.430.125ZNF287 (inferredBy_Orthology). B cells
motiftaipale_tf_pairs__ELK1_FOXI1_RSCGGAANRWMAACAN_CAP_repr4.40.125ELK1; FOXI1 (directAnnotation). B cells
motifmetacluster_167.54.340.123EHF; ELF5; NFATC3; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIC; SPIC; STAT5A (directAnnotation). ETS1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIC (inferredBy_Orthology). B cells
motifmetacluster_130.24.150.119ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology). B cells
motifdbtfbs__GMEB1_K562_ENCSR928KOR_merged_N14.150.119GMEB1 (directAnnotation). B cells
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Motifs and TFs regulating down-regulated DEGs in resistant group of the post-treatment samples
motifmotifNESAUCTF_highConfCell_type
motifmetacluster_2.86.110.0846IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology). B cells
motifmetacluster_2.94.650.0704IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology). B cells
motifjaspar__MA1952.14.480.0688FOXJ2 (directAnnotation). B cells
motifmetacluster_2.64.020.0642IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology). B cells
motifmetacluster_113.44.010.0642MYB; MYB; MYBL1; MYBL2 (directAnnotation). MYB; MYB; MYBL1; MYBL2 (inferredBy_Orthology). B cells
motifjaspar__MA0776.13.950.0636MYBL1 (directAnnotation). B cells
motiftransfac_pro__M058033.750.0616ZNF584 (directAnnotation). B cells
motifmetacluster_22.213.60.0601NFE2L2 (inferredBy_Orthology). B cells
motiftfdimers__MD000073.560.0598E2F1; IRF8 (directAnnotation). B cells
motiftfdimers__MD001383.540.0595IRF1; IRF2; IRF3; IRF4; IRF5; IRF7; IRF8; IRF9; MYB (directAnnotation). B cells
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check buttonThis dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. Motifs and TFs that regulate drug resistance-related DEGs for each cell type are shown here. (Complete files can be downloaded from the download section.)

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Differentially expressed genes act as transcription factors

check buttonThis table shows the differentially expressed genes that act as transcription factors. (Complete files can be downloaded from the download section.)
TFmotifExpressionCell typeTimepoint

IRF7

metacluster_2.6downB cellspost

STAT1

metacluster_2.6downB cellspost

STAT2

metacluster_2.6downB cellspost

IRF7

tfdimers__MD00138downB cellspost

IRF7

metacluster_2.7downB cellspost

STAT1

metacluster_2.7downB cellspost

STAT2

metacluster_2.7downB cellspost

SPIB

metacluster_167.5downB cellspost

STAT1

cisbp__M11350downB cellspost

STAT1

tfdimers__MD00177downB cellspost
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