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	Dataset summary
	Drug summary
	Umap of single cell types and conditions (resistant and sensitive)
	Comparison of cell composition between the resistant and sensitive groups (This dataset does not contain this module)
	Comparison of intra-tumor heterogeneity (ITH) and epithelial-mesenchymal transition (EMT) scores of malignant cells between the resistant and sensitive groups
	Difference of cell-cell interactions between the resistant and sensitive groups (This dataset does not contain this module)
	Differentially expressed genes (DEGs) between the resistant and sensitive groups for each cell type
	Mechanism analysis of drug resistance-related DEGs for each cell type in the pre-treatment samples (This dataset does not contain this module)
	Mechanism analysis of drug resistance-related DEGs for each cell type in the post-treatment samples (This dataset does not contain this module)
	Mechanism analysis of drug resistance-related DEGs for each cell type in one patient or cell lines
	MicroRNAs (miRNAs) regulating drug resistance-related DEGs for Malignant cells
	Motifs and transcription factors (TFs) regulating drug resistance-related DEGs for each cell type
•	Differentially expressed genes act as transcription factors

Dataset: GSE164897_VemCob

Dataset summary for GSE164897_VemCob

Datast information	Dataset	GSE164897_VemCob
	PMID	34591417
	Raw data ID/link	PRJNA692421
	Organism	Homo sapiens
	Source	A375 cell line
	Tissue	Cell line
	Cancer type level1	Melanoma
	Cancer type level2	BRAFV600E-mutant melanoma
	Regimen	vemurafenib + combimetinib
	Drug type	Targeted therapy
	Sample size	resistant 1, sensitive 1
	Cell number	14851
	Extract protocol	10x genomics
	Data processing	CellRanger
	Public date	Public on Jan 16, 2021
	Description	This dataset has 1 cell line with a sensitive pre-treatment sample and a resistant post-treatment sample.

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Drug summary for GSE164897_VemCob

Drug name	DrugBank ID	Drug type	Targets name	Targets uniprot ID
"Vemurafenib"	DB08881	small molecule	BRAF	P15056
"combimetinib" is not included in the drug list.

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Umap of single cell types and conditions (resistant and sensitive)

Umap of cell types and conditions (resistant and sensitive). If this dataset has both pre-treatment and post-treatment samples, the cell types were annotated together. If this dataset is a cell line dataset, the UMAP of cell clusters and the cell ratio of drug-resistant and sensitive groups within each cluster will also be shown. (If the image exists, the user can click on it to enlarge it in a new window.)

Umap of cell types	Umap of conditions
Umap of cell clusters	Cell ratio of drug-resistant and sensitive groups within each cluster

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Comparison of cell composition between the resistant and sensitive groups

In the pre-treatment samples, the cell composition of the resistant and sensitive groups were compared.
* represents significant difference. (If the image exists, the user can click on it to enlarge it in a new window.)

In the post-treatment samples, the cell composition of the resistant and sensitive groups were compared.
* represents significant difference. (If the image exists, the user can click on it to enlarge it in a new window.)

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Comparison of ITH and EMT scores of malignant cells between the resistant and sensitive groups

Comparison of ITH (intra-tumoral heterogeneity) and EMT (epithelial-mesenchymal transition) scores of malignant cells between the resistant and sensitive groups. ITH represents intratumoral heterogeneity, EMT represents epithelial mesenchymal transition, pre represents pre-treatment, post represents post-treatment, post2 represents longer post-treatment. (If the image exists, the user can click on it to enlarge it in a new window.)

Comparison of ITH scores

Comparison of EMT scores

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Difference of cell-cell interactions between the resistant and sensitive groups

In the pre-treatment samples, the difference in cell-cell interactions between the resistant and sensitive groups was compared. The numbers indicate the count of cell-cell interactions that were either higher or lower in the resistant group compared to the sensitive group. The dot plots of significant ligand-receptor pairs in the resistant group and sensitive group are subsequently displayed. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

In the post-treatment samples, the difference in cell-cell interactions between the resistant and sensitive groups was compared. The numbers indicate the count of cell-cell interactions that were either higher or lower in the resistant group compared to the sensitive group. The dot plots of significant ligand-receptor pairs in the resistant group and sensitive group are subsequently displayed. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

This dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. The difference in cell-cell interactions between the resistant and sensitive groups was compared. The numbers indicate the count of cell-cell interactions that were either higher or lower in the resistant group compared to the sensitive group. The dot plots of significant ligand-receptor pairs in the resistant group and sensitive group are subsequently displayed. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

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Differentially expressed genes (DEGs) between the resistant and sensitive groups for each cell type

In the pre-treatment samples, the differentially expressed genes (|avg_log2FC|>0.25 & p_val_adj<0.05) between the resistant and sensitive groups for each cell type.

In the post-treatment samples, the differentially expressed genes (|avg_log2FC|>0.25 & p_val_adj<0.05) between the resistant and sensitive groups for each cell type.

This dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. The following are differentially expressed genes (|avg_log2FC|>0.25 & p_val_adj<0.05) between the resistant and sensitive groups for each cell type.

Gene symbol	Gene id	avg_log2FC	p_val	p_val_adj	pct.1	pct.2	Cell type	Timepoint
MEA1	ENSG00000124733	0.741019	0.00e+00	0.00e+00	0.747	0.535	Malignant cells	NA
COL3A1	ENSG00000168542	0.740425	0.00e+00	0.00e+00	0.289	0	Malignant cells	NA
VPS29	ENSG00000111237	0.73961	0.00e+00	0.00e+00	0.662	0.437	Malignant cells	NA
DKK1	ENSG00000107984	0.736856	0.00e+00	0.00e+00	0.379	0.143	Malignant cells	NA
DDX24	ENSG00000273761	0.736036	0.00e+00	0.00e+00	0.58	0.296	Malignant cells	NA
WDR83OS	ENSG00000105583	0.7342	0.00e+00	0.00e+00	0.987	0.917	Malignant cells	NA
BLOC1S1	ENSG00000135441	0.732556	0.00e+00	0.00e+00	0.809	0.614	Malignant cells	NA
MIR4435-2HG	ENSG00000172965	0.732499	0.00e+00	0.00e+00	0.552	0.256	Malignant cells	NA
ARL6IP1	ENSG00000170540	0.730402	0.00e+00	0.00e+00	0.446	0.155	Malignant cells	NA
ANP32E	ENSG00000143401	0.728256	0.00e+00	0.00e+00	0.557	0.283	Malignant cells	NA
RNF181	ENSG00000168894	0.727613	0.00e+00	0.00e+00	0.853	0.667	Malignant cells	NA
RBM8A	ENSG00000265241	0.726105	0.00e+00	0.00e+00	0.935	0.817	Malignant cells	NA
UBE2T	ENSG00000077152	0.724494	0.00e+00	0.00e+00	0.523	0.237	Malignant cells	NA
HSPA8	ENSG00000109971	0.723361	0.00e+00	0.00e+00	0.909	0.704	Malignant cells	NA
CKAP4	ENSG00000136026	0.723314	0.00e+00	0.00e+00	0.562	0.268	Malignant cells	NA
MRPL18	ENSG00000112110	0.722796	0.00e+00	0.00e+00	0.612	0.361	Malignant cells	NA
ARPC3	ENSG00000111229	0.721525	0.00e+00	0.00e+00	0.963	0.903	Malignant cells	NA
RAN	ENSG00000132341	0.718822	0.00e+00	0.00e+00	0.993	0.955	Malignant cells	NA
TMA7	ENSG00000232112	0.716252	0.00e+00	0.00e+00	1	1	Malignant cells	NA
BCAP31	ENSG00000185825	0.712938	0.00e+00	0.00e+00	0.836	0.659	Malignant cells	NA
TUBA1C	ENSG00000167553	0.712336	0.00e+00	0.00e+00	0.882	0.747	Malignant cells	NA
WFDC3	ENSG00000124116	0.710592	0.00e+00	0.00e+00	0.403	0.075	Malignant cells	NA
ITGA2	ENSG00000164171	0.709094	0.00e+00	0.00e+00	0.414	0.113	Malignant cells	NA
MT-ND1	ENSG00000198888	0.708276	0.00e+00	0.00e+00	1	0.999	Malignant cells	NA
SLIRP	ENSG00000119705	0.707678	0.00e+00	0.00e+00	0.996	0.978	Malignant cells	NA
SRSF7	ENSG00000115875	0.707559	0.00e+00	0.00e+00	0.845	0.639	Malignant cells	NA
UQCRQ	ENSG00000164405	0.705794	0.00e+00	0.00e+00	1	0.999	Malignant cells	NA
TMBIM4	ENSG00000155957	0.704562	0.00e+00	0.00e+00	0.549	0.258	Malignant cells	NA
SNRPF	ENSG00000139343	0.704461	0.00e+00	0.00e+00	0.964	0.894	Malignant cells	NA
LDHA	ENSG00000288299	0.702791	0.00e+00	0.00e+00	0.992	0.952	Malignant cells	NA
CCDC80	ENSG00000091986	0.701001	0.00e+00	0.00e+00	0.398	0.081	Malignant cells	NA
MED31	ENSG00000108590	0.698685	0.00e+00	0.00e+00	0.49	0.16	Malignant cells	NA
RPS27L	ENSG00000185088	0.69227	0.00e+00	0.00e+00	0.969	0.828	Malignant cells	NA
STMP1	ENSG00000243317	0.689771	0.00e+00	0.00e+00	0.837	0.659	Malignant cells	NA
COX4I1	ENSG00000131143	0.687516	0.00e+00	0.00e+00	1	0.999	Malignant cells	NA
MYL12A	ENSG00000101608	0.687447	0.00e+00	0.00e+00	0.786	0.597	Malignant cells	NA
NDUFA2	ENSG00000131495	0.686903	0.00e+00	0.00e+00	0.932	0.793	Malignant cells	NA
DCBLD2	ENSG00000057019	0.686606	0.00e+00	0.00e+00	0.654	0.464	Malignant cells	NA
POLR2H	ENSG00000163882	0.686076	0.00e+00	0.00e+00	0.674	0.488	Malignant cells	NA
SGK1	ENSG00000118515	0.678798	0.00e+00	0.00e+00	0.334	0.059	Malignant cells	NA
SF3B5	ENSG00000169976	0.67468	0.00e+00	0.00e+00	0.731	0.558	Malignant cells	NA
PFDN5	ENSG00000123349	0.67432	0.00e+00	0.00e+00	0.999	0.988	Malignant cells	NA
TMEM167A	ENSG00000174695	0.672593	0.00e+00	0.00e+00	0.745	0.563	Malignant cells	NA
HAS2	ENSG00000170961	0.671158	0.00e+00	0.00e+00	0.311	0.009	Malignant cells	NA
MORF4L1	ENSG00000185787	0.668896	0.00e+00	0.00e+00	0.821	0.66	Malignant cells	NA
PSENEN	ENSG00000205155	0.66217	0.00e+00	0.00e+00	0.573	0.322	Malignant cells	NA
CSAG1	ENSG00000198930	0.66144	0.00e+00	0.00e+00	0.807	0.654	Malignant cells	NA
PPP1CB	ENSG00000213639	0.655594	0.00e+00	0.00e+00	0.482	0.261	Malignant cells	NA
CHCHD7	ENSG00000170791	0.655157	0.00e+00	0.00e+00	0.567	0.332	Malignant cells	NA
VCL	ENSG00000035403	0.643338	0.00e+00	0.00e+00	0.428	0.144	Malignant cells	NA

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Mechanism analysis of drug resistance-related DEGs for each cell type in the pre-treatment samples

Enrichment results for 5 known drug-resistant mechanisms in malignant cells and 1 known mechanism in TME cells.The "Signature" column represents the differentially expressed genes (DEGs) used for enrichment. The "Geneset" column represents the genes included in this mechanism. The "Overlap" column represents the number of genes in the "Geneset" that are enriched in the "Signature". The "Enriched Genes" column represents the genes in the "Geneset" that are enriched in the "Signature". (If the image exists, the user can click on it to enlarge it in a new window.)

Hallmark, KEGG and GOBP enrichment results for up-regulated genes in resistant group of pre-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

Hallmark, KEGG and GOBP enrichment results for down-regulated genes in resistant group of pre-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window.Complete files can be downloaded from the download section.)

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Mechanism analysis of drug resistance-related DEGs for each cell type in the post-treatment samples

Enrichment results for 5 known drug resistance mechanisms in malignant cells and 1 known mechanism in TME cells.The "Signature" column represents the differentially expressed genes (DEGs) used for enrichment. The "Geneset" column represents the genes included in this mechanism. The "Overlap" column represents the number of genes in the "Geneset" that are enriched in the "Signature". The "Enriched Genes" column represents the genes in the "Geneset" that are enriched in the "Signature". (If the image exists, the user can click on it to enlarge it in a new window.)

Hallmark, KEGG and GOBP enrichment results for up-regulated genes in resistant group of post-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

Hallmark, KEGG and GOBP enrichment results for down-regulated genes in resistant group of post-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

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Mechanism analysis of drug resistance-related DEGs for each cell type in one patient or cell lines

This dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. Enrichment results for 5 known drug resistance mechanisms in malignant cells and 1 known mechanism in TME cells are shown here.The "Signature" column represents the differentially expressed genes (DEGs) used for enrichment. The "Geneset" column represents the genes included in this mechanism. The "Overlap" column represents the number of genes in the "Geneset" that are enriched in the "Signature". The "Enriched Genes" column represents the genes in the "Geneset" that are enriched in the "Signature". (If the image exists, the user can click on it to enlarge it in a new window.)

Enrichment results for 5 known drug resistance mechanisms in malignant cells

Mechnism	Pval	FDR	Signature	Geneset	Overlap	Background	Cell type	Enriched Genes
Unusual Activation of Pro-survival Pathway	2.90e-07	1.50e-06	1733	781	97	23467	Malignant cells	AURKA,BAX,BRCA1,CDCP1,CDK4,COL3A1,CTNNB1,DCTD,DNMT1,GSTP1,HMGA1,HMGB1,ID1,IRS1,PKM,MCL1,MAP1LC3B,NFE2L2,NFKB1,PARP1,RPS6,S100A4,SHC1,ST3GAL4,SOX4,PBK,YWHAZ,AAMDC,SLC25A5,ATG3,BAD,BAG1,BID,HSPA5,BRD4,BTG1,CCNB1,CDK1,CCND1,CD44,DDIT3,DKK1,EGR1,ERCC1,ERRFI1,FIS1,FOXM1,FTL,FUS,GAPDH,HDAC3,HMGB2,HSPA8,HSPB1,IL24,CXCL8,NKIRAS2,LDHA,MTDH,MGMT,SPP1,PABPC1,PGK1,AGPAT2,POMP,PRKDC,PSMB5,PSMG2,PTPN12,RAC1,RAP1B,ERBB3,HNRNPA1,RSF1,S100A11,SDHB,SMC4,SMUG1,SOX10,TPT1,TFAM,TGFA,TMED3,TMEM54,TOP1,WNT5A,YEATS4,MAGEA4,CALR,NPM1,EIF4EBP1,MDK,RCN1,PMVK,EBP,TRIB3,BIRC2
Drug Inactivation by Structure Modification	3.20e-01	8.00e-01	1733	27	3	23467	Malignant cells	GSTP1,GSS,NME1
Aberration of the Drug's Therapeutic Target	6.60e-01	9.60e-01	1733	90	6	23467	Malignant cells	BRCA1,CDK4,NPM1,COMT,AKR1B1,TOP2A
Irregularity in Drug Uptake and Drug Efflux	7.70e-01	9.60e-01	1733	37	2	23467	Malignant cells	SLC3A2,SLC7A5
Epigenetic Alteration of DNA, RNA or Protein	1.00e+00	1.00e+00	1733	455	14	23467	Malignant cells	DNMT1,IRS1,LMNA,TRIP6,PMAIP1,GAPDH,CXCL8,SMC4,TIMP1,CYTOR,MALAT1,GIHCG,GDI2,PPP1R15A

Hallmark, KEGG and GOBP enrichment results for up-regulated genes in resistant group. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

Up-regulated Hallmark	Up-regulated KEGG	Up-regulated GO BP

Hallmark, KEGG and GOBP enrichment results for down-regulated genes in resistant group. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

Down-regulated Hallmark	Down-regulated KEGG	Down-regulated GO BP

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MicroRNAs (miRNAs) regulating drug resistance-related DEGs for malignant cells

In the pre-treatment samples, the miRNAs with a score greater than 80 that regulate the top10 abs(avg_log2FC) drug resistance-related DEGs for malignant cells are shown here. If the gene does not have any miRNAs with a score greater than 80, it will not be shown. Here only the names of miRNAs with a score greater than 90 are shown, but some names will not be shown because of too many overlaps. (Complete files containing all datasets and cell types can be downloaded from the download section.)

In the post-treatment samples, the miRNAs with a score greater than 80 that regulate the top10 abs(avg_log2FC) drug resistance-related DEGs for Malignant cells are shown here. If the gene does not have any miRNAs with a score greater than 80, it will not be shown. Here only the names of miRNAs with a score greater than 90 are shown, but some names will not be shown because of too many overlaps. (Complete files containing all datasets and cell types can be downloaded from the download section.)

This dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. The miRNAs with a score greater than 80 that regulate the top10 abs(avg_log2FC) drug resistance-related DEGs for Malignant cells are shown here. Here only the names of miRNAs with a score greater than 80 are shown, but some names will not be shown because of too many overlaps. If the gene does not have any miRNAs with a score greater than 90, it will not be shown. (Complete files containing all datasets and cell types can be downloaded from the download section.)

Regulating up-regulated DEGs in resistant group	Regulating down-regulated DEGs in resistant group

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Motifs and transcription factors (TFs) regulating drug resistance-related DEGs for each cell type

In the pre-treatment samples, the motifs and TFs that regulate drug resistance-related DEGs for each cell type are shown here. (Complete files can be downloaded from the download section.)

In the post-treatment samples, the motifs and TFs that regulate drug resistance-related DEGs for each cell type are shown here. (Complete files can be downloaded from the download section.)

This dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. Motifs and TFs that regulate drug resistance-related DEGs for each cell type are shown here. (Complete files can be downloaded from the download section.)

Motifs and TFs regulating up-regulated DEGs in resistant group

motif	motif	NES	AUC	TF_highConf	Cell_type
	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	6.81	0.0742	ETV5; HOXA2 (directAnnotation).	Malignant cells
	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	6.77	0.0739	ETS2 (directAnnotation).	Malignant cells
	swissregulon__hs__ETV6	6.69	0.0732	ETV6 (directAnnotation).	Malignant cells
	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	6.6	0.0725	ELK1; HOXA1 (directAnnotation).	Malignant cells
	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	6.03	0.0681	ELF1; MEIS1 (directAnnotation).	Malignant cells
	jaspar__MA1483.2	5.98	0.0677	ELF2 (directAnnotation).	Malignant cells
	hdpi__TP73	5.98	0.0677	TP73 (directAnnotation).	Malignant cells
	metacluster_191.2	5.71	0.0656	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).	Malignant cells
	swissregulon__hs__ELF2	5.57	0.0645	ELF2 (directAnnotation).	Malignant cells
	metacluster_191.3	5.52	0.0641	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).	Malignant cells

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Motifs and TFs regulating down-regulated DEGs in resistant group

motif	motif	NES	AUC	TF_highConf	Cell_type
	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	8.96	0.0694	ETS2 (directAnnotation).	Malignant cells
	transfac_pro__M04826	7.72	0.0628	EP300 (directAnnotation).	Malignant cells
	metacluster_166.2	6.63	0.057	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).	Malignant cells
	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	6.55	0.0566	ETV5; FOXI1 (directAnnotation).	Malignant cells
	metacluster_191.3	6.5	0.0563	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).	Malignant cells
	jaspar__MA1483.2	6.36	0.0556	ELF2 (directAnnotation).	Malignant cells
	metacluster_191.2	6.34	0.0555	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).	Malignant cells
	metacluster_34.4	6.2	0.0547	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).	Malignant cells
	hdpi__FLI1	6.15	0.0545	FLI1 (directAnnotation).	Malignant cells
	metacluster_166.4	6.11	0.0543	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).	Malignant cells

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Differentially expressed genes act as transcription factors

This table shows the differentially expressed genes that act as transcription factors. (Complete files can be downloaded from the download section.)

TF	motif	Expression	Cell type	Timepoint
EGR1	metacluster_34.3	up	Malignant cells	NA
ETV4	metacluster_166.2	down	Malignant cells	NA
ETV4	metacluster_191.3	down	Malignant cells	NA
ETV4	metacluster_166.4	down	Malignant cells	NA
GABPB1	metacluster_166.4	down	Malignant cells	NA
ETV4	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	down	Malignant cells	NA
ETV4	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	down	Malignant cells	NA
ETV4	hdpi__ETV4	down	Malignant cells	NA
ETV4	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	down	Malignant cells	NA
ETV4	metacluster_138.2	down	Malignant cells	NA

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."