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Center for Computational Systems Medicine
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Dataset summary

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Drug summary

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Umap of single cell types and conditions (resistant and sensitive)

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Comparison of cell composition between the resistant and sensitive groups (This dataset does not contain this module)

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Comparison of intra-tumor heterogeneity (ITH) and epithelial-mesenchymal transition (EMT) scores of malignant cells between the resistant and sensitive groups

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Difference of cell-cell interactions between the resistant and sensitive groups (This dataset does not contain this module)

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Differentially expressed genes (DEGs) between the resistant and sensitive groups for each cell type

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Mechanism analysis of drug resistance-related DEGs for each cell type in the pre-treatment samples (This dataset does not contain this module)

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Mechanism analysis of drug resistance-related DEGs for each cell type in the post-treatment samples (This dataset does not contain this module)

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Mechanism analysis of drug resistance-related DEGs for each cell type in one patient or cell lines

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MicroRNAs (miRNAs) regulating drug resistance-related DEGs for Malignant cells

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Motifs and transcription factors (TFs) regulating drug resistance-related DEGs for each cell type

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Differentially expressed genes act as transcription factors

Dataset: GSE131984_JQ1Pac

Dataset summary for GSE131984_JQ1Pac

Datast informationDatasetGSE131984_JQ1Pac
PMID32393766
Raw data ID/linkPRJNA545508
OrganismHomo sapiens
SourceSUM159 cell line
TissueCell line
Cancer type level1Breast cancer
Cancer type level2Triple-negative breast cancer (TNBC)
RegimenJQ1 + paclitaxel
Drug typeTargeted therapy
Sample sizeresistant 1, sensitive 2
Cell number1704
Extract protocol10x genomics
Data processingCellRanger 2.1.0
Public datePublic on Apr 08, 2023
DescriptionThis dataset has 1 cell line with 2 sensitive pre-treatment samples and 1 resistant post-treatment sample.

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Drug summary for GSE131984_JQ1Pac

Drug nameDrugBank IDDrug typeTargets nameTargets uniprot ID
"JQ1" is not included in the drug list.
"Paclitaxel"

DB01229

small moleculeTUBB1; BCL2; MAP4; MAP2; MAPT; NR1I2Q9H4B7; P10415; P27816; P11137; P10636; O75469

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Umap of single cell types and conditions (resistant and sensitive)

check buttonUmap of cell types and conditions (resistant and sensitive). If this dataset has both pre-treatment and post-treatment samples, the cell types were annotated together. If this dataset is a cell line dataset, the UMAP of cell clusters and the cell ratio of drug-resistant and sensitive groups within each cluster will also be shown. (If the image exists, the user can click on it to enlarge it in a new window.)
Umap of cell typesboxplotUmap of conditionsboxplot
Umap of cell clustersboxplotCell ratio of drug-resistant and sensitive groups within each clusterboxplot

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Comparison of cell composition between the resistant and sensitive groups

check buttonIn the pre-treatment samples, the cell composition of the resistant and sensitive groups were compared.
* represents significant difference.
(If the image exists, the user can click on it to enlarge it in a new window.)

check buttonIn the post-treatment samples, the cell composition of the resistant and sensitive groups were compared.
* represents significant difference.
(If the image exists, the user can click on it to enlarge it in a new window.)

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Comparison of ITH and EMT scores of malignant cells between the resistant and sensitive groups

check buttonComparison of ITH (intra-tumoral heterogeneity) and EMT (epithelial-mesenchymal transition) scores of malignant cells between the resistant and sensitive groups. ITH represents intratumoral heterogeneity, EMT represents epithelial mesenchymal transition, pre represents pre-treatment, post represents post-treatment, post2 represents longer post-treatment. (If the image exists, the user can click on it to enlarge it in a new window.)
Comparison of ITH scoresboxplotComparison of EMT scoresboxplot

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Difference of cell-cell interactions between the resistant and sensitive groups

check buttonIn the pre-treatment samples, the difference in cell-cell interactions between the resistant and sensitive groups was compared. The numbers indicate the count of cell-cell interactions that were either higher or lower in the resistant group compared to the sensitive group. The dot plots of significant ligand-receptor pairs in the resistant group and sensitive group are subsequently displayed. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

check buttonIn the post-treatment samples, the difference in cell-cell interactions between the resistant and sensitive groups was compared. The numbers indicate the count of cell-cell interactions that were either higher or lower in the resistant group compared to the sensitive group. The dot plots of significant ligand-receptor pairs in the resistant group and sensitive group are subsequently displayed. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

check buttonThis dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. The difference in cell-cell interactions between the resistant and sensitive groups was compared. The numbers indicate the count of cell-cell interactions that were either higher or lower in the resistant group compared to the sensitive group. The dot plots of significant ligand-receptor pairs in the resistant group and sensitive group are subsequently displayed. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

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Differentially expressed genes (DEGs) between the resistant and sensitive groups for each cell type

check buttonIn the pre-treatment samples, the differentially expressed genes (|avg_log2FC|>0.25 & p_val_adj<0.05) between the resistant and sensitive groups for each cell type.

check buttonIn the post-treatment samples, the differentially expressed genes (|avg_log2FC|>0.25 & p_val_adj<0.05) between the resistant and sensitive groups for each cell type.

check buttonThis dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. The following are differentially expressed genes (|avg_log2FC|>0.25 & p_val_adj<0.05) between the resistant and sensitive groups for each cell type.
Gene symbolGene idavg_log2FCp_valp_val_adjpct.1pct.2Cell typeTimepoint

EIF6

ENSG00000242372-0.6229470.00e+001.40e-450.8510.944Malignant cellsNA

SRSF2

ENSG00000161547-0.623090.00e+000.00e+000.9420.992Malignant cellsNA

SULT1B1

ENSG00000173597-0.6231067.99e-441.23e-390.0650.365Malignant cellsNA

KPNA2

ENSG00000182481-0.624779.86e-301.52e-250.6660.86Malignant cellsNA

TIMM13

ENSG00000099800-0.6251530.00e+000.00e+000.9660.999Malignant cellsNA

MRPL23

ENSG00000288141-0.6261350.00e+000.00e+000.9891Malignant cellsNA

HPRT1

ENSG00000165704-0.6267724.75e-397.32e-350.630.815Malignant cellsNA

C3orf14

ENSG00000114405-0.6267960.00e+000.00e+000.7280.928Malignant cellsNA

PRELID1

ENSG00000169230-0.6272730.00e+000.00e+0011Malignant cellsNA

MRPS18C

ENSG00000163319-0.6283380.00e+001.09e-420.7870.926Malignant cellsNA

UPF3B

ENSG00000125351-0.6288135.30e-428.17e-380.3420.64Malignant cellsNA

MAGEA12

ENSG00000213401-0.6293839.67e-411.49e-360.4070.702Malignant cellsNA

CCNA2

ENSG00000145386-0.6299221.42e-322.19e-280.2940.582Malignant cellsNA

EEF1E1

ENSG00000124802-0.6302594.20e-457.18e-410.750.895Malignant cellsNA

C20orf24

NA-0.6305510.00e+000.00e+000.7480.919Malignant cellsNA

RPS19BP1

ENSG00000187051-0.6308970.00e+000.00e+000.9330.979Malignant cellsNA

CTSL

ENSG00000135047-0.6314643.40e-315.24e-270.4030.644Malignant cellsNA

CDC123

ENSG00000151465-0.6368693.85e-375.93e-330.6690.849Malignant cellsNA

SNRPC

ENSG00000124562-0.6374080.00e+000.00e+000.8130.959Malignant cellsNA

SELK

NA-0.6374610.00e+000.00e+000.8480.97Malignant cellsNA

CISD1

ENSG00000122873-0.6387010.00e+000.00e+000.8160.962Malignant cellsNA

GLIPR1

ENSG00000139278-0.638717.93e-421.22e-370.4040.692Malignant cellsNA

NAA20

ENSG00000173418-0.6402380.00e+000.00e+000.8290.947Malignant cellsNA

UROD

ENSG00000126088-0.6404143.18e-434.90e-390.4350.711Malignant cellsNA

PLEK2

ENSG00000100558-0.6405961.40e-452.05e-410.4010.696Malignant cellsNA

MRPL13

ENSG00000172172-0.6418827.87e-391.21e-340.6390.825Malignant cellsNA

PSMB5

ENSG00000100804-0.6446260.00e+000.00e+000.9580.992Malignant cellsNA

JTB

ENSG00000143543-0.6460430.00e+000.00e+000.9720.997Malignant cellsNA

ACOT9

ENSG00000123130-0.6476229.15e-431.41e-380.3510.662Malignant cellsNA

UBE2T

ENSG00000077152-0.6485542.25e-383.47e-340.4710.748Malignant cellsNA

IFI27

ENSG00000275214-0.6493250.00e+000.00e+000.460.833Malignant cellsNA

PRPS2

ENSG00000101911-0.6497540.00e+000.00e+000.2270.598Malignant cellsNA

HDGF

ENSG00000143321-0.6497630.00e+000.00e+000.8180.946Malignant cellsNA

PRR13

ENSG00000205352-0.6505320.00e+000.00e+000.9130.992Malignant cellsNA

TMEM167A

ENSG00000174695-0.6530090.00e+000.00e+000.8820.984Malignant cellsNA

SRSF7

ENSG00000115875-0.6540230.00e+009.81e-450.9140.973Malignant cellsNA

UBE2S

ENSG00000108106-0.6549330.00e+007.57e-440.9740.998Malignant cellsNA

MRPL52

ENSG00000172590-0.6550650.00e+000.00e+000.820.96Malignant cellsNA

HNRNPDL

ENSG00000152795-0.6566370.00e+000.00e+000.970.996Malignant cellsNA

NXT1

ENSG00000132661-0.659310.00e+001.40e-440.5330.813Malignant cellsNA

TARS

NA-0.6599360.00e+000.00e+000.6770.867Malignant cellsNA

LSM5

ENSG00000106355-0.6603290.00e+000.00e+000.9690.997Malignant cellsNA

AP1S1

ENSG00000106367-0.6630120.00e+000.00e+000.6170.847Malignant cellsNA

VDAC1

ENSG00000213585-0.6632330.00e+000.00e+000.9810.999Malignant cellsNA

MRPL12

ENSG00000262814-0.6653410.00e+000.00e+000.9640.992Malignant cellsNA

NUPR1

ENSG00000176046-0.6657591.04e-371.60e-330.1010.383Malignant cellsNA

PBDC1

ENSG00000102390-0.6679712.12e-393.26e-350.3730.649Malignant cellsNA

SLC3A2

ENSG00000168003-0.6686231.89e-252.91e-210.4090.63Malignant cellsNA

NUCB2

ENSG00000070081-0.6691273.37e-385.19e-340.5010.731Malignant cellsNA

ISOC2

ENSG00000063241-0.6696070.00e+000.00e+000.5290.792Malignant cellsNA
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Mechanism analysis of drug resistance-related DEGs for each cell type in the pre-treatment samples

check buttonEnrichment results for 5 known drug-resistant mechanisms in malignant cells and 1 known mechanism in TME cells.The "Signature" column represents the differentially expressed genes (DEGs) used for enrichment. The "Geneset" column represents the genes included in this mechanism. The "Overlap" column represents the number of genes in the "Geneset" that are enriched in the "Signature". The "Enriched Genes" column represents the genes in the "Geneset" that are enriched in the "Signature". (If the image exists, the user can click on it to enlarge it in a new window.)

check buttonHallmark, KEGG and GOBP enrichment results for up-regulated genes in resistant group of pre-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

check buttonHallmark, KEGG and GOBP enrichment results for down-regulated genes in resistant group of pre-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window.Complete files can be downloaded from the download section.)

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Mechanism analysis of drug resistance-related DEGs for each cell type in the post-treatment samples

check buttonEnrichment results for 5 known drug resistance mechanisms in malignant cells and 1 known mechanism in TME cells.The "Signature" column represents the differentially expressed genes (DEGs) used for enrichment. The "Geneset" column represents the genes included in this mechanism. The "Overlap" column represents the number of genes in the "Geneset" that are enriched in the "Signature". The "Enriched Genes" column represents the genes in the "Geneset" that are enriched in the "Signature". (If the image exists, the user can click on it to enlarge it in a new window.)

check buttonHallmark, KEGG and GOBP enrichment results for up-regulated genes in resistant group of post-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

check buttonHallmark, KEGG and GOBP enrichment results for down-regulated genes in resistant group of post-treatment samples. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)

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Mechanism analysis of drug resistance-related DEGs for each cell type in one patient or cell lines

check buttonThis dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. Enrichment results for 5 known drug resistance mechanisms in malignant cells and 1 known mechanism in TME cells are shown here.The "Signature" column represents the differentially expressed genes (DEGs) used for enrichment. The "Geneset" column represents the genes included in this mechanism. The "Overlap" column represents the number of genes in the "Geneset" that are enriched in the "Signature". The "Enriched Genes" column represents the genes in the "Geneset" that are enriched in the "Signature". (If the image exists, the user can click on it to enlarge it in a new window.)
Enrichment results for 5 known drug resistance mechanisms in malignant cells
boxplot
MechnismPvalFDRSignatureGenesetOverlapBackgroundCell typeEnriched Genes
Unusual Activation of Pro-survival Pathway3.30e-161.70e-15194978113423467Malignant cellsATG5,AURKA,BAX,BCAT1,BIRC5,CTSL,CDCP1,CDK4,CDKN1A,CERS2,CFLAR,CIAPIN1,DCTD,FADD,HMGA1,HMGB1,ID1,IFI27,IL6,ISG15,MAGEA6,MAGEA12,MCL1,MYC,PDGFRA,PPARG,SHC1,ST3GAL4,SOX4,SOX9,SPRY2,STMN1,TGFB1,PBK,TYMS,VOPP1,XIAP,SLC25A5,AIFM1,AKAP12,AR,ANXA1,ATG3,BAD,BAG1,BID,HSPA5,BRD7,CASP1,CAV2,CCNA2,CCNB1,CDK1,HSPD1,COL1A1,CRIM1,DKK1,EGR1,EIF3A,HSP90B1,EZH2,EZR,FN1,FTL,GAPDH,G6PD,GAS6,GRB2,GCLM,HAX1,HMGN5,HNRNPU,EIF4A3,EIF4E,NFKBIA,IL18,KLF4,RPS6KA3,LAMP2,LDHA,LRRFIP1,MTDH,MXD4,MAGEA3,MAPK3,MAP2K2,MYBL2,IKBKG,NQO1,PIK3R1,PDCD10,PGK1,AGPAT2,PLK1,POMP,PSMB5,RAP1B,HRAS,NRAS,RAB27A,RRM1,RND3,S100A11,SDHB,SIAH2,SMC4,SOD2,SRSF2,TPT1,TFAM,TMED3,TNFAIP3,YY1,UBE2C,AXL,WLS,ENO1,IDH3A,GNAS,CD33,ARAF,NPM1,IL7R,EIF4EBP1,IDI1,RCN1,RELB,SQLE,PMVK,EBP,NUPR1,TRIB3,WTAP,ACAT2
Irregularity in Drug Uptake and Drug Efflux8.20e-022.10e-01194937623467Malignant cellsSLC3A2,ABCF2,ABCE1,SLC7A5,TAP1,SLC7A11
Drug Inactivation by Structure Modification1.80e-013.00e-01194927423467Malignant cellsCES1,SOD2,CDA,NME1
Aberration of the Drug's Therapeutic Target4.70e-015.90e-01194990823467Malignant cellsCDK4,PDGFRA,AR,EZH2,MAP2K2,NPM1,COMT,AKR1B1
Epigenetic Alteration of DNA, RNA or Protein1.00e+001.00e+0019494551723467Malignant cellsATG5,H2AFY,IL6,PPARG,SPRY2,TRIP6,TYMS,XIAP,PMAIP1,EZH2,GAPDH,MAPK3,SMC4,TIMP1,MALAT1,GDI2,PPP1R15A


check buttonHallmark, KEGG and GOBP enrichment results for up-regulated genes in resistant group. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)
Up-regulated HallmarkUp-regulated KEGGUp-regulated GO BP

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check buttonHallmark, KEGG and GOBP enrichment results for down-regulated genes in resistant group. Only show the top 50 pathways with fdr<0.05. If certain cell types are not displayed, it means that there are no significant pathways based on DEGs in those cell types. (If the image exists, the user can click on it to enlarge it in a new window. Complete files can be downloaded from the download section.)
Down-regulated HallmarkDown-regulated KEGGDown-regulated GO BP

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boxplot

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MicroRNAs (miRNAs) regulating drug resistance-related DEGs for malignant cells

check buttonIn the pre-treatment samples, the miRNAs with a score greater than 80 that regulate the top10 abs(avg_log2FC) drug resistance-related DEGs for malignant cells are shown here. If the gene does not have any miRNAs with a score greater than 80, it will not be shown. Here only the names of miRNAs with a score greater than 90 are shown, but some names will not be shown because of too many overlaps. (Complete files containing all datasets and cell types can be downloaded from the download section.)

check buttonIn the post-treatment samples, the miRNAs with a score greater than 80 that regulate the top10 abs(avg_log2FC) drug resistance-related DEGs for Malignant cells are shown here. If the gene does not have any miRNAs with a score greater than 80, it will not be shown. Here only the names of miRNAs with a score greater than 90 are shown, but some names will not be shown because of too many overlaps. (Complete files containing all datasets and cell types can be downloaded from the download section.)

check buttonThis dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. The miRNAs with a score greater than 80 that regulate the top10 abs(avg_log2FC) drug resistance-related DEGs for Malignant cells are shown here. Here only the names of miRNAs with a score greater than 80 are shown, but some names will not be shown because of too many overlaps. If the gene does not have any miRNAs with a score greater than 90, it will not be shown. (Complete files containing all datasets and cell types can be downloaded from the download section.)
Regulating up-regulated DEGs in resistant groupRegulating down-regulated DEGs in resistant group
boxplotboxplot

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Motifs and transcription factors (TFs) regulating drug resistance-related DEGs for each cell type

check buttonIn the pre-treatment samples, the motifs and TFs that regulate drug resistance-related DEGs for each cell type are shown here. (Complete files can be downloaded from the download section.)

check buttonIn the post-treatment samples, the motifs and TFs that regulate drug resistance-related DEGs for each cell type are shown here. (Complete files can be downloaded from the download section.)

check buttonThis dataset only has one patient or is a cell line dataset, the resistant sample is the post-treatment sample and the sensitive sample is the pre-treatment sample. Motifs and TFs that regulate drug resistance-related DEGs for each cell type are shown here. (Complete files can be downloaded from the download section.)
Motifs and TFs regulating up-regulated DEGs in resistant group
motifmotifNESAUCTF_highConfCell_type
motiftransfac_pro__M059934.650.0734ZNF711 (directAnnotation). Malignant cells
motifhocomoco__FOXP1_HUMAN.H11MO.0.A4.350.0706FOXP1 (directAnnotation). Malignant cells
motifmetacluster_22.164.220.0692BACH2 (directAnnotation). Malignant cells
motifmetacluster_22.124.150.0686NFE2; NFE2L1 (directAnnotation). Malignant cells
motifmetacluster_22.254.070.0678NFE2L2 (directAnnotation). Malignant cells
motifmetacluster_22.133.970.0668MAFK (inferredBy_Orthology). Malignant cells
motifmetacluster_22.173.840.0655NFE2 (directAnnotation). Malignant cells
motifmetacluster_22.113.830.0655NFE2 (directAnnotation). Malignant cells
motifmetacluster_22.193.830.0654NFE2 (directAnnotation). Malignant cells
motifmetacluster_22.203.80.0651MAFG (directAnnotation). Malignant cells
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Motifs and TFs regulating down-regulated DEGs in resistant group
motifmotifNESAUCTF_highConfCell_type
motiftaipale_tf_pairs__ETS2_RCCGGAAGTG_HT7.250.0649ETS2 (directAnnotation). Malignant cells
motifmetacluster_191.36.860.0627EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology). Malignant cells
motifmetacluster_166.46.40.0601BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology). Malignant cells
motifmetacluster_191.26.150.0587ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology). Malignant cells
motiftaipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP5.990.0577ELK3; FOXO1 (directAnnotation). Malignant cells
motiftaipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP5.730.0563ETV5; HOXA2 (directAnnotation). Malignant cells
motifjaspar__MA1483.25.620.0557ELF2 (directAnnotation). Malignant cells
motifmetacluster_166.25.520.0551ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology). Malignant cells
motiftransfac_pro__M048265.320.054EP300 (directAnnotation). Malignant cells
motiftaipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr5.30.0538ELF1; MEIS1 (directAnnotation). Malignant cells
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Differentially expressed genes act as transcription factors

check buttonThis table shows the differentially expressed genes that act as transcription factors. (Complete files can be downloaded from the download section.)
TFmotifExpressionCell typeTimepoint

ETS2

taipale_tf_pairs__ETS2_RCCGGAAGTG_HTdownMalignant cellsNA

ETS2

metacluster_191.3downMalignant cellsNA

ETV4

metacluster_191.3downMalignant cellsNA

ETV4

metacluster_166.4downMalignant cellsNA

ETV4

metacluster_166.2downMalignant cellsNA

ETS2

metacluster_138.2downMalignant cellsNA

ETV4

metacluster_138.2downMalignant cellsNA

ETV4

hdpi__ETV4downMalignant cellsNA

ZNF385D

taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_methdownMalignant cellsNA

ETV4

taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAPdownMalignant cellsNA
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."