This database is called CRISPRoffT, and the full name is 'CRISPR/Cas Off-Target Integrated Database'. The icon on the left side of the image depicts a CRISPR/Cas guide sequence being matched to a DNA sequence and then cutting both DNA strands. Because there is a mismatch, CRISPR/Cas DNA editing technology produces off-targets. The right side of the image shows the database name and full name.

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check002.gifOverview of CRISPRoffT Here is an schematic overview of this database. This image shows why CRISPR/Cas off-targets exist, where the data came from, what modules are included in this database, and what we have done with this database. The upper part of the image shows that the CRISPR/Cas DNA editing techonolgy produces off-targets due to sequence mismatches. We collected data from PubMed Central. In the middle of the image is CRISPRoffT, the name of the database. Below the database name is a section with 5 bulleted lists. The first list is titled 'Search By', with 4 bullet points: 'Guide Sequence', 'Gene Symbol', 'Target Sequence', and 'Target Region'. The second list is titled 'Browse By', with 3 bullet points: 'Source', 'Technology', 'Cas enzyme and guide RNA combination'. The third list is titled 'Statistics', with 1 bullet points: 'Summary of data'. The fourth list is titled 'Download', with 1 bullet points: 'Table of data'. The fifth list is titled 'Analysis', with 3 bullet points:'Comparison of potential off-target data', 'Comparison of validated off-target data', and 'Summary of each search or browse'.