IPAfunc logo - IPAfunc is a knowledgebase for functional annotations of intronic polyadenylation in human cancers. CAFuncIpA reveals the IpA events associated with cancer survival and tumor progression. Moreover, the potential downstream effects of IpA on gene/isoform expression, regulation of miRNAs, RNA binding proteins (RBPs), and alternative splicing events are included in CAFuncIpA. In addition, CAFuncIpA also reveals the upregulators of IpA events, such as the effects of genetic variants on intronic poly(A) sites and RBPs, as well as the effect of methylation phenotypes on IpA events.

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check002.gifOverview of IPAfunc.
overview figure of IPAfunc - IPAfunc is designed to provide functional annotations of intronic polyadenylation and fully comprehend the upstream regulatory factors, downstream effects, and clinical relevance of IpA events across pan-cancer types. Based on three major databases (TCGA, CPTAC, and CCLE), CAFuncIpA reveals the IpA events associated with cancer survival and tumor progression. Moreover, the potential downstream effects of IpA on gene/isoform expression, regulation of miRNAs, RNA binding proteins (RBPs), and alternative splicing events are included in CAFuncIpA. In addition, CAFuncIpA also reveals the upregulators of IpA events, such as the effects of genetic variants on intronic poly(A) sites and RBPs, as well as the effect of methylation phenotypes on IpA events.
check002.gifThe number of differential IpA events between tumor and normal.
The number of differential IpA events between tumor and normal - An image showing the number of differential IpA events and genes of 31 cancer types.
check002.gifThe number of associated IpA and isoforms in cancers.
The number of associated IpA and isoforms in cancers. - An image showing the number of associated IpA events and differential genes of 30 cancer types.
check002.gifThe number of associated IpA and genes in cancers.
The number of associated IpA and genes in cancers. - An image showing the number of associated IpA events and differential genes of 31 cancer types.
check002.gifThe number of IpA events associated with overall survival.
The number of IpA events associated with overall survival - An image showing the number of IpA events and differential genes of 31 cancer types across tumor stages.
check002.gifThe number of RBPs affected by IpA events.
The number of RBPs affected by IpA events - An image showing the number of RBPs affected by IpA events of 31 cancer types.
check002.gifThe number of IpA events affecting alternative splicing.
The number of IpA events affecting alternative splicing - An image showing the the number of IPAs that affect alternative splicing across 31 cancer types.