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lncRNA: ENSG00000281404

Summary for LINC01176

Gene summary

Gene information	Ensembl ID	ENSG00000281404
	Gene symbol	LINC01176
	Gene name	long intergenic non-protein coding RNA 1176
	HGNC	49548
	Entrez ID	100506516
	Gene type	lincRNA
	Synonyms	07p14.3\|LINC01176
	UniProtAcc

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Structure and expression level for LINC01176

AS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.

Differentially expressed gene analysis between cancer and normal samples.

Ensembl ID	Base mean	log2FC(AD/control)	lfcSE	Stat	P-value	Adjc.p-value	DEG direction	Cancer type
ENSG00000281404	1.092061e+02	1.217194e+00	1.367608e-01	8.900168e+00	5.580000e-19	7.300000e-18	UP	THCA
ENSG00000281404	9.006117e+01	1.905809e+00	1.459204e-01	1.306061e+01	5.530000e-39	8.500000e-38	UP	KIRC
ENSG00000281404	1.688900e+02	1.127582e+00	2.776777e-01	4.060759e+00	4.890000e-05	2.794440e-04	UP	BLCA
ENSG00000281404	9.379271e+01	1.672061e+00	2.421475e-01	6.905134e+00	5.020000e-12	4.770000e-11	UP	KIRP
ENSG00000281404	7.541610e+01	1.020548e+00	2.243680e-01	4.548546e+00	5.400000e-06	2.040000e-05	UP	UCEC
ENSG00000281404	1.170148e+02	1.594070e+00	1.557488e-01	1.023488e+01	1.380000e-24	1.140000e-23	UP	LUSC
ENSG00000281404	6.535529e+01	1.000142e+00	1.405789e-01	7.114452e+00	1.120000e-12	6.550000e-12	UP	LUAD
ENSG00000281404	5.461077e+01	1.043752e+00	1.960921e-01	5.322764e+00	1.020000e-07	8.220000e-07	UP	STAD
ENSG00000281404	4.658029e+01	1.254043e+00	3.097400e-01	4.048697e+00	5.150000e-05	4.193700e-04	UP	READ

Correlation between lncRNAs and cancer stages.

LncRNA Ensembl ID	Correlation	P-value	Cancer Type	Adjc.p-value
ENSG00000281404	4.337816e-01	2.911729e-03	CHOL	4.143425e-03

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lncRNA-Protein interaction for LINC01176

lncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID

LncRNA ENST ID

LncRNA Name

Protein Ensembl ID

Protein Name

CatRAPID Score

Lncpro Score

UniPortID

Gene Subtype

Public source

lncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID	LncRNA ENST ID	LncRNA Name	Protein Ensembl ID	Protein Name	CatRAPID Score	Lncpro Score	UniPortID	Gene Subtype	Public source
ENSG00000281404	ENST00000628121	LINC01176	ENSG00000130254	SAFB2	44.35	93.7625	Q14151	TF,RBP	NA
ENSG00000281404	ENST00000628121	LINC01176	ENSG00000105127	AKAP8	40.21	92.0799	O43823	TF	NA
ENSG00000281404	ENST00000628121	LINC01176	ENSG00000099326	MZF1	36.83	90.6287	P28698	TF	NA
ENSG00000281404	ENST00000628121	LINC01176	ENSG00000196670	ZFP62	27.66	91.9074	Q8NB50	TF	NA
ENSG00000281404	ENST00000628121	LINC01176	ENSG00000198040	ZNF84	23.76	91.2657	P51523	TF	NA
ENSG00000281404	ENST00000628121	LINC01176	ENSG00000256223	ZNF10	6.73	90.6819	P21506	TF	NA

lncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID	LncRNA ENST ID	LncRNA Name	Protein Ensembl ID	Protein Name	CatRAPID Score	Lncpro Score	UniPortID	Gene Subtype	Public source
ENSG00000281404	ENST00000628121	LINC01176	ENSG00000130254	SAFB2	44.35	93.3677	Q14151	TF,RBP	NA
ENSG00000281404	ENST00000628121	LINC01176	ENSG00000004534	RBM6	43.64	93.5769	P78332	RBP	NA
ENSG00000281404	ENST00000628121	LINC01176	ENSG00000198000	NOL8	39.82	92.9336	Q76FK4	RBP	NA
ENSG00000281404	ENST00000628121	LINC01176	ENSG00000184863	RBM33	12.37	91.8725	Q96EV2	RBP	NA

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lncRNA-DNA interaction for LINC01176

lncRNA targets the enhancer region and positively regulates the gene expression.

lncRNA targets the promoter region and positively regulates the gene expression.

lncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for LINC01176

lncRNA targets the 3'UTR region and negatively regulates the mRNA.

Only predicted by lncTar

CPEB4,SP2,CSTF2,GLYR1,GTF2I,STAU1,SF3A1,HBP1,ZFR,PHAX

Exist in public source

lncRNA targets the skipped exon region.

-lncRNA and exonskipping events are positively correlated.

LncRNA Ensembl ID

LncRNA ENST ID

Exon ID

Skipped Exon

ndG

Gene name with skipped exon

TransID with skipped exon

ORF mutation

-lncRNA and exonskipping events are negatively correlated.

lncRNA and exonskipping events negative correlated

LncRNA Ensembl ID	LncRNA ENST ID	Exon ID	Skipped Exon	dG	ndG	Gene name with skipped exon	TransID with skipped exon	LOF
ENSG00000281404	ENST00000414621	exon_skip_48296	chr10:26755654-26755741	-9.01	-0.1802	ABI1	ENST00000376142	In-frame
ENSG00000281404	ENST00000414621	exon_skip_290158	chr17:42953723-42953778	-6.46	-0.4614	AARSD1	ENST00000427569	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_377198	chr3:123130479-123130616	-11.42	-0.1344	PDIA5	ENST00000316218	Frame-shift
ENSG00000281404	ENST00000628121	exon_skip_389267	chr3:146528613-146528831	-23.73	-0.1130	PLSCR1	ENST00000342435	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_11029	chr1:154989559-154989707	-14.07	-0.1245	FLAD1	ENST00000292180	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_41813	chr10:68337857-68337996	-11.14	-0.1280	HNRNPH3	ENST00000265866	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_95407	chr12:95040475-95040597	-8.53	-0.1028	NR2C1	ENST00000333003	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_309204	chr19:49181348-49181461	-11.98	-0.1141	TRPM4	ENST00000252826	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_374552	chr3:50104247-50104308	-6.97	-0.1515	RBM5	ENST00000347869	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_380242	chr3:186784961-186785101	-11.27	-0.1281	EIF4A2	ENST00000323963	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_382458	chr3:38131595-38131638	-5.95	-0.4577	ACAA1	ENST00000333167	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_436035	chr5:79656957-79657001	-5.42	-0.1322	TENT2	ENST00000296783,ENST00000428308,ENST00000453514	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_442657	chr5:74730259-74730398	-12.90	-0.1016	GFM2	ENST00000296805,ENST00000509430	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_444499	chr5:138164086-138164133	-7.19	-0.2054	BRD8	ENST00000254900	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_53559	chr10:101793912-101793998	-10.00	-0.1695	OGA	ENST00000361464	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_66482	chr11:126274926-126275021	-10.67	-0.1226	FOXRED1	ENST00000263578	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_74009	chr11:64773429-64773505	-11.66	-0.2010	SF1	ENST00000377390	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_87733	chr12:120571190-120571291	-14.48	-0.1463	RNF10	ENST00000325954	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_92074	chr12:50142052-50142110	-4.38	-0.7300	CERS5	ENST00000317551	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_110959	chr14:20372732-20372857	-11.15	-0.1072	TEP1	ENST00000262715	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_111863	chr14:23565815-23565892	-8.80	-0.1143	AP1G2	ENST00000308724,ENST00000397120	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_114365	chr14:74290026-74290118	-14.50	-0.1768	ABCD4	ENST00000356924	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_114376	chr14:74293153-74293248	-16.98	-0.1846	ABCD4	ENST00000356924	Frame-shift
ENSG00000281404	ENST00000628121	exon_skip_127618	chr15:58890280-58890461	-12.93	-0.1002	SLTM	ENST00000380516	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_133217	chr16:8635038-8635079	-7.73	-0.2494	METTL22	ENST00000381920	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_138351	chr16:70469151-70469323	-16.14	-0.1002	FUK	ENST00000288078	Frame-shift
ENSG00000281404	ENST00000628121	exon_skip_300663	chr19:1425877-1425960	-7.59	-0.1186	DAZAP1	ENST00000233078	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_302168	chr19:10680345-10680443	-14.61	-0.1739	ILF3	ENST00000590261	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_313557	chr19:5786748-5786845	-16.06	-0.2200	DUS3L	ENST00000309061	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_319223	chr19:43526200-43526349	-12.89	-0.1302	ETHE1	ENST00000292147	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_327433	chr2:86125794-86125880	-7.73	-0.1380	PTCD3	ENST00000254630	Frame-shift
ENSG00000281404	ENST00000628121	exon_skip_327748	chr2:95410863-95411026	-17.32	-0.1264	FAHD2A	ENST00000233379,ENST00000447036	Frame-shift
ENSG00000281404	ENST00000628121	exon_skip_335558	chr2:240596680-240596942	-23.47	-0.1062	CAPN10	ENST00000391984	Frame-shift
ENSG00000281404	ENST00000628121	exon_skip_338283	chr2:36990647-36990799	-11.99	-0.1110	HEATR5B	ENST00000233099	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_353131	chr20:58669290-58669453	-19.13	-0.1301	STX16	ENST00000371141	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_364260	chr22:29291561-29291599	-5.49	-0.1484	EWSR1	ENST00000397938	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_365497	chr22:38067703-38067770	-7.47	-0.1245	PICK1	ENST00000356976,ENST00000404072	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_370518	chr22:50247691-50247776	-7.98	-0.1078	HDAC10	ENST00000216271	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_370525	chr22:50250426-50250523	-12.98	-0.1564	HDAC10	ENST00000216271	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_374497	chr3:49999439-49999513	-8.05	-0.1184	RBM6	ENST00000266022	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_378467	chr3:143023974-143024018	-9.42	-0.2944	U2SURP	ENST00000473835	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_438188	chr5:141638954-141639021	-9.35	-0.2174	RELL2	ENST00000297164,ENST00000444782	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_445390	chr5:150403120-150403312	-18.14	-0.1417	CD74	ENST00000009530	In-frame
ENSG00000281404	ENST00000414621	exon_skip_466137	chr7:48103296-48103411	-10.39	-0.1998	UPP1	ENST00000331803,ENST00000395564	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_470226	chr7:103307595-103307708	-8.39	-0.1119	PMPCB	ENST00000249269	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_511212	chrX:71555189-71555385	-14.16	-0.1124	OGT	ENST00000373719	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_9446	chr1:147270931-147271005	-7.45	-0.1733	CHD1L	ENST00000369258	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_13857	chr1:168038370-168038488	-10.98	-0.2153	DCAF6	ENST00000312263	Frame-shift
ENSG00000281404	ENST00000414621	exon_skip_514339	chrX:23713134-23713208	-7.40	-0.1138	ACOT9	ENST00000336430	Frame-shift

lncRNA targets by miRNA.

LncRNA Ensembl ID	miRNA ID	LncRNA ENST ID	Binding site in lncRNA	Score	Energy	Align Len	Public source
ENSG00000281404	hsa-mir-152	ENST00000628121	chr7:30391104-30391194	179.00	-87.55	90	NA
ENSG00000281404	hsa-mir-152	ENST00000628121	chr7:30391334-30391426	167.00	-81.02	83	NA
ENSG00000281404	hsa-mir-152	ENST00000414621	chr7:30391019-30391103	159.00	-79.00	80	NA

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Variants for LINC01176

RNA A-to-I editing events in lncRNA.

LncRNAediting ID

LncRNA Ensembl ID

Chromosome

Editing Position

Strand

Gene Type

Gene Name

Transcript ID

Transcript Type

Transcript Name

Edited-associated DElncRNAs in cancer.

LncRNA Ensembl ID

LncRNA Index

Cancer Type

Chr_Postion_Strand

AVE1

AVE2

log2FC

W-value

P-value

Adjc.p-value

Change

Correlation between RNA A-to-I editing events's frequecy and lncRNA expression.

LncRNA Ensembl ID

LncRNA Index

Correlation

P-value

Adjc.p-value

Cis-expression quantitative trait loci(cis-eQTL) of lncRNA.

LncRNA Ensembl ID

LncRNA Name

SNP info

Number of Positive corelated Cancer

Positive corelated Cancer

Number of Negative corelated Cancer

Negative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncRNA regulates differentially expressed genes by function as enhancer.

LncRNA Ensembl ID

PC Gene ID

PC Gene Name

Positive correlated cancers

Cancer with PC gene up-regulation

Cancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

LncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

LncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

LncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID

RBP ID

RBP Gene Name

Exon Skipping ID

Skipped Exon

EX Gene Name

EX Affected TransID

ORF_anno

Cancer Type

LncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID	RBP ID	RBP Gene Name	Exon Skipping ID	Skipped Exon	EX Gene Name	EX Affected TransID	ORF_anno	Cancer Type
ENSG00000281404	ENSG00000004534	RBM6	exon_skip_290158	ENSG00000266967:chr17:42953723-42953778	AARSD1	ENST00000427569	Frame-shift	SKCM,READ,PRAD,PAAD,TGCT
ENSG00000281404	ENSG00000004534	RBM6	exon_skip_382458	ENSG00000060971:chr3:38131595-38131638	ACAA1	ENST00000333167	Frame-shift	STAD,SKCM,READ,PRAD,PAAD,THCA
ENSG00000281404	ENSG00000004534	RBM6	exon_skip_370518	ENSG00000100429:chr22:50247691-50247776	HDAC10	ENST00000216271	Frame-shift	SKCM,READ,PRAD,PAAD,THCA
ENSG00000281404	ENSG00000004534	RBM6	exon_skip_470226	ENSG00000105819:chr7:103307595-103307708	PMPCB	ENST00000249269	Frame-shift	SKCM,LIHC,PAAD,TGCT,THCA

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.

LncRNA Ensembl ID

LncRNA ENST ID

PC Gene Name

PC Gene ID

PC ENST ID

nDG

Cancer with PC gene up-regulation

Cancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncRNA regulates mRNA by competing the miRNA binding site with mRNA.

LncRNA Ensembl ID	lncRNA-miRNA-mRNA	Cancer Types
ENSG00000281404	LINC01176,hsa-mir-152,SH3GLB2	HNSC,THCA,PRAD,UCS,PAAD

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lncRNA coding potential

ORFfinder result for the gencode.v22.lncRNA.transcript.fa.

lncRNA Ensembl ID	lncRNA ENST ID	length(AA)	start at transcript	end at transcript
ENSG00000281404.1	ENST00000628121.1	90	445	173
ENSG00000281404.1	ENST00000414621.1	103	168	479

	lncRNA summary
	lncRNA structure and expression level
	lncRNA-Protein interaction
	lncRNA-DNA interaction
	lncRNA-RNA interaction
	Variants in lncRNA
	lncRNAs regulate the target genes through functioning as enhancers
	lncRNAs regulate the target genes through recruiting transcript factors
	lncRNAs regulate the alternative splicing events through interacting with splicing factor
	lncRNAs regulate mRNA through targeting the 3'-UTR region
	lncRNAs regulate mRNA by competing with miRNA
	lncRNA coding potential