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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000272894

Summary for MIOS-DT

check button Gene summary

Gene informationEnsembl ID

ENSG00000272894

Gene symbol

MIOS-DT

Gene nameMIOS divergent transcript
HGNC

55187

Entrez ID
Gene typelincRNA
SynonymsRP5-1159O4.1|07p21.3|MIOS-DT
UniProtAcc

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Structure and expression level for MIOS-DT

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002728941.042962e+021.067142e+002.945071e-013.623485e+002.906600e-041.324635e-03UPBLCA
ENSG000002728942.413842e+02-1.942848e+004.620388e-01-4.204946e+002.610000e-054.269370e-04DOWNESCA
ENSG000002728943.480177e+021.896232e+001.617995e-011.171964e+011.010000e-311.020000e-29UPPRAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG00000272894-3.109217e-013.020535e-03KICH3.809940e-03
ENSG000002728943.967692e-013.226575e-22PRAD1.584248e-20

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lncRNA-Protein interaction for MIOS-DT

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000272894ENST00000609497RP5-1159O4.1ENSG00000167978SRRM220.0796.3566Q9UQ35RBPNA
ENSG00000272894ENST00000609307RP5-1159O4.1ENSG00000167978SRRM217.6690.4498Q9UQ35RBPNA

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lncRNA-DNA interaction for MIOS-DT

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
PHF1,RBM6,ZBED5,GLI4,RBM39,CENPT,TTC14,HSF4,RBM5,SRRM2,CIRBP,DDX56,ZFP62,ZNF44,MYSM1,SGSM2,AKAP8,ZXDC,ZNF84,RBM4B,DMTF1,TRA2A,MYEF2,ZNF69,DHX34,NR2C1,ZMAT1,ZNF83,THAP9,NSUN6,RNPC3,THOC1,RBM33,DDX17,ZNF10
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
RBM5,E4F1,SRRM2,ZNF69,ZNF83,DDX17,ZMAT1,RBM6,CIRBP,ZFP2,SRSF5
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for MIOS-DT

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for MIOS-DT

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_176593ENSG00000272894.4chr77565947-lincRNARP5-1159O4.1ENST00000609497.4lincRNARP5-1159O4.1-001

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000272894LncEditing_176593UCECchr7_7565947_-3.908913e+001.897360e+009.589805e-017.987942e+001.372102e-153.882424e-15UP
ENSG00000272894LncEditing_176593KIRCchr7_7565947_-2.641021e+001.462968e+001.173437e+006.816626e+009.320324e-121.473404e-11UP
ENSG00000272894LncEditing_176593GBMchr7_7565947_-3.480399e+001.473889e+008.066957e-015.983207e+002.187864e-097.051721e-09UP
ENSG00000272894LncEditing_176593LGGchr7_7565947_-2.926015e+001.593283e+001.140336e+008.702562e+003.244733e-188.677201e-18UP
ENSG00000272894LncEditing_176593KICHchr7_7565947_-2.638660e+001.185047e+008.659046e-014.315351e+001.593493e-057.210258e-05UP
ENSG00000272894LncEditing_176593KIRPchr7_7565947_-2.800475e+002.039298e+002.185322e+004.020909e+005.797389e-057.523202e-05UP
ENSG00000272894LncEditing_176593OVchr7_7565947_-1.819578e+001.126778e+001.446339e+007.380241e+001.580027e-133.818225e-13UP
ENSG00000272894LncEditing_176593LUADchr7_7565947_-3.531484e+002.805650e+003.012597e+004.114501e+003.880176e-054.444752e-05UP
ENSG00000272894LncEditing_176593STADchr7_7565947_-2.600403e+002.456305e+001.215877e+012.562095e+001.040428e-021.072637e-02UP
ENSG00000272894LncEditing_176593PRADchr7_7565947_-5.263183e+003.186730e+001.381485e+008.709352e+003.056156e-181.038039e-17UP
ENSG00000272894LncEditing_176593BRCAchr7_7565947_-2.246399e+001.291309e+001.251910e+001.043692e+011.681823e-252.699084e-25UP
ENSG00000272894LncEditing_176593PAADchr7_7565947_-2.290651e+001.417201e+001.443599e+003.680165e+002.330827e-043.196562e-04UP
ENSG00000272894LncEditing_176593ESCAchr7_7565947_-1.955852e+001.584249e+003.289495e+002.162833e+003.055401e-023.107288e-02UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value
ENSG00000272894LncEditing_176593-3.544702e-018.733333e-041.857974e-03
ENSG00000272894LncEditing_176593-4.389006e-017.409310e-032.177308e-02
ENSG00000272894LncEditing_176593-3.660611e-011.692511e-032.933004e-03
ENSG00000272894LncEditing_176593-7.373308e-013.155519e-043.795357e-03
ENSG00000272894LncEditing_176593-4.491910e-011.007983e-052.769328e-05
ENSG00000272894LncEditing_176593-3.957791e-012.840985e-101.015652e-08
ENSG00000272894LncEditing_176593-3.601566e-014.704437e-037.742254e-03

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000272894.4ENST00000609497.4115248595
ENSG00000272894.4ENST00000609307.11669711471
ENSG00000272894.4ENST00000608807.135141245