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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000270069

Summary for MIR222HG

check button Gene summary

Gene informationEnsembl ID

ENSG00000270069

Gene symbol

MIR222HG

Gene namemiR222/221 cluster host gene
HGNC

49555

Entrez ID
Gene typelincRNA
SynonymsXp11.3|MIR222HG
UniProtAcc

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Structure and expression level for MIR222HG

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002700691.084617e+031.350920e+001.763464e-017.660601e+001.850000e-141.620000e-13UPTHCA
ENSG000002700695.426459e+021.893594e+002.742514e-016.904591e+005.030000e-123.650000e-11UPKICH
ENSG000002700692.237293e+02-1.750962e+003.251451e-01-5.385172e+007.240000e-088.390000e-07DOWNBLCA
ENSG000002700693.921507e+021.094512e+003.223271e-013.395654e+006.846470e-045.867694e-03UPESCA
ENSG000002700691.395776e+021.231833e+002.268730e-015.429612e+005.650000e-082.500000e-07UPCOAD
ENSG000002700692.795342e+021.032723e+002.239202e-014.612016e+003.990000e-062.320000e-05UPSTAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002700693.695170e-013.656049e-04KICH5.591604e-04

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lncRNA-Protein interaction for MIR222HG

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000270069ENST00000602461MIR222HGENSG00000167967E4F179.0892.1345Q66K89TFNA
ENSG00000270069ENST00000602461MIR222HGENSG00000198040ZNF8440.4291.2923P51523TFNA
ENSG00000270069ENST00000602461MIR222HGENSG00000175592FOSL111.290.3358P15407TFChIP-seq

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000270069ENST00000602461MIR222HGENSG00000004534RBM674.9590.0047P78332RBPPredict

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lncRNA-DNA interaction for MIR222HG

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
KLF6,RBM5,KRR1,ZNF83,TRA2A,SKIL,SFPQ,RBM6,RNPC3,CPEB2,FOXP1,THOC1,RBM39,FOSL1,ZNF84,TTC14,CENPT,DDX17,NAF1,CELF1,NR2C1,DMTF1
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
SKIL,RBM5,E4F1,KLF6,RBM39,CELF1,FOXP1,ZNF83,DDX17,RBM6
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for MIR222HG

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000270069ENST00000602507exon_skip_41813chr10:68337857-68337996-15.33-0.1207HNRNPH3ENST00000265866Frame-shift
ENSG00000270069ENST00000602507exon_skip_77641chr11:117207066-117207160-13.91-0.3312PCSK7ENST00000320934Frame-shift
ENSG00000270069ENST00000602507exon_skip_374552chr3:50104247-50104308-9.21-0.1771RBM5ENST00000347869Frame-shift
ENSG00000270069ENST00000602507exon_skip_380242chr3:186784961-186785101-14.74-0.2890EIF4A2ENST00000323963Frame-shift
ENSG00000270069ENST00000602507exon_skip_382458chr3:38131595-38131638-10.73-0.3461ACAA1ENST00000333167Frame-shift
ENSG00000270069ENST00000602507exon_skip_444499chr5:138164086-138164133-6.56-0.1458BRD8ENST00000254900Frame-shift
ENSG00000270069ENST00000602507exon_skip_470226chr7:103307595-103307708-11.71-0.1428PMPCBENST00000249269Frame-shift
ENSG00000270069ENST00000602507exon_skip_133217chr16:8635038-8635079-13.58-0.4850METTL22ENST00000381920Frame-shift

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for MIR222HG

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000270069.1ENST00000602461.1100577275
ENSG00000270069.1ENST00000602507.198635931