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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000268403

Summary for CTD-2371O3.3

check button Gene summary

Gene informationEnsembl ID

ENSG00000268403

Gene symbol

CTD-2371O3.3

Gene name
HGNC
Entrez ID

644656

Gene typeantisense
Synonyms
UniProtAcc

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Structure and expression level for CTD-2371O3.3

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002684037.150649e+011.824521e+003.593618e-015.077114e+003.830000e-072.720000e-06UPCHOL
ENSG000002684037.547275e+011.424462e+001.668586e-018.536942e+001.380000e-172.560000e-16UPPRAD
ENSG000002684036.811903e+011.137257e+009.649880e-021.178519e+014.650000e-325.110000e-31UPBRCA

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002684035.854013e-012.400469e-05CHOL1.160227e-04
ENSG000002684033.154717e-013.380277e-14PRAD2.127841e-13

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lncRNA-Protein interaction for CTD-2371O3.3

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000268403ENST00000596206CTD-2371O3.3ENSG00000204371EHMT284.8291.2065Q96KQ7EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for CTD-2371O3.3

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for CTD-2371O3.3

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
IQGAP1,ACOX1,PDLIM5,A2M,CLTC,TACC1,SEC23A,MYH9
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000268403ENST00000596206exon_skip_430601chr4:82842139-82842481-35.70-0.1182SEC31AENST00000355196,ENST00000395310,ENST00000448323In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000268403ENST00000596206exon_skip_436035chr5:79656957-79657001-10.22-0.2377TENT2ENST00000296783,ENST00000428308,ENST00000453514Frame-shift
ENSG00000268403ENST00000596206exon_skip_41813chr10:68337857-68337996-18.64-0.1792HNRNPH3ENST00000265866Frame-shift
ENSG00000268403ENST00000596206exon_skip_41841chr10:68756272-68756483-27.27-0.1451CCAR1ENST00000265872Frame-shift
ENSG00000268403ENST00000596206exon_skip_53559chr10:101793912-101793998-11.29-0.1737OGAENST00000361464Frame-shift
ENSG00000268403ENST00000596206exon_skip_66482chr11:126274926-126275021-15.11-0.1757FOXRED1ENST00000263578Frame-shift
ENSG00000268403ENST00000596206exon_skip_95407chr12:95040475-95040597-14.07-0.1407NR2C1ENST00000333003Frame-shift
ENSG00000268403ENST00000596206exon_skip_290158chr17:42953723-42953778-8.04-0.1675AARSD1ENST00000427569Frame-shift
ENSG00000268403ENST00000596206exon_skip_319223chr19:43526200-43526349-22.45-0.2118ETHE1ENST00000292147Frame-shift
ENSG00000268403ENST00000596206exon_skip_377198chr3:123130479-123130616-20.13-0.1573PDIA5ENST00000316218Frame-shift
ENSG00000268403ENST00000596206exon_skip_380242chr3:186784961-186785101-14.69-0.1130EIF4A2ENST00000323963Frame-shift
ENSG00000268403ENST00000596206exon_skip_382458chr3:38131595-38131638-10.46-0.3170ACAA1ENST00000333167Frame-shift
ENSG00000268403ENST00000596206exon_skip_470226chr7:103307595-103307708-11.86-0.1318PMPCBENST00000249269Frame-shift
ENSG00000268403ENST00000596206exon_skip_340759chr2:85552415-85552567-14.86-0.1004GGCXENST00000233838Frame-shift

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000268403hsa-mir-22ENST00000596206chr11:9459894-9459986196.00-94.7689NA
ENSG00000268403hsa-mir-22ENST00000596206chr11:9459655-9459744185.00-83.6186NA
ENSG00000268403hsa-mir-22ENST00000596206chr11:9459785-9459859175.00-77.4681NA
ENSG00000268403hsa-mir-22ENST00000596206chr11:9460340-9460438166.00-74.9196NA
ENSG00000268403hsa-mir-22ENST00000596206chr11:9460508-9460595160.00-67.9378NA
ENSG00000268403hsa-mir-22ENST00000596206chr11:9460626-9460701160.00-60.4880NA
ENSG00000268403hsa-mir-22ENST00000596206chr11:9460008-9460095151.00-80.0083NA
ENSG00000268403hsa-mir-22ENST00000596206chr11:9460214-9460293150.00-68.5773NA

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Variants for CTD-2371O3.3

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation
ENSG00000268403ENST00000596206PDLIM5ENSG00000163110ENST00000512274-0.1255149-CHOL
ENSG00000268403ENST00000596206PDLIM5ENSG00000163110ENST00000509357-0.108387-CHOL
ENSG00000268403ENST00000596206PDLIM5ENSG00000163110ENST00000506632-0.12091-CHOL
ENSG00000268403ENST00000596206SEC23AENSG00000100934ENST00000557280-0.3255842-CHOL,PRAD
ENSG00000268403ENST00000596206SEC23AENSG00000100934ENST00000553970-0.3255842-CHOL,PRAD
ENSG00000268403ENST00000596206ACOX1ENSG00000161533ENST00000587927-0.10761-CHOL
ENSG00000268403ENST00000596206ACOX1ENSG00000161533ENST00000589301-0.1054341-CHOL
ENSG00000268403ENST00000596206A2MENSG00000175899ENST00000318602-0.1470324-CHOL,BRCA

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000268403.2ENST00000596206.261574389